SYM1_YEAST - dbPTM
SYM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYM1_YEAST
UniProt AC Q06563
Protein Name Protein SYM1
Gene Name SYM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 197
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein .
Protein Description May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability. Required for ethanol metabolism and tolerance during heat shock..
Protein Sequence MKLLHLYEASLKRRPKTTNAIMTGALFGIGDVSAQLLFPTSKVNKGYDYKRTARAVIYGSLIFSFIGDKWYKILNNKIYMRNRPQYHWSNMVLRVAVDQLAFAPLGLPFYFTCMSIMEGRSFDVAKLKIKEQWWPTLLTNWAVWPLFQAINFSVVPLQHRLLAVNVVAIFWNTYLSYKNSKVMEKDKVPVHYPPVVE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MKLLHLYEASLKRR
-CCHHHHHHHHHCCC		9.9419823750
10PhosphorylationLLHLYEASLKRRPKT
HHHHHHHHHCCCCCC		23.6019823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YMC1_YEASTYMC1genetic
20042463
ODC1_YEASTODC1genetic
20042463
CISY1_YEASTCIT1genetic
20042463
CISY2_YEASTCIT2genetic
20042463
REI1_YEASTREI1genetic
20093466
RV161_YEASTRVS161genetic
20093466
DCOR_YEASTSPE1genetic
20093466
RL14A_YEASTRPL14Agenetic
20093466
DNM1_YEASTDNM1genetic
20093466
RSSA2_YEASTRPS0Bgenetic
20093466
BRE5_YEASTBRE5genetic
20093466
YAR1_YEASTYAR1genetic
20093466
RL21B_YEASTRPL21Bgenetic
20093466
TOM22_YEASTTOM22physical
23045398
TOM40_YEASTTOM40physical
23045398
TOM20_YEASTTOM20physical
23045398
TOM5_YEASTTOM5physical
23045398
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYM1_YEAST

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Related Literatures of Post-Translational Modification

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