| UniProt ID | ACO1_YEAST | |
|---|---|---|
| UniProt AC | P21147 | |
| Protein Name | Acyl-CoA desaturase 1 | |
| Gene Name | OLE1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 510 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. [PubMed: 1978720] | |
| Protein Sequence | MPTSGTTIELIDDQFPKDDSASSGIVDEVDLTEANILATGLNKKAPRIVNGFGSLMGSKEMVSVEFDKKGNEKKSNLDRLLEKDNQEKEEAKTKIHISEQPWTLNNWHQHLNWLNMVLVCGMPMIGWYFALSGKVPLHLNVFLFSVFYYAVGGVSITAGYHRLWSHRSYSAHWPLRLFYAIFGCASVEGSAKWWGHSHRIHHRYTDTLRDPYDARRGLWYSHMGWMLLKPNPKYKARADITDMTDDWTIRFQHRHYILLMLLTAFVIPTLICGYFFNDYMGGLIYAGFIRVFVIQQATFCINSLAHYIGTQPFDDRRTPRDNWITAIVTFGEGYHNFHHEFPTDYRNAIKWYQYDPTKVIIYLTSLVGLAYDLKKFSQNAIEEALIQQEQKKINKKKAKINWGPVLTDLPMWDKQTFLAKSKENKGLVIISGIVHDVSGYISEHPGGETLIKTALGKDATKAFSGGVYRHSNAAQNVLADMRVAVIKESKNSAIRMASKRGEIYETGKFF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MPTSGTTIEL -----CCCCCCEEEE | 38.19 | 27214570 | |
| 4 | Phosphorylation | ----MPTSGTTIELI ----CCCCCCEEEEC | 28.42 | 27214570 | |
| 6 | Phosphorylation | --MPTSGTTIELIDD --CCCCCCEEEECCC | 25.11 | 19823750 | |
| 7 | Phosphorylation | -MPTSGTTIELIDDQ -CCCCCCEEEECCCC | 18.91 | 19823750 | |
| 23 | Phosphorylation | PKDDSASSGIVDEVD CCCCCCCCCCCCEEE | 32.05 | 21551504 | |
| 54 | Phosphorylation | RIVNGFGSLMGSKEM CHHCCCHHHCCCCCE | 16.96 | 22369663 | |
| 58 | Phosphorylation | GFGSLMGSKEMVSVE CCHHHCCCCCEEEEE | 16.10 | 22369663 | |
| 59 | Ubiquitination | FGSLMGSKEMVSVEF CHHHCCCCCEEEEEE | 44.06 | 17644757 | |
| 63 | Phosphorylation | MGSKEMVSVEFDKKG CCCCCEEEEEECCCC | 18.02 | 28889911 | |
| 68 | Acetylation | MVSVEFDKKGNEKKS EEEEEECCCCCCCCC | 68.82 | 24489116 | |
| 75 | Phosphorylation | KKGNEKKSNLDRLLE CCCCCCCCHHHHHHH | 54.41 | 30377154 | |
| 83 | Acetylation | NLDRLLEKDNQEKEE HHHHHHHHHHHHHHH | 63.05 | 24489116 | |
| 88 | Acetylation | LEKDNQEKEEAKTKI HHHHHHHHHHHHHEE | 51.60 | 24489116 | |
| 350 | Acetylation | TDYRNAIKWYQYDPT CCHHHHHHHHCCCCC | 37.12 | 24489116 | |
| 350 | Ubiquitination | TDYRNAIKWYQYDPT CCHHHHHHHHCCCCC | 37.12 | 23749301 | |
| 374 | Ubiquitination | VGLAYDLKKFSQNAI HHHHHHHHHHHHHHH | 49.20 | 17644757 | |
| 375 | Ubiquitination | GLAYDLKKFSQNAIE HHHHHHHHHHHHHHH | 58.51 | 23749301 | |
| 391 | Acetylation | ALIQQEQKKINKKKA HHHHHHHHHHHHHHC | 55.67 | 24489116 | |
| 391 | Ubiquitination | ALIQQEQKKINKKKA HHHHHHHHHHHHHHC | 55.67 | 23749301 | |
| 392 | Ubiquitination | LIQQEQKKINKKKAK HHHHHHHHHHHHHCC | 51.73 | 22817900 | |
| 395 | Ubiquitination | QEQKKINKKKAKINW HHHHHHHHHHCCCCC | 60.15 | 22817900 | |
| 396 | Ubiquitination | EQKKINKKKAKINWG HHHHHHHHHCCCCCC | 54.17 | 22817900 | |
| 399 | Ubiquitination | KINKKKAKINWGPVL HHHHHHCCCCCCCCC | 45.51 | 17644757 | |
| 414 | Ubiquitination | TDLPMWDKQTFLAKS CCCCCCCCCCHHHHC | 35.41 | 17644757 | |
| 425 | Ubiquitination | LAKSKENKGLVIISG HHHCCCCCCEEEEEE | 55.50 | 17644757 | |
| 452 | Ubiquitination | PGGETLIKTALGKDA CCCCEEHHHHCCCCC | 30.75 | 17644757 | |
| 457 | Ubiquitination | LIKTALGKDATKAFS EHHHHCCCCCHHHHC | 45.07 | 23749301 | |
| 461 | Acetylation | ALGKDATKAFSGGVY HCCCCCHHHHCCCCC | 49.51 | 24489116 | |
| 461 | Ubiquitination | ALGKDATKAFSGGVY HCCCCCHHHHCCCCC | 49.51 | 23749301 | |
| 487 | Ubiquitination | DMRVAVIKESKNSAI HCEEEHHHCCHHHHH | 49.70 | 23749301 | |
| 490 | Ubiquitination | VAVIKESKNSAIRMA EEHHHCCHHHHHHHH | 56.89 | 22817900 | |
| 492 | Phosphorylation | VIKESKNSAIRMASK HHHCCHHHHHHHHHH | 28.89 | 27717283 | |
| 498 | Phosphorylation | NSAIRMASKRGEIYE HHHHHHHHHCCCHHC | 17.34 | 27717283 | |
| 499 | Ubiquitination | SAIRMASKRGEIYET HHHHHHHHCCCHHCC | 55.68 | 17644757 | |
| 504 | Phosphorylation | ASKRGEIYETGKFF- HHHCCCHHCCCCCC- | 11.79 | 27017623 | |
| 508 | Ubiquitination | GEIYETGKFF----- CCHHCCCCCC----- | 51.52 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACO1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACO1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACO1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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