LCF1_YEAST - dbPTM
LCF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LCF1_YEAST
UniProt AC P30624
Protein Name Long-chain-fatty-acid--CoA ligase 1
Gene Name FAA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 700
Subcellular Localization
Protein Description Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities..
Protein Sequence MVAQYTVPVGKAANEHETAPRRNYQCREKPLVRPPNTKCSTVYEFVLECFQKNKNSNAMGWRDVKEIHEESKSVMKKVDGKETSVEKKWMYYELSHYHYNSFDQLTDIMHEIGRGLVKIGLKPNDDDKLHLYAATSHKWMKMFLGAQSQGIPVVTAYDTLGEKGLIHSLVQTGSKAIFTDNSLLPSLIKPVQAAQDVKYIIHFDSISSEDRRQSGKIYQSAHDAINRIKEVRPDIKTFSFDDILKLGKESCNEIDVHPPGKDDLCCIMYTSGSTGEPKGVVLKHSNVVAGVGGASLNVLKFVGNTDRVICFLPLAHIFELVFELLSFYWGACIGYATVKTLTSSSVRNCQGDLQEFKPTIMVGVAAVWETVRKGILNQIDNLPFLTKKIFWTAYNTKLNMQRLHIPGGGALGNLVFKKIRTATGGQLRYLLNGGSPISRDAQEFITNLICPMLIGYGLTETCASTTILDPANFELGVAGDLTGCVTVKLVDVEELGYFAKNNQGEVWITGANVTPEYYKNEEETSQALTSDGWFKTGDIGEWEANGHLKIIDRKKNLVKTMNGEYIALEKLESVYRSNEYVANICVYADQSKTKPVGIIVPNHAPLTKLAKKLGIMEQKDSSINIENYLEDAKLIKAVYSDLLKTGKDQGLVGIELLAGIVFFDGEWTPQNGFVTSAQKLKRKDILNAVKDKVDAVYSSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11UbiquitinationQYTVPVGKAANEHET
EEEEECCHHCCCCCC		44.5515699485
38UbiquitinationLVRPPNTKCSTVYEF
CCCCCCCCCCHHHHH		32.5917644757
52UbiquitinationFVLECFQKNKNSNAM
HHHHHHHHCCCCCCC		50.0317644757
54UbiquitinationLECFQKNKNSNAMGW
HHHHHHCCCCCCCCC		69.6417644757
652-HydroxyisobutyrylationAMGWRDVKEIHEESK
CCCCCCHHHHHHHHH		56.06-
71PhosphorylationVKEIHEESKSVMKKV
HHHHHHHHHHHHHHC		27.5228889911
76UbiquitinationEESKSVMKKVDGKET
HHHHHHHHHCCCCCC		47.7117644757
77UbiquitinationESKSVMKKVDGKETS
HHHHHHHHCCCCCCC		27.7117644757
81UbiquitinationVMKKVDGKETSVEKK
HHHHCCCCCCCHHHH		54.0423749301
87UbiquitinationGKETSVEKKWMYYEL
CCCCCHHHHHHHHHH		49.9717644757
88UbiquitinationKETSVEKKWMYYELS
CCCCHHHHHHHHHHH		24.5617644757
118UbiquitinationEIGRGLVKIGLKPND
HHCCCHHEECCCCCC		35.7817644757
122AcetylationGLVKIGLKPNDDDKL
CHHEECCCCCCCCCE		36.2424489116
122UbiquitinationGLVKIGLKPNDDDKL
CHHEECCCCCCCCCE		36.2417644757
128AcetylationLKPNDDDKLHLYAAT
CCCCCCCCEEEEEEE		44.8124489116
128UbiquitinationLKPNDDDKLHLYAAT
CCCCCCCCEEEEEEE		44.8117644757
138UbiquitinationLYAATSHKWMKMFLG
EEEEECCHHHHHHHC		49.0717644757
141UbiquitinationATSHKWMKMFLGAQS
EECCHHHHHHHCHHH		25.9417644757
163UbiquitinationAYDTLGEKGLIHSLV
EECCCCCCCHHHHHH		58.1617644757
163AcetylationAYDTLGEKGLIHSLV
EECCCCCCCHHHHHH		58.1624489116
172PhosphorylationLIHSLVQTGSKAIFT
HHHHHHHCCCCEEEC		35.6222369663
174PhosphorylationHSLVQTGSKAIFTDN
HHHHHCCCCEEECCC		23.4622369663
175UbiquitinationSLVQTGSKAIFTDNS
HHHHCCCCEEECCCC		47.0117644757
189UbiquitinationSLLPSLIKPVQAAQD
CCCHHHHHHCHHHCC		44.4223749301
189AcetylationSLLPSLIKPVQAAQD
CCCHHHHHHCHHHCC		44.4224489116
198UbiquitinationVQAAQDVKYIIHFDS
CHHHCCCEEEEEECC		38.7317644757
207PhosphorylationIIHFDSISSEDRRQS
EEEECCCCHHHHHHH		31.4624961812
208PhosphorylationIHFDSISSEDRRQSG
EEECCCCHHHHHHHC		41.6724961812
214PhosphorylationSSEDRRQSGKIYQSA
CHHHHHHHCCCHHHH		40.0024961812
216UbiquitinationEDRRQSGKIYQSAHD
HHHHHHCCCHHHHHH		43.4117644757
229UbiquitinationHDAINRIKEVRPDIK
HHHHHHHHHHCCCCC		47.0917644757
236AcetylationKEVRPDIKTFSFDDI
HHHCCCCCEECHHHH		51.3924489116
236UbiquitinationKEVRPDIKTFSFDDI
HHHCCCCCEECHHHH		51.3924961812
239PhosphorylationRPDIKTFSFDDILKL
CCCCCEECHHHHHHH		32.7521440633
245AcetylationFSFDDILKLGKESCN
ECHHHHHHHCHHCCC		56.3724489116
245UbiquitinationFSFDDILKLGKESCN
ECHHHHHHHCHHCCC		56.3724961812
261UbiquitinationIDVHPPGKDDLCCIM
CCCCCCCCCCEEEEE		54.5723749301
283UbiquitinationEPKGVVLKHSNVVAG
CCEEEEEEECCEEEE		33.1217644757
300UbiquitinationGASLNVLKFVGNTDR
CCCEEHHHHCCCCCC		33.4517644757
373UbiquitinationAVWETVRKGILNQID
HHHHHHHHHHHHHHC		46.0617644757
387AcetylationDNLPFLTKKIFWTAY
CCCCCHHHHHHHHHC		46.1224489116
387UbiquitinationDNLPFLTKKIFWTAY
CCCCCHHHHHHHHHC		46.1217644757
388UbiquitinationNLPFLTKKIFWTAYN
CCCCHHHHHHHHHCC		37.5917644757
397AcetylationFWTAYNTKLNMQRLH
HHHHCCCCCCEEEEE		33.9424489116
417AcetylationALGNLVFKKIRTATG
HHHHHHEEEEECCCC		39.5524489116
429PhosphorylationATGGQLRYLLNGGSP
CCCCCHHHHHCCCCC		24.9228889911
435PhosphorylationRYLLNGGSPISRDAQ
HHHHCCCCCCCHHHH		22.0622369663
438PhosphorylationLNGGSPISRDAQEFI
HCCCCCCCHHHHHHH		27.7322369663
488UbiquitinationLTGCVTVKLVDVEEL
CCCCEEEEEECHHHH		33.1717644757
500UbiquitinationEELGYFAKNNQGEVW
HHHCEEEECCCCCEE		46.6722817900
524PhosphorylationYYKNEEETSQALTSD
HHCCHHHHHHCCCCC		29.4427017623
535UbiquitinationLTSDGWFKTGDIGEW
CCCCCCEECCCCCEE		45.1217644757
549AcetylationWEANGHLKIIDRKKN
EEECCEEEEEECCCC		31.7624489116
549UbiquitinationWEANGHLKIIDRKKN
EEECCEEEEEECCCC		31.7617644757
559AcetylationDRKKNLVKTMNGEYI
ECCCCEEEECCCCEE		45.2624489116
559UbiquitinationDRKKNLVKTMNGEYI
ECCCCEEEECCCCEE		45.2617644757
570AcetylationGEYIALEKLESVYRS
CCEEEHHHHHHHHHC		59.4124489116
570UbiquitinationGEYIALEKLESVYRS
CCEEEHHHHHHHHHC		59.4117644757
592UbiquitinationCVYADQSKTKPVGII
EEEECCCCCCCEEEE		55.7417644757
594UbiquitinationYADQSKTKPVGIIVP
EECCCCCCCEEEECC		41.2517644757
608UbiquitinationPNHAPLTKLAKKLGI
CCCCHHHHHHHHHCC		54.8817644757
608AcetylationPNHAPLTKLAKKLGI
CCCCHHHHHHHHHCC		54.8824489116
611UbiquitinationAPLTKLAKKLGIMEQ
CHHHHHHHHHCCCCC		59.9917644757
612UbiquitinationPLTKLAKKLGIMEQK
HHHHHHHHHCCCCCC		46.4617644757
612AcetylationPLTKLAKKLGIMEQK
HHHHHHHHHCCCCCC		46.4624489116
619UbiquitinationKLGIMEQKDSSINIE
HHCCCCCCCCCCCHH		46.3923749301
619AcetylationKLGIMEQKDSSINIE
HHCCCCCCCCCCCHH		46.3924489116
621PhosphorylationGIMEQKDSSINIENY
CCCCCCCCCCCHHHH		39.9022369663
622PhosphorylationIMEQKDSSINIENYL
CCCCCCCCCCHHHHH		29.7722369663
633UbiquitinationENYLEDAKLIKAVYS
HHHHHHHHHHHHHHH		64.1717644757
633AcetylationENYLEDAKLIKAVYS
HHHHHHHHHHHHHHH		64.1724489116
636UbiquitinationLEDAKLIKAVYSDLL
HHHHHHHHHHHHHHH		42.0815699485
636AcetylationLEDAKLIKAVYSDLL
HHHHHHHHHHHHHHH		42.0824489116
639PhosphorylationAKLIKAVYSDLLKTG
HHHHHHHHHHHHHHC		11.0028889911
640PhosphorylationKLIKAVYSDLLKTGK
HHHHHHHHHHHHHCC		18.3828889911
644UbiquitinationAVYSDLLKTGKDQGL
HHHHHHHHHCCCCCC		63.6315699485
644AcetylationAVYSDLLKTGKDQGL
HHHHHHHHHCCCCCC		63.6324489116
645PhosphorylationVYSDLLKTGKDQGLV
HHHHHHHHCCCCCCE		49.8128889911
681UbiquitinationVTSAQKLKRKDILNA
CCCHHHHCHHHHHHH		65.5217644757
683UbiquitinationSAQKLKRKDILNAVK
CHHHHCHHHHHHHHH		47.7517644757
690SuccinylationKDILNAVKDKVDAVY
HHHHHHHHHHHHHHH		49.8023954790
690UbiquitinationKDILNAVKDKVDAVY
HHHHHHHHHHHHHHH		49.8017644757
692UbiquitinationILNAVKDKVDAVYSS
HHHHHHHHHHHHHCC		35.9817644757
698PhosphorylationDKVDAVYSSS-----
HHHHHHHCCC-----		19.9428889911
699PhosphorylationKVDAVYSSS------
HHHHHHCCC------		23.5222369663
700PhosphorylationVDAVYSSS-------
HHHHHCCC-------		38.0022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LCF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LCF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LCF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FAT1_YEASTFAT1physical
12601005
FAT1_YEASTFAT1genetic
12601005
LCF4_YEASTFAA4genetic
12601005
LCF4_YEASTFAA4genetic
11477098
LCF4_YEASTFAA4genetic
9988704
LCF4_YEASTFAA4genetic
7738025
NM111_YEASTNMA111physical
16470384
SNC1_YEASTSNC1genetic
16233202
BFR1_YEASTBFR1genetic
16269340
MPD1_YEASTMPD1genetic
16269340
RDL1_YEASTRDL1genetic
16269340
HUA2_YEASTHUA2genetic
16269340
PLMT_YEASTOPI3genetic
16269340
RBD2_YEASTRBD2genetic
16269340
MGA2_YEASTMGA2genetic
16269340
SCS7_YEASTSCS7genetic
16269340
LCF4_YEASTFAA4genetic
18408719
ACO1_YEASTOLE1genetic
20516150
SRS2_YEASTSRS2genetic
21459050
DCOR_YEASTSPE1genetic
21623372
FABG_YEASTOAR1genetic
21623372
QCR7_YEASTQCR7genetic
21623372
PDX3_YEASTPDX3genetic
21623372
CSG2_YEASTCSG2genetic
21623372
CSG2_YEASTCSG2genetic
21987634
UGO1_YEASTUGO1genetic
21987634
ISC1_YEASTISC1genetic
21987634
THDH_YEASTILV1genetic
21987634
HUA2_YEASTHUA2genetic
21987634
RDL1_YEASTRDL1genetic
21987634
UBX1_YEASTSHP1genetic
23891562
ELO3_YEASTELO3genetic
23891562
CSG2_YEASTCSG2genetic
23891562
MCFS2_YEASTEHT1genetic
24370880
LCF4_YEASTFAA4genetic
24752690
ACOX_YEASTPOX1genetic
24752690
LCF4_YEASTFAA4genetic
24769906
ACOT5_MOUSEAcot5genetic
24769906
CSG2_YEASTCSG2genetic
27708008
GPR1_YEASTGPR1genetic
27708008
ILM1_YEASTILM1genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
BUL2_YEASTBUL2genetic
27708008
PMP1_YEASTPMP1physical
26404137
PRY1_YEASTPRY1genetic
28365570
PRY2_YEASTPRY2genetic
28365570
PRY3_YEASTPRY3genetic
28365570
CDC42_YEASTCDC42genetic
27453043
SERB_YEASTSER2genetic
27453043
TOP1_YEASTTOP1genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LCF1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-622, AND MASSSPECTROMETRY.

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