ACOT5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACOT5_MOUSE
• UniProt AC: Q6Q2Z6
• Protein Name: Acyl-coenzyme A thioesterase 5
• Gene Name: Acot5
• Organism: Mus musculus (Mouse).
• Sequence Length: 421
• Subcellular Localization: Peroxisome.
• Protein Description: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Seems to be involved in intraperoxisomal regulation of acyl-CoA levels, but not CoASH levels. Mainly active on medium-chain acyl-CoAs. May have a function in termination of beta-oxidation of fatty acids..
• Protein Sequence: MVPTVSLEPTGHSCWDEPLSIAVRGLAPEQPVTLRTALRDEKGALFRAHARYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQTPFVVELEVLDGHEPDGGRLLARAVHERHFMAPGVRRVPVREGRVRATLFLPPGTGPFPGIIDLFGVGGGLLEYRASLLAGKGFAVMALAYYKYDDLPKVIDILHLEYFEEAVTYLLSHPQVKGPGVGLLGISKGAELSLSMASFLKGITAAVVINGATVNVISTLYYKEESLPGLGMHLERIKVTKDGFKDIIDILNVPLEAPDQKSLIPLERSDTAFLFLVGQDDHNWKSEFYAREASKRLQAHGKEKPQIVCYPKTGHHIEPPYIPWSIAAPHSYFDKPILLGGEPRAHAMAQVDAWQRLQTFFHKHLSGDKRPSPAKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	SLEPTGHSCWDEPLS CEECCCCCCCCCCCE	20.46	26525534
42	Acetylation	RTALRDEKGALFRAH HHHHCCCCCCEEEEE	54.49	23576753
42	Ubiquitination	RTALRDEKGALFRAH HHHHCCCCCCEEEEE	54.49	-
52	Phosphorylation	LFRAHARYRADSHGE EEEEEEECCCCCCCC	15.78	26239621
56	Phosphorylation	HARYRADSHGELDLA EEECCCCCCCCCCEE	32.19	25521595
249	Phosphorylation	ASFLKGITAAVVING HHHHCCCCEEEEECC	19.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACOT5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACOT5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACOT5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACOT5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS.";
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
Mol. Cell. Proteomics 6:669-676(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, AND MASSSPECTROMETRY.
PubMed: 17208939