DBP7_YEAST - dbPTM
DBP7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DBP7_YEAST
UniProt AC P36120
Protein Name ATP-dependent RNA helicase DBP7
Gene Name DBP7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 742
Subcellular Localization Nucleus, nucleolus .
Protein Description ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs..
Protein Sequence MSDEDSMLLNFTTNEDTAGSSYKQAAKVTGGRWKDRRRMKMKLEGKTVSRKRKANTTGDEGIIPGRGENSIKKLHKESSYSSEEQEKYKGRNAHNTQGRTLPADSQFVSSLFTSNREITTAVNTNIHDENVAINPSNAPLKGDQFASLGVSSLLVSHLEQKMRIKKPTSIQKQAIPQIIGNAGKNDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAFALVIAPTRELASQIYHVCSTLVSCCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQLSQSLRYIVLDEGDKLMELGFDETISEIIKIVHDIPINSEKFPKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLISNGTKKDSDIVTVAPDQLLQRITIVPPKLRLVTLAATLNNITKDFIASGQQSKTLRTIVFVSCSDSVEFHYDAFSGSDGHHKNLTGDSVRLLTKGNTMFPCFSDSRDPDVVIYKLHGSLSQQMRTSTLQHFARDNEATKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAGEKGESLLFLLPGEEEKYMDYIQPYHPMGWELLKFDKEILMPAFKDVNVNRNDKFIRKDEKSSKNKDVGDKEYEWDTNATTWHLNIERRVVGDSAFKNLAVKGFISHVRAYATHISQEKKFFNVKFLHLGHLAKSFGLRERPKAMGLQSSKDGNSEKKPTKENSKNKMFRMARMAEKQIASEFNY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDEDSMLL
------CCHHHCEEE		50.1019795423
6Phosphorylation--MSDEDSMLLNFTT
--CCHHHCEEEECCC		14.8519795423
20PhosphorylationTNEDTAGSSYKQAAK
CCCCCCCCCHHHHHH		28.2019795423
21PhosphorylationNEDTAGSSYKQAAKV
CCCCCCCCHHHHHHH		35.1219795423
22PhosphorylationEDTAGSSYKQAAKVT
CCCCCCCHHHHHHHH		14.6019795423
72AcetylationGRGENSIKKLHKESS
CCCHHHHHHHHHHCC		49.4525381059
76AcetylationNSIKKLHKESSYSSE
HHHHHHHHHCCCCHH		70.5025381059
78PhosphorylationIKKLHKESSYSSEEQ
HHHHHHHCCCCHHHH		39.1025521595
79PhosphorylationKKLHKESSYSSEEQE
HHHHHHCCCCHHHHH		30.0825521595
80PhosphorylationKLHKESSYSSEEQEK
HHHHHCCCCHHHHHH		26.0425521595
81PhosphorylationLHKESSYSSEEQEKY
HHHHCCCCHHHHHHH		32.9728889911
82PhosphorylationHKESSYSSEEQEKYK
HHHCCCCHHHHHHHC		36.6025752575
113PhosphorylationQFVSSLFTSNREITT
HHHHHHHCCCCCEEE		30.3130377154
114PhosphorylationFVSSLFTSNREITTA
HHHHHHCCCCCEEEE		26.9330377154
168PhosphorylationKMRIKKPTSIQKQAI
HHCCCCCCHHHHHHH		47.5528889911
169PhosphorylationMRIKKPTSIQKQAIP
HCCCCCCHHHHHHHC		31.3928889911
198PhosphorylationAQTGSGKTLSYLLPI
EECCCCCHHHHHHHH		25.1827017623
380PhosphorylationSNGTKKDSDIVTVAP
CCCCCCCCCCEEECH		37.8125371407
400AcetylationRITIVPPKLRLVTLA
HCCCCCCHHHHHHHH		39.9224489116
405PhosphorylationPPKLRLVTLAATLNN
CCHHHHHHHHHHHCH		18.4430377154
409PhosphorylationRLVTLAATLNNITKD
HHHHHHHHHCHHCHH		25.1430377154
469PhosphorylationRLLTKGNTMFPCFSD
EEEECCCCEEECCCC		28.9419684113
475PhosphorylationNTMFPCFSDSRDPDV
CCEEECCCCCCCCCE		41.2019684113
477PhosphorylationMFPCFSDSRDPDVVI
EEECCCCCCCCCEEE		37.0719684113
594AcetylationWELLKFDKEILMPAF
HHHHHCCHHHHHHHH		50.1924489116
707PhosphorylationKAMGLQSSKDGNSEK
HHHCCCCCCCCCCCC		23.0827017623
734AcetylationRMARMAEKQIASEFN
HHHHHHHHHHHHHCC		37.1522865919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DBP7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DBP7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DBP7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DBP7_YEASTDBP7physical
14759368
IF2P_YEASTFUN12physical
14759368
MAK21_YEASTMAK21physical
14759368
RRP5_YEASTRRP5physical
14759368
NAT3_YEASTNAT3physical
14759368
DED1_YEASTDED1physical
14759368
DBP6_YEASTDBP6genetic
9582098
FBRL_YEASTNOP1physical
16554755
YRA1_YEASTYRA1physical
16554755
LOC1_YEASTLOC1physical
16554755
RPF2_YEASTRPF2physical
16554755
RRP5_YEASTRRP5physical
16554755
NOP2_YEASTNOP2physical
16554755
RRS1_YEASTRRS1physical
16554755
DBP3_YEASTDBP3physical
16449635
SSB1_YEASTSSB1physical
19536198
LOC1_YEASTLOC1physical
25877921
MAF1_YEASTMAF1genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
ACA2_YEASTCST6genetic
27708008
MGA2_YEASTMGA2genetic
27708008
IRC8_YEASTIRC8genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
RL17B_YEASTRPL17Bgenetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
VRP1_YEASTVRP1genetic
27708008
VPS21_YEASTVPS21genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
LTE1_YEASTLTE1genetic
27708008
ECM1_YEASTECM1genetic
27708008
SHE1_YEASTSHE1genetic
27708008
NU170_YEASTNUP170genetic
27708008
ETR1_YEASTETR1genetic
27708008
TCM62_YEASTTCM62genetic
27708008
ECM33_YEASTECM33genetic
27708008
RPN4_YEASTRPN4genetic
27708008
ACK1_YEASTACK1genetic
27708008
MFG1_YEASTMFG1genetic
27708008
YD042_YEASTYDR042Cgenetic
27708008
ARX1_YEASTARX1genetic
27708008
SWI5_YEASTSWI5genetic
27708008
ODO2_YEASTKGD2genetic
27708008
MNN10_YEASTMNN10genetic
27708008
PAL1_YEASTPAL1genetic
27708008
XRS2_YEASTXRS2genetic
27708008
AP2_YEASTCAD1genetic
27708008
SAP1_YEASTSAP1genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
RGI1_YEASTRGI1genetic
27708008
SWI4_YEASTSWI4genetic
27708008
GCN20_YEASTGCN20genetic
27708008
LSB3_YEASTLSB3genetic
27708008
MIG1_YEASTMIG1genetic
27708008
SGF73_YEASTSGF73genetic
27708008
VAM7_YEASTVAM7genetic
27708008
CUL3_YEASTCUL3genetic
27708008
SLX9_YEASTSLX9genetic
27708008
RSSA1_YEASTRPS0Agenetic
27708008
TNA1_YEASTTNA1genetic
27708008
GGA2_YEASTGGA2genetic
27708008
AGE2_YEASTAGE2genetic
27708008
HPM1_YEASTHPM1genetic
27708008
THIK_YEASTPOT1genetic
27708008
MET28_YEASTMET28genetic
27708008
LPLA_YEASTAIM22genetic
27708008
YJH0_YEASTYJL070Cgenetic
27708008
YJ85_YEASTYJR115Wgenetic
27708008
STE24_YEASTSTE24genetic
27708008
YL032_YEASTYLL032Cgenetic
27708008
VPS13_YEASTVPS13genetic
27708008
SDHB_YEASTSDH2genetic
27708008
ATG10_YEASTATG10genetic
27708008
FPS1_YEASTFPS1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
LOT6_YEASTLOT6genetic
27708008
POM34_YEASTPOM34genetic
27708008
ENV10_YEASTENV10genetic
27708008
CSF1_YEASTCSF1genetic
27708008
CHA4_YEASTCHA4genetic
27708008
SRN2_YEASTSRN2genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
RSA3_YEASTRSA3genetic
27708008
LIPB_YEASTLIP2genetic
27708008
SYM1_YEASTSYM1genetic
27708008
SPO77_YEASTSPO77genetic
27708008
FKS1_YEASTFKS1genetic
27708008
ROM2_YEASTROM2genetic
27708008
ECM7_YEASTECM7genetic
27708008
MSC1_YEASTMSC1genetic
27708008
YMS4_YEASTYMR034Cgenetic
27708008
IOC4_YEASTIOC4genetic
27708008
ZRC1_YEASTZRC1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
HDA1_YEASTHDA1genetic
27708008
FKBP_YEASTFPR1genetic
27708008
ATG3_YEASTATG3genetic
27708008
BRE5_YEASTBRE5genetic
27708008
MSN1_YEASTMSN1genetic
27708008
TRM11_YEASTTRM11genetic
27708008
RRP6_YEASTRRP6genetic
27708008
BUB3_YEASTBUB3genetic
27708008
PMT3_YEASTPMT3genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
ATG21_YEASTATG21genetic
27708008
FMP30_YEASTFMP30genetic
27708008
KIP2_YEASTKIP2genetic
27708008
AIM44_YEASTAIM44genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DBP7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, AND MASSSPECTROMETRY.

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