TOM40_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOM40_YEAST
• UniProt AC: P23644
• Protein Name: Mitochondrial import receptor subunit TOM40
• Gene Name: TOM40
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 387
• Subcellular Localization: Mitochondrion outer membrane; Multi-pass membrane protein.
• Protein Description: Channel-forming protein essential for import of protein precursors into mitochondria..
• Protein Sequence: MSAPTPLAEASQIPTIPALSPLTAKQSKGNFFSSNPISSFVVDTYKQLHSHRQSLELVNPGTVENLNKEVSRDVFLSQYFFTGLRADLNKAFSMNPAFQTSHTFSIGSQALPKYAFSALFANDNLFAQGNIDNDLSVSGRLNYGWDKKNISKVNLQISDGQPTMCQLEQDYQASDFSVNVKTLNPSFSEKGEFTGVAVASFLQSVTPQLALGLETLYSRTDGSAPGDAGVSYLTRYVSKKQDWIFSGQLQANGALIASLWRKVAQNVEAGIETTLQAGMVPITDPLMGTPIGIQPTVEGSTTIGAKYEYRQSVYRGTLDSNGKVACFLERKVLPTLSVLFCGEIDHFKNDTKIGCGLQFETAGNQELLMLQQGLDADGNPLQALPQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAPTPLAE ------CCCCCCHHH	42.85	30377154
11	Phosphorylation	PTPLAEASQIPTIPA CCCHHHHHCCCCCCC	21.83	30377154
15	Phosphorylation	AEASQIPTIPALSPL HHHHCCCCCCCCCCC	41.02	30377154
27	Phosphorylation	SPLTAKQSKGNFFSS CCCCCCCCCCCCCCC	41.65	30377154
46	Acetylation	SFVVDTYKQLHSHRQ HHHHHHHHHHHHHHH	48.77	24489116
68	Acetylation	GTVENLNKEVSRDVF CHHHHHCHHHCHHHH	63.76	24489116
147	Acetylation	RLNYGWDKKNISKVN CEECCCCCCCEEEEE	41.01	22865919
231	Phosphorylation	APGDAGVSYLTRYVS CCCCHHHHHHHHHHC	17.32	15665377

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOM40_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOM40_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOM40_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOM20_YEAST	TOM20	physical	9774667
TOM22_YEAST	TOM22	physical	9774667
VDAC1_YEAST	POR1	physical	11266446
NDK_YEAST	YNK1	physical	12472466
TOM40_YEAST	TOM40	physical	11336653
BCS1_YEAST	BCS1	physical	12640110
TOM22_YEAST	TOM22	physical	8754801
TOM20_YEAST	TOM20	physical	10427088
TOM20_YEAST	TOM20	physical	8641278
TOM22_YEAST	TOM22	physical	8641278
TOM70_YEAST	TOM70	physical	9217162
VDAC1_YEAST	POR1	physical	9217162
TOM20_YEAST	TOM20	physical	9217162
TOM22_YEAST	TOM22	physical	9217162
TOM5_YEAST	TOM5	physical	9217162
TOM70_YEAST	TOM70	physical	9774667
TOM6_YEAST	TOM6	genetic	8344244
RPM2_YEAST	RPM2	genetic	11404323
RPM2_YEAST	RPM2	genetic	16024791
RPM2_YEAST	RPM2	genetic	7544434
TOM70_YEAST	TOM70	physical	1327874
TOM20_YEAST	TOM20	physical	1327874
TOM22_YEAST	TOM22	physical	1327874
SAM35_YEAST	SAM35	physical	18358813
SAM50_YEAST	SAM50	physical	18358813
VDAC1_YEAST	POR1	physical	17978093
VDAC2_YEAST	POR2	physical	17978093
TOM70_YEAST	TOM70	physical	17978093
TOM20_YEAST	TOM20	physical	17978093
TIM23_YEAST	TIM23	physical	17978093
PEX3_YEAST	PEX3	physical	16093310
SAM35_YEAST	SAM35	physical	20026336
SAM37_YEAST	SAM37	physical	20026336
TOM20_YEAST	TOM20	physical	20026336
SAM50_YEAST	SAM50	physical	21680715
SAM35_YEAST	SAM35	physical	21680715
SAM37_YEAST	SAM37	physical	21680715
MDM10_YEAST	MDM10	physical	21680715
UGO1_YEAST	UGO1	physical	21825073
TOM70_YEAST	TOM70	physical	21825073
TOM22_YEAST	TOM22	physical	21825073
PSD1_YEAST	PSD1	physical	22984266
ATP9_NEUCR	NCU02250	physical	21173275
TAZ1_YEAST	TAZ1	physical	24078306
TOM22_YEAST	TOM22	physical	25318675
TOM5_YEAST	TOM5	physical	25318675
TOM70_YEAST	TOM70	physical	25318675
TOM20_YEAST	TOM20	physical	25318675
TOM22_YEAST	TOM22	physical	26404837
TIM10_YEAST	TIM10	physical	26404837
TOM7_YEAST	TOM7	physical	26404837

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.