ZRT3_YEAST - dbPTM
ZRT3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZRT3_YEAST
UniProt AC P34240
Protein Name Zinc-regulated transporter 3
Gene Name ZRT3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 503
Subcellular Localization Vacuole membrane
Multi-pass membrane protein .
Protein Description Transports zinc from storage in the vacuole to the cytoplasm..
Protein Sequence MEKIPRWLLFSLISSVLCILGALCVPLLSVAFDSKRNSQSKLVNYGLSLSAGSMITTSLYMLLPRIEKSNRFKVFPGLLLGICLSFFLNYLVHAFASESLVHCADSGDHATGSHIHSKSHSHSHSHSHADSHSNFSNDHDLENAPSEHGYATSSSSVSENDPLITKDSDRPQMKKKMSLIDLLTRRKSEGECCDLNKCTPLLQSEQPEYIACVPPVIKSSQSERNVPHGCEGSEDNGQSDDKDHRGLVCVENNIGYDLENLSLYRKNFLSSRHHHSSESPENYGSNQLSHSFSSPLGNDVTENPAALADTQYHPENGSLYPHHHHLETPFSKLLSIGMQTCLVLALHKFPEGFIIFYTNRSDSSKSLGFSIFLSLTIHNFVEGFAMTLPFYTVFESKWVAILITAVLGGGSQPLGALIGYFIFKGSTPRDHEPNMDFLLSVTAGFLLVIGLQMFQTGIGFSDGHHHHQGEGDEEMKQSHSSGTTCLKWCCTGVLLILASALFT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
136PhosphorylationADSHSNFSNDHDLEN
CCCCCCCCCCCCCCC		45.6728889911
153PhosphorylationSEHGYATSSSSVSEN
CCCCCCCCCCCCCCC		21.7628889911
158PhosphorylationATSSSSVSENDPLIT
CCCCCCCCCCCCCCC		32.4127214570
176UbiquitinationDRPQMKKKMSLIDLL
CCHHHHHHHCHHHHH		28.3624961812
178PhosphorylationPQMKKKMSLIDLLTR
HHHHHHHCHHHHHHC		30.9322369663
184PhosphorylationMSLIDLLTRRKSEGE
HCHHHHHHCCCCCCC		35.4122890988
188PhosphorylationDLLTRRKSEGECCDL
HHHHCCCCCCCCCCH		49.3625521595
197UbiquitinationGECCDLNKCTPLLQS
CCCCCHHCCCCCCCC		46.9417644757
218UbiquitinationACVPPVIKSSQSERN
EECCCCCCCCCCCCC		44.2623749301
219PhosphorylationCVPPVIKSSQSERNV
ECCCCCCCCCCCCCC		23.6120377248
220PhosphorylationVPPVIKSSQSERNVP
CCCCCCCCCCCCCCC		32.4920377248
222PhosphorylationPVIKSSQSERNVPHG
CCCCCCCCCCCCCCC		40.2320377248
233PhosphorylationVPHGCEGSEDNGQSD
CCCCCCCCCCCCCCC		21.3420377248
239PhosphorylationGSEDNGQSDDKDHRG
CCCCCCCCCCCCCCC		49.5319823750
256PhosphorylationCVENNIGYDLENLSL
EEECCCCCCHHHHHH		17.3521440633
262PhosphorylationGYDLENLSLYRKNFL
CCCHHHHHHHHHHCH		34.6322369663
264PhosphorylationDLENLSLYRKNFLSS
CHHHHHHHHHHCHHC		19.0321440633
266UbiquitinationENLSLYRKNFLSSRH
HHHHHHHHHCHHCCC		38.1923749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZRT3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZRT3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZRT3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ELO2_YEASTELO2genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RS28A_YEASTRPS28Agenetic
27708008
SWC3_YEASTSWC3genetic
27708008
SAS3_YEASTSAS3genetic
27708008
AVT5_YEASTAVT5genetic
27708008
UBC4_YEASTUBC4genetic
27708008
RXT2_YEASTRXT2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
PHO89_YEASTPHO89genetic
27708008
BUD31_YEASTBUD31genetic
27708008
NHP10_YEASTNHP10genetic
27708008
RPN4_YEASTRPN4genetic
27708008
AIR2_YEASTAIR2genetic
27708008
YDR09_YEASTYDR109Cgenetic
27708008
ARO1_YEASTARO1genetic
27708008
MKC7_YEASTMKC7genetic
27708008
NBP2_YEASTNBP2genetic
27708008
RT103_YEASTRTT103genetic
27708008
SWR1_YEASTSWR1genetic
27708008
YPS7_YEASTYPS7genetic
27708008
VPS72_YEASTVPS72genetic
27708008
CHD1_YEASTCHD1genetic
27708008
IES1_YEASTIES1genetic
27708008
BUD27_YEASTBUD27genetic
27708008
YFF1_YEASTYFL051Cgenetic
27708008
PUF4_YEASTPUF4genetic
27708008
SCY1_YEASTSCY1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
ELP2_YEASTELP2genetic
27708008
TNA1_YEASTTNA1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
LRP1_YEASTLRP1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
DAL81_YEASTDAL81genetic
27708008
GST1_YEASTGTT1genetic
27708008
ISY1_YEASTISY1genetic
27708008
NU133_YEASTNUP133genetic
27708008
SRL3_YEASTSRL3genetic
27708008
ARP6_YEASTARP6genetic
27708008
IOC2_YEASTIOC2genetic
27708008
PFD6_YEASTYKE2genetic
27708008
NKP2_YEASTNKP2genetic
27708008
ELP1_YEASTIKI3genetic
27708008
VPS71_YEASTVPS71genetic
27708008
SUR7_YEASTSUR7genetic
27708008
ELP6_YEASTELP6genetic
27708008
PHO23_YEASTPHO23genetic
27708008
EAF7_YEASTEAF7genetic
27708008
THI20_YEASTTHI20genetic
27708008
GPD2_YEASTGPD2genetic
27708008
VAM3_YEASTVAM3genetic
27708008
SGF11_YEASTSGF11genetic
27708008
ELP3_YEASTELP3genetic
27708008
ELP4_YEASTELP4genetic
27708008
NTO1_YEASTNTO1genetic
27708008
CHMU_YEASTARO7genetic
27708008
MED1_YEASTMED1genetic
27708008
YPR09_YEASTYPR109Wgenetic
27708008
ASNS1_YEASTASN1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZRT3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-153; SER-188AND SER-262, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262, AND MASSSPECTROMETRY.

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