PEX3_YEAST - dbPTM
PEX3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PEX3_YEAST
UniProt AC P28795
Protein Name Peroxisomal biogenesis factor 3
Gene Name PEX3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 441
Subcellular Localization Peroxisome membrane
Single-pass membrane protein.
Protein Description Involved in peroxisome biosynthesis. May function as a receptor protein. Lack of this protein causes the peroxisomal-deficient phenotype and mislocalization in the cytosol of peroxisomal matrix proteins..
Protein Sequence MAPNQRSRSLLQRHRGKVLISLTGIAALFTTGSVVVFFVKRWLYKQQLRITEQHFIKEQIKRRFEQTQEDSLYTIYELLPVWRMVLNENDLNLDSIVTQLKDQKNQLTRAKSSESRESSPLKSKAELWNELELKSLIKLVTVTYTVSSLILLTRLQLNILTRNEYLDSAIKLTMQQENCNKLQNRFYNWVTSWWSDPEDKADDAMVMAAKKSKKEGQEVYINEQAFLSLSWWILNKGWLSYNEIITNQIEIEFDGIHPRDTLTLEEFSSRLTNIFRNTNSQIFQQNNNNLTSILLPKDSSGQEFLLSQTLDADALTSFHSNTLVFNQLVNELTQCIESTATSIVLESLINESFHFIMNKVGIKTIAKKKPGQEDQQQYQMAVFAMSMKDCCQEMLQTTAGSSHSGSVNEYLATLDSVQPLDDLSASVYSNFGVSSSFSFKP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
108PhosphorylationKDQKNQLTRAKSSES
HHHHHHHHHHHCCCC		20.8621440633
112PhosphorylationNQLTRAKSSESRESS
HHHHHHHCCCCCCCC		38.0529136822
113PhosphorylationQLTRAKSSESRESSP
HHHHHHCCCCCCCCC		38.5929136822
115PhosphorylationTRAKSSESRESSPLK
HHHHCCCCCCCCCCC		43.2129136822
118PhosphorylationKSSESRESSPLKSKA
HCCCCCCCCCCCCHH		35.8229136822
119PhosphorylationSSESRESSPLKSKAE
CCCCCCCCCCCCHHH		29.5124961812
181UbiquitinationMQQENCNKLQNRFYN
HCHHHHHHHHHHHHH		54.3623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PEX3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PEX3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PEX3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PEX11_YEASTPEX11physical
10087260
PEX14_YEASTPEX14physical
10087260
PEX11_YEASTPEX11physical
18467557
PEX25_YEASTPEX25physical
18467557
PEX3_YEASTPEX3physical
19822674
PEX19_YEASTPEX19physical
19017643
INP1_YEASTINP1physical
19948495
PEX19_YEASTPEX19physical
19948495
ATG8_YEASTATG8genetic
20093466
ODPB_YEASTPDB1genetic
20093466
TXTP_YEASTCTP1genetic
20093466
BUD31_YEASTBUD31genetic
20093466
HMO1_YEASTHMO1genetic
20093466
XRN1_YEASTXRN1genetic
20093466
PEF1_YEASTPEF1genetic
20093466
YG35_YEASTYGR125Wgenetic
20093466
NPR3_YEASTNPR3genetic
20093466
LPLA_YEASTAIM22genetic
20093466
GEF1_YEASTGEF1genetic
20093466
PFD6_YEASTYKE2genetic
20093466
SRR1L_YEASTBER1genetic
20093466
LEUR_YEASTLEU3genetic
20093466
NU188_YEASTNUP188genetic
20093466
SAM37_YEASTSAM37genetic
20093466
PO152_YEASTPOM152genetic
20093466
RAD14_YEASTRAD14genetic
20093466
ODP2_YEASTLAT1genetic
20093466
MED9_YEASTCSE2genetic
20093466
PT127_YEASTPET127genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
PEX3_YEASTPEX3physical
12876220
PEX15_YEASTPEX15physical
12876220
PEX13_YEASTPEX13physical
12876220
ATG36_YEASTATG36physical
22643220
PEX19_YEASTPEX19physical
22643220
ATG1_YEASTATG1genetic
22643220
PEX19_YEASTPEX19physical
19451657
PEX19_YEASTPEX19genetic
23891562
PEX13_YEASTPEX13genetic
23891562
PEX12_YEASTPEX12genetic
23891562
RV161_YEASTRVS161genetic
23891562
ICE2_YEASTICE2genetic
23891562
THIK_YEASTPOT1genetic
23755917
ATG1_YEASTATG1genetic
23755917
INP1_YEASTINP1physical
23900285
KPC1_YEASTPKC1genetic
27708008
CDC53_YEASTCDC53genetic
27708008
CDC4_YEASTCDC4genetic
27708008
CDC12_YEASTCDC12genetic
27708008
CH10_YEASTHSP10genetic
27708008
EI2BG_YEASTGCD1genetic
27708008
ATG8_YEASTATG8genetic
27708008
ODPB_YEASTPDB1genetic
27708008
CLPX_YEASTMCX1genetic
27708008
TXTP_YEASTCTP1genetic
27708008
THRC_YEASTTHR4genetic
27708008
BUD31_YEASTBUD31genetic
27708008
VMS1_YEASTVMS1genetic
27708008
ODO2_YEASTKGD2genetic
27708008
RS26B_YEASTRPS26Bgenetic
27708008
ODPA_YEASTPDA1genetic
27708008
RPN14_YEASTRPN14genetic
27708008
ATG1_YEASTATG1genetic
27708008
RS23A_YEASTRPS23Agenetic
27708008
RS23B_YEASTRPS23Agenetic
27708008
NPR3_YEASTNPR3genetic
27708008
HPM1_YEASTHPM1genetic
27708008
LPLA_YEASTAIM22genetic
27708008
GEF1_YEASTGEF1genetic
27708008
PFD6_YEASTYKE2genetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
SRR1L_YEASTBER1genetic
27708008
LEUR_YEASTLEU3genetic
27708008
NU188_YEASTNUP188genetic
27708008
SAM37_YEASTSAM37genetic
27708008
ODP2_YEASTLAT1genetic
27708008
ATG3_YEASTATG3genetic
27708008
LEO1_YEASTLEO1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
BECN1_YEASTVPS30genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PEX3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-118, ANDMASS SPECTROMETRY.

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