| UniProt ID | THI20_YEAST | |
|---|---|---|
| UniProt AC | Q08224 | |
| Protein Name | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20 | |
| Gene Name | THI20 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 551 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probably that of HMP to HMP-P.. | |
| Protein Sequence | MTYSTVSINTPPPYLTLACNEKLPTVLSIAGTDPSGGAGIEADVKTITAHRCYAMTCITALNAQTPVKVYSINNTPKEVVFQTLESNLKDMKCNVIKTGMLTAAAIEVLHEKLLQLGENRPKLVVDPVLVATSGSSLAGKDIVSLITEKVAPFADILTPNIPECYKLLGEERKVNGLQDIFQIAKDLAKITKCSNILVKGGHIPWNDEKEKYITDVLFLGAEQKFIIFKGNFVNTTHTHGTGCTLASAIASNLARGYSLPQSVYGGIEYVQNAVAIGCDVTKETVKDNGPINHVYAVEIPLEKMLSDECFTASDVIPKKPLKSAADKIPGGNFYEYLINHPKVKPHWDSYINHEFVKKVADGTLERKKFQFFIEQDYAYLVDYARVHCIAGSKAPCLEDMEKELVIVGGVRTEMGQHEKRLKEVFGVKDPDYFQKIKRGPALRAYSRYFNDVSRRGNWQELVASLTPCLMGYGEALTKMKGKVTAPEGSVYHEWCETYASSWYREAMDEGEKLLNHILETYPPEQLDTLVTIYAEVCELETNFWTAALEYE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | Phosphorylation | GIEADVKTITAHRCY CCCCCCEEEECCCEE | 24.33 | 27017623 | |
| 48 | Phosphorylation | EADVKTITAHRCYAM CCCCEEEECCCEEHH | 22.95 | 27017623 | |
| 53 | Phosphorylation | TITAHRCYAMTCITA EEECCCEEHHHHHHH | 10.20 | 27017623 | |
| 56 | Phosphorylation | AHRCYAMTCITALNA CCCEEHHHHHHHHHC | 7.81 | 27017623 | |
| 59 | Phosphorylation | CYAMTCITALNAQTP EEHHHHHHHHHCCCC | 27.52 | 27017623 | |
| 83 | Phosphorylation | PKEVVFQTLESNLKD CHHHHHHHHHHHHHH | 22.49 | 22369663 | |
| 86 | Phosphorylation | VVFQTLESNLKDMKC HHHHHHHHHHHHCCC | 51.04 | 22369663 | |
| 133 | Phosphorylation | DPVLVATSGSSLAGK CCEEEECCCCCCCCH | 27.26 | 27214570 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of THI20_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of THI20_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of THI20_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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