RDL1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RDL1_YEAST
• UniProt AC: Q12305
• Protein Name: Thiosulfate:glutathione sulfurtransferase {ECO:0000303|PubMed:24981631}
• Gene Name: RDL1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 139
• Subcellular Localization: Mitochondrion .
• Protein Description: Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism. [PubMed: 24981631 Provides the link between the first step in H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate]
• Protein Sequence: MWKAVMNAWNGTESQSKNVSNIQSYSFEDMKRIVGKHDPNVVLVDVREPSEYSIVHIPASINVPYRSHPDAFALDPLEFEKQIGIPKPDSAKELIFYCASGKRGGEAQKVASSHGYSNTSLYPGSMNDWVSHGGDKLDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	NAWNGTESQSKNVSN HHCCCCHHCCCCCCC	39.32	24909858
16	Phosphorylation	WNGTESQSKNVSNIQ CCCCHHCCCCCCCCC	35.16	24909858
20	Phosphorylation	ESQSKNVSNIQSYSF HHCCCCCCCCCEEEH	37.29	19823750
24	Phosphorylation	KNVSNIQSYSFEDMK CCCCCCCEEEHHHHH	20.96	19823750
25	Phosphorylation	NVSNIQSYSFEDMKR CCCCCCEEEHHHHHH	10.87	28889911
26	Phosphorylation	VSNIQSYSFEDMKRI CCCCCEEEHHHHHHH	27.66	19823750
31	Acetylation	SYSFEDMKRIVGKHD EEEHHHHHHHHCCCC	51.82	24489116
31	Succinylation	SYSFEDMKRIVGKHD EEEHHHHHHHHCCCC	51.82	23954790
36	Acetylation	DMKRIVGKHDPNVVL HHHHHHCCCCCCEEE	33.66	22865919
81	Ubiquitination	LDPLEFEKQIGIPKP ECHHHHHHHHCCCCC	53.16	22106047
81	Acetylation	LDPLEFEKQIGIPKP ECHHHHHHHHCCCCC	53.16	24489116
87	Ubiquitination	EKQIGIPKPDSAKEL HHHHCCCCCCCHHHH	60.58	19722269
90	Phosphorylation	IGIPKPDSAKELIFY HCCCCCCCHHHHEEE	50.17	21440633
92	Ubiquitination	IPKPDSAKELIFYCA CCCCCCHHHHEEEEC	57.94	19722269
100	Phosphorylation	ELIFYCASGKRGGEA HHEEEECCCCCCCHH	41.09	21440633
102	Acetylation	IFYCASGKRGGEAQK EEEECCCCCCCHHHH	45.43	24489116
113	Phosphorylation	EAQKVASSHGYSNTS HHHHHHHCCCCCCCC	15.93	21440633
116	Phosphorylation	KVASSHGYSNTSLYP HHHHCCCCCCCCCCC	8.04	19779198
136	Acetylation	WVSHGGDKLDL---- HHHCCCCCCCC----	47.37	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RDL1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RDL1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RDL1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LCF1_YEAST	FAA1	genetic	16269340
PMT3_YEAST	PMT3	genetic	16269340
DGAT2_YEAST	DGA1	genetic	16269340
DYL1_YEAST	DYN2	genetic	16269340
YHK5_YEAST	YHR045W	genetic	16269340
IZH4_YEAST	IZH4	genetic	16269340
PGA3_YEAST	PGA3	genetic	16269340
RGP1_YEAST	RGP1	genetic	16269340
RIC1_YEAST	RIC1	genetic	16269340
RTN1_YEAST	RTN1	physical	11283351
DPM1_YEAST	DPM1	physical	11283351
SKI2_YEAST	SKI2	genetic	19547744
YPC1_YEAST	YPC1	genetic	20093466
RL35A_YEAST	RPL35A	genetic	20093466
RL35B_YEAST	RPL35A	genetic	20093466
MDL1_YEAST	MDL1	genetic	20093466
AEP2_YEAST	AEP2	genetic	20093466
NST1_YEAST	NST1	genetic	20093466
SWS2_YEAST	SWS2	genetic	20093466
ATP23_YEAST	ATP23	genetic	20093466
COQ7_YEAST	CAT5	genetic	20093466
COX10_YEAST	COX10	genetic	20093466
QCR2_YEAST	QCR2	genetic	20093466

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.