PAL1_YEAST - dbPTM
PAL1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PAL1_YEAST
UniProt AC Q05518
Protein Name Protein PAL1
Gene Name PAL1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 499
Subcellular Localization Cell membrane
Peripheral membrane protein . Localizes to the cell periphery and the bud neck. Found at endocytic sites at the cell periphery during the early stages of endocytosis.
Protein Description Involved in the early step of endocytosis..
Protein Sequence MENRNSSTSSRPFSVNNPFRNATVDSSINQYKNDSQFQEWAKNQSRTNSFDMPQLNTRTSSQLSFPNIPEDEPQRNADQQGAFYSGLESFSSGSLSPPSRPLSSKNPFLDDVSSATDFRRSPPPVSRNKNHPTAKEEKEQLRQRYLEESDVSTVGNTRENTDLPPSYEEITSTNGSRRAYPKEKVSRPSSHREHSNSGTYISRRSSSHHHREASSSSTPSKKGKRKSKVIVPKNVDTIDKLDVTGLFGGSFHHDGPFDAVTPHRNKNNKAAPVLAFPVDGPNSTIGGASTKKSALDEVFGRDDTDDSDIYQYSSQTLRRGGDTQDAIKANVGNVQQMDAKNKTELVHGPVTAGLGSSTFLDGAPASSAAIRNDIKAHSYHNRNGGLQRNKSLSQRLGLGGSGDSNAPMTGVRRNLSLSRDNYDVGHSNEGVRRSKTVNSPNRTHKSNYTTDFDGQDDHNEDEEDVYLGVRYNEPNMKKKSTGSKLLSRVKSLKVGRKSQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MENRNSSTSSRPF
--CCCCCCCCCCCCC		31.5822369663
7Phosphorylation-MENRNSSTSSRPFS
-CCCCCCCCCCCCCC		35.5422369663
8PhosphorylationMENRNSSTSSRPFSV
CCCCCCCCCCCCCCC		30.4622369663
9PhosphorylationENRNSSTSSRPFSVN
CCCCCCCCCCCCCCC		26.7122369663
10PhosphorylationNRNSSTSSRPFSVNN
CCCCCCCCCCCCCCC		44.0222369663
14PhosphorylationSTSSRPFSVNNPFRN
CCCCCCCCCCCCCCC		26.9822369663
23PhosphorylationNNPFRNATVDSSINQ
CCCCCCCCCCCHHHH		28.5322369663
26PhosphorylationFRNATVDSSINQYKN
CCCCCCCCHHHHHCC		28.8722369663
27PhosphorylationRNATVDSSINQYKND
CCCCCCCHHHHHCCH		22.5422369663
31PhosphorylationVDSSINQYKNDSQFQ
CCCHHHHHCCHHHHH		13.7922369663
32UbiquitinationDSSINQYKNDSQFQE
CCHHHHHCCHHHHHH		44.5123749301
35PhosphorylationINQYKNDSQFQEWAK
HHHHCCHHHHHHHHH		42.1422369663
42UbiquitinationSQFQEWAKNQSRTNS
HHHHHHHHCCCCCCC		57.5023749301
45PhosphorylationQEWAKNQSRTNSFDM
HHHHHCCCCCCCCCC		50.9322369663
47PhosphorylationWAKNQSRTNSFDMPQ
HHHCCCCCCCCCCCC		40.2222369663
49PhosphorylationKNQSRTNSFDMPQLN
HCCCCCCCCCCCCCC		23.2422369663
57PhosphorylationFDMPQLNTRTSSQLS
CCCCCCCCCCCCCCC		43.8722890988
59PhosphorylationMPQLNTRTSSQLSFP
CCCCCCCCCCCCCCC		30.5922369663
60PhosphorylationPQLNTRTSSQLSFPN
CCCCCCCCCCCCCCC		16.8822369663
61PhosphorylationQLNTRTSSQLSFPNI
CCCCCCCCCCCCCCC		34.2322369663
64PhosphorylationTRTSSQLSFPNIPED
CCCCCCCCCCCCCCC		30.9022369663
84PhosphorylationADQQGAFYSGLESFS
HHHCCCCHHCHHCCC		10.9922369663
85PhosphorylationDQQGAFYSGLESFSS
HHCCCCHHCHHCCCC		30.3722369663
89PhosphorylationAFYSGLESFSSGSLS
CCHHCHHCCCCCCCC		35.1622369663
91PhosphorylationYSGLESFSSGSLSPP
HHCHHCCCCCCCCCC		42.9722369663
92PhosphorylationSGLESFSSGSLSPPS
HCHHCCCCCCCCCCC		30.3222369663
94PhosphorylationLESFSSGSLSPPSRP
HHCCCCCCCCCCCCC		27.8522369663
96PhosphorylationSFSSGSLSPPSRPLS
CCCCCCCCCCCCCCC		36.1422369663
99PhosphorylationSGSLSPPSRPLSSKN
CCCCCCCCCCCCCCC		50.3323749301
103PhosphorylationSPPSRPLSSKNPFLD
CCCCCCCCCCCCCCC		41.7822369663
104PhosphorylationPPSRPLSSKNPFLDD
CCCCCCCCCCCCCCC		44.1023749301
105UbiquitinationPSRPLSSKNPFLDDV
CCCCCCCCCCCCCCC		66.3217644757
113PhosphorylationNPFLDDVSSATDFRR
CCCCCCCCCCCCHHH		22.6522369663
114PhosphorylationPFLDDVSSATDFRRS
CCCCCCCCCCCHHHC		34.7322369663
116PhosphorylationLDDVSSATDFRRSPP
CCCCCCCCCHHHCCC		37.3022369663
121PhosphorylationSATDFRRSPPPVSRN
CCCCHHHCCCCCCCC		37.1922369663
126PhosphorylationRRSPPPVSRNKNHPT
HHCCCCCCCCCCCCC		35.5920377248
135UbiquitinationNKNHPTAKEEKEQLR
CCCCCCHHHHHHHHH		69.7322817900
138UbiquitinationHPTAKEEKEQLRQRY
CCCHHHHHHHHHHHH		52.4223793018
145PhosphorylationKEQLRQRYLEESDVS
HHHHHHHHHHHCCCC		15.3222890988
149PhosphorylationRQRYLEESDVSTVGN
HHHHHHHCCCCCCCC		33.6622369663
152PhosphorylationYLEESDVSTVGNTRE
HHHHCCCCCCCCCCC		23.5122890988
153PhosphorylationLEESDVSTVGNTREN
HHHCCCCCCCCCCCC		32.0822369663
161PhosphorylationVGNTRENTDLPPSYE
CCCCCCCCCCCCCHH		33.8723749301
167PhosphorylationNTDLPPSYEEITSTN
CCCCCCCHHHHHCCC		24.2927214570
172PhosphorylationPSYEEITSTNGSRRA
CCHHHHHCCCCCCCC		26.0723749301
173PhosphorylationSYEEITSTNGSRRAY
CHHHHHCCCCCCCCC		34.6423749301
176PhosphorylationEITSTNGSRRAYPKE
HHHCCCCCCCCCCCH		22.2123749301
182UbiquitinationGSRRAYPKEKVSRPS
CCCCCCCCHHCCCCC		58.4522817900
184UbiquitinationRRAYPKEKVSRPSSH
CCCCCCHHCCCCCCC		52.1923749301
195PhosphorylationPSSHREHSNSGTYIS
CCCCCCCCCCCCEEE		28.1222369663
197PhosphorylationSHREHSNSGTYISRR
CCCCCCCCCCEEECC		35.2122369663
199PhosphorylationREHSNSGTYISRRSS
CCCCCCCCEEECCCC		19.9422890988
200PhosphorylationEHSNSGTYISRRSSS
CCCCCCCEEECCCCC		10.6322890988
202PhosphorylationSNSGTYISRRSSSHH
CCCCCEEECCCCCCC		15.9522890988
214PhosphorylationSHHHREASSSSTPSK
CCCCCCCCCCCCCCC		26.4628889911
215PhosphorylationHHHREASSSSTPSKK
CCCCCCCCCCCCCCC		35.0428889911
216PhosphorylationHHREASSSSTPSKKG
CCCCCCCCCCCCCCC		35.4228889911
217PhosphorylationHREASSSSTPSKKGK
CCCCCCCCCCCCCCC		46.4125315811
218PhosphorylationREASSSSTPSKKGKR
CCCCCCCCCCCCCCC		33.2628889911
220PhosphorylationASSSSTPSKKGKRKS
CCCCCCCCCCCCCCC		47.2728889911
227PhosphorylationSKKGKRKSKVIVPKN
CCCCCCCCCEEECCC		35.8723749301
233AcetylationKSKVIVPKNVDTIDK
CCCEEECCCCCCCCC		59.7224489116
233UbiquitinationKSKVIVPKNVDTIDK
CCCEEECCCCCCCCC		59.7217644757
240UbiquitinationKNVDTIDKLDVTGLF
CCCCCCCCCCCCEEC		42.6117644757
269UbiquitinationPHRNKNNKAAPVLAF
CCCCCCCCCCCEEEE		56.1523749301
283PhosphorylationFPVDGPNSTIGGAST
EECCCCCCCCCCCCC		25.2421440633
289PhosphorylationNSTIGGASTKKSALD
CCCCCCCCCCHHHHH		43.9921440633
291UbiquitinationTIGGASTKKSALDEV
CCCCCCCCHHHHHHH		42.0822106047
292UbiquitinationIGGASTKKSALDEVF
CCCCCCCHHHHHHHH		40.8422106047
293PhosphorylationGGASTKKSALDEVFG
CCCCCCHHHHHHHHC		35.3022369663
304PhosphorylationEVFGRDDTDDSDIYQ
HHHCCCCCCCCCHHH		46.0922369663
307PhosphorylationGRDDTDDSDIYQYSS
CCCCCCCCCHHHHHH		28.8122369663
310PhosphorylationDTDDSDIYQYSSQTL
CCCCCCHHHHHHHHH		13.3419779198
312PhosphorylationDDSDIYQYSSQTLRR
CCCCHHHHHHHHHHC		8.0421440633
313PhosphorylationDSDIYQYSSQTLRRG
CCCHHHHHHHHHHCC		10.6328889911
314PhosphorylationSDIYQYSSQTLRRGG
CCHHHHHHHHHHCCC		23.4220377248
316PhosphorylationIYQYSSQTLRRGGDT
HHHHHHHHHHCCCCH		24.9521551504
323PhosphorylationTLRRGGDTQDAIKAN
HHHCCCCHHHHHHHH		31.4620377248
328UbiquitinationGDTQDAIKANVGNVQ
CCHHHHHHHHCCCHH		35.3123749301
340UbiquitinationNVQQMDAKNKTELVH
CHHHCCCCCCCEEEE		55.5023749301
342UbiquitinationQQMDAKNKTELVHGP
HHCCCCCCCEEEECC		42.5423749301
343PhosphorylationQMDAKNKTELVHGPV
HCCCCCCCEEEECCC		43.9027017623
351PhosphorylationELVHGPVTAGLGSST
EEEECCCCCCCCCCC		20.3827017623
356PhosphorylationPVTAGLGSSTFLDGA
CCCCCCCCCCCCCCC		31.1121440633
357PhosphorylationVTAGLGSSTFLDGAP
CCCCCCCCCCCCCCC		22.7521440633
375UbiquitinationAAIRNDIKAHSYHNR
HHHHHHHHHHCCCCC		42.8023749301
378PhosphorylationRNDIKAHSYHNRNGG
HHHHHHHCCCCCCCC		32.7123749301
391PhosphorylationGGLQRNKSLSQRLGL
CCCCCCCCHHHHCCC		36.4828889911
393PhosphorylationLQRNKSLSQRLGLGG
CCCCCCHHHHCCCCC		21.9824961812
401PhosphorylationQRLGLGGSGDSNAPM
HHCCCCCCCCCCCCC		37.3127017623
404PhosphorylationGLGGSGDSNAPMTGV
CCCCCCCCCCCCCCH		38.1223749301
409PhosphorylationGDSNAPMTGVRRNLS
CCCCCCCCCHHCCEE		31.3128889911
416PhosphorylationTGVRRNLSLSRDNYD
CCHHCCEEECCCCCC		28.0422369663
418PhosphorylationVRRNLSLSRDNYDVG
HHCCEEECCCCCCCC		33.9222369663
422PhosphorylationLSLSRDNYDVGHSNE
EEECCCCCCCCCCCC		19.1222369663
427PhosphorylationDNYDVGHSNEGVRRS
CCCCCCCCCCCCCCC		30.5523749301
434PhosphorylationSNEGVRRSKTVNSPN
CCCCCCCCCCCCCCC		23.3224961812
435UbiquitinationNEGVRRSKTVNSPNR
CCCCCCCCCCCCCCC		55.4723749301
436PhosphorylationEGVRRSKTVNSPNRT
CCCCCCCCCCCCCCC		26.6024909858
439PhosphorylationRRSKTVNSPNRTHKS
CCCCCCCCCCCCCCC		21.1524909858
445UbiquitinationNSPNRTHKSNYTTDF
CCCCCCCCCCCCCCC		39.5223749301
449PhosphorylationRTHKSNYTTDFDGQD
CCCCCCCCCCCCCCC		24.9219779198
477UbiquitinationRYNEPNMKKKSTGSK
ECCCCCCCCCCHHHH		64.7822817900
478UbiquitinationYNEPNMKKKSTGSKL
CCCCCCCCCCHHHHH		40.9822817900
479UbiquitinationNEPNMKKKSTGSKLL
CCCCCCCCCHHHHHH		47.9722817900
483PhosphorylationMKKKSTGSKLLSRVK
CCCCCHHHHHHHHHH		21.8821440633
484AcetylationKKKSTGSKLLSRVKS
CCCCHHHHHHHHHHH		55.5925381059
484UbiquitinationKKKSTGSKLLSRVKS
CCCCHHHHHHHHHHH		55.5923749301
487PhosphorylationSTGSKLLSRVKSLKV
CHHHHHHHHHHHHHC		45.5221440633
490UbiquitinationSKLLSRVKSLKVGRK
HHHHHHHHHHHCCCC		49.3022817900
493UbiquitinationLSRVKSLKVGRKSQ-
HHHHHHHHCCCCCC-		50.1322817900
497UbiquitinationKSLKVGRKSQ-----
HHHHCCCCCC-----		47.4822817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PAL1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PAL1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PAL1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YM8V_YEASTYMR295Cphysical
10688190
BMH2_YEASTBMH2physical
16554755
HPC2_YEASTHPC2genetic
27708008
PDAT_YEASTLRO1genetic
27708008
IZH2_YEASTIZH2genetic
27708008
SLA1_YEASTSLA1genetic
27708008
PIN4_YEASTPIN4genetic
27708008
SKT5_YEASTSKT5genetic
27708008
ETR1_YEASTETR1genetic
27708008
CSG2_YEASTCSG2genetic
27708008
AGP2_YEASTAGP2genetic
27708008
CHK1_YEASTCHK1genetic
27708008
ELO2_YEASTELO2genetic
27708008
BUD31_YEASTBUD31genetic
27708008
SLX5_YEASTSLX5genetic
27708008
CYK3_YEASTCYK3genetic
27708008
ATG9_YEASTATG9genetic
27708008
ATG1_YEASTATG1genetic
27708008
RS23A_YEASTRPS23Agenetic
27708008
RS23B_YEASTRPS23Agenetic
27708008
SLT2_YEASTSLT2genetic
27708008
BNA3_YEASTBNA3genetic
27708008
BCK1_YEASTBCK1genetic
27708008
RL17B_YEASTRPL17Bgenetic
27708008
HOC1_YEASTHOC1genetic
27708008
AIM26_YEASTAIM26genetic
27708008
PGM1_YEASTPGM1genetic
27708008
DCOR_YEASTSPE1genetic
27708008
DBP7_YEASTDBP7genetic
27708008
UTH1_YEASTUTH1genetic
27708008
ALAM_YEASTALT1genetic
27708008
XDJ1_YEASTXDJ1genetic
27708008
CCW12_YEASTCCW12genetic
27708008
SRN2_YEASTSRN2genetic
27708008
MID2_YEASTMID2genetic
27708008
FKS1_YEASTFKS1genetic
27708008
YL415_YEASTYLR415Cgenetic
27708008
SAM37_YEASTSAM37genetic
27708008
AIP1_YEASTAIP1genetic
27708008
YM11_YEASTEPO1genetic
27708008
MLH1_YEASTMLH1genetic
27708008
NST1_YEASTNST1genetic
27708008
AIM39_YEASTAIM39genetic
27708008
ERP4_YEASTERP4genetic
27708008
EXO1_YEASTEXO1genetic
27708008
MGR2_YEASTMGR2genetic
27708008
TGS1_YEASTTGS1genetic
27708008
YP084_YEASTYPR084Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PAL1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47; SER-49; SER-60;SER-61; SER-64; SER-113; SER-114; SER-149; SER-195 AND SER-197, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; SER-121; SER-195;SER-197 AND THR-199, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND MASSSPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-61; SER-91;SER-92 AND SER-114, AND MASS SPECTROMETRY.

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