| UniProt ID | HEM6_YEAST | |
|---|---|---|
| UniProt AC | P11353 | |
| Protein Name | Oxygen-dependent coproporphyrinogen-III oxidase | |
| Gene Name | HEM13 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 328 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).. | |
| Protein Sequence | MPAPQDPRNLPIRQQMEALIRRKQAEITQGLESIDTVKFHADTWTRGNDGGGGTSMVIQDGTTFEKGGVNVSVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAPTTHLNYRYFETWNQDGTPQTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKKWCDEYFYITHRKETRGIGGIFFDDYDERDPQEILKMVEDCFDAFLPSYLTIVKRRKDMPYTKEEQQWQAIRRGRYVEFNLIYDRGTQFGLRTPGSRVESILMSLPEHASWLYNHHPAPGSREAKLLEVTTKPREWVK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 72 | Phosphorylation | EKGGVNVSVVYGQLS EECCEEEEEEEECCC | 10.72 | 22369663 | |
| 75 | Phosphorylation | GVNVSVVYGQLSPAA CEEEEEEEECCCHHH | 9.30 | 22369663 | |
| 79 | Phosphorylation | SVVYGQLSPAAVSAM EEEEECCCHHHHHHH | 12.47 | 22369663 | |
| 84 | Phosphorylation | QLSPAAVSAMKADHK CCCHHHHHHHHHCCC | 20.23 | 22369663 | |
| 100 | Ubiquitination | LRLPEDPKTGLPVTD CCCCCCCCCCCCCCC | 68.49 | 23749301 | |
| 100 | Acetylation | LRLPEDPKTGLPVTD CCCCCCCCCCCCCCC | 68.49 | 24489116 | |
| 180 | Acetylation | LHKDALDKHDTALYP HHHHHHHHCCCCHHH | 44.20 | 24489116 | |
| 253 | Acetylation | RKDMPYTKEEQQWQA CCCCCCCHHHHHHHH | 54.10 | 24489116 | |
| 277 | Phosphorylation | NLIYDRGTQFGLRTP EEEEECCCCCCCCCC | 22.94 | 28889911 | |
| 283 | Phosphorylation | GTQFGLRTPGSRVES CCCCCCCCCCCCHHH | 36.72 | 28889911 | |
| 286 | Phosphorylation | FGLRTPGSRVESILM CCCCCCCCCHHHHHH | 34.06 | 28889911 | |
| 315 | Acetylation | APGSREAKLLEVTTK CCCCCCEEEEEEECC | 49.18 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HEM6_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HEM6_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HEM6_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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