THI21_YEAST - dbPTM
THI21_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THI21_YEAST
UniProt AC Q08975
Protein Name Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21
Gene Name THI21
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 551
Subcellular Localization
Protein Description Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probably that of HMP to HMP-P..
Protein Sequence MTYSTVNINTPPPYLALASNEKLPTVLSIAGTDPSGGAGVEADVKTITAHRCYAMTCITALNAQTPVKVYSINNTPKEVVSQILDANLQDMKCDVIKTGMLTTAAIEVLHEKLLQLGENRPKLVVDPVLVATSGSSLAGKDIASLITEKIAPFADILTPNIPECFKLLGEDREISKLRDIFEVAKDLAKITKCSNILVKGGHIPWNDEEGKYITDVLYLGAEQRFITFKGNFVNTTHTHGTGCTLASAIASNLARGYSLPQSVYGGIEYVQNAVAIGCDVTKETVKDNGPINHVYAIEIPLEKMLSDECFTASDAVHKKPVKSSLNKIPGGSFYKYLINHPKVKPHWDSYVNHDFVRKVADGSLEPKKFQFFIEQDYLYLVNYARISCIAGSKSPCLEDLEKELVIVECVRNGLCQHERRLREEFGIKDPDYLQKIQRGPALRAYCRYFNDVSRRGNWQELVIALNPCLMGYVHALTKIKDEVTAAEGSVYREWCETYSSSWCHEAMLEGEKLLNHILETYPPEKLDTLVTIYAEVCELEANFWTAALEYE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationGVEADVKTITAHRCY
CCCCCCEEEEHHHEE		24.3327017623
48PhosphorylationEADVKTITAHRCYAM
CCCCEEEEHHHEEHH		22.9527017623
53PhosphorylationTITAHRCYAMTCITA
EEEHHHEEHHHHHHH		10.2027017623
56PhosphorylationAHRCYAMTCITALNA
HHHEEHHHHHHHHHC		7.8127017623
59PhosphorylationCYAMTCITALNAQTP
EEHHHHHHHHHCCCC		27.5227017623
102PhosphorylationVIKTGMLTTAAIEVL
EECCCCCHHHHHHHH		12.9020377248
133PhosphorylationDPVLVATSGSSLAGK
CCEEEECCCCCCCCH		27.2627214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THI21_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THI21_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THI21_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
QCR9_YEASTQCR9genetic
21623372
THDH_YEASTILV1genetic
21623372
SPO74_YEASTSPO74genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
MED20_YEASTSRB2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
HEK2_YEASTHEK2genetic
27708008
MBA1_YEASTMBA1genetic
27708008
AIM4_YEASTAIM4genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
SGF73_YEASTSGF73genetic
27708008
MMS2_YEASTMMS2genetic
27708008
SLH1_YEASTSLH1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
SST2_YEASTSST2genetic
27708008
FAR11_YEASTFAR11genetic
27708008
BRE5_YEASTBRE5genetic
27708008
VPH1_YEASTVPH1genetic
27708008
RDL1_YEASTRDL1genetic
27708008
PDE2_YEASTPDE2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THI21_YEAST

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Related Literatures of Post-Translational Modification

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