YG35_YEAST - dbPTM
YG35_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YG35_YEAST
UniProt AC P53273
Protein Name Uncharacterized vacuolar membrane protein YGR125W
Gene Name YGR125W
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1036
Subcellular Localization Vacuole membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MGRTIRRRRSNSSLSEAISVSLGINQDSSVNKMHRASVSAMSPPLCRSYMSGFFTGGNSPMINNLSDSKLPISNKQHPKVIHGSENLHRQTAQLSNEFCSSSVEENSPTIKDYMDIIGNGDRKDDQSMRTIEENIDEEYSDEYSRLLLSPASSNVDDDRNRGLQNSSLPELEDGYAGGYQSLRPSHNLRFRPRNLWHMCTSFPSKFAHYLPAAVLGLLLNILDALSYGMIIFPITEPVFSHLGPTGISMFYISTIISQAVYSGGWSSFPSGIGSEMIEITPFYHTMALAIKEALAGNDDEIITTTIFCYVISSMLTGVVFYALGKLRLGKIVGFFPRHILIGCIGGVGYFLIITGIEVTTRVAKFEYSWPFFSGLFTDYDTLAKWLLPVLLTVVLIGTQRYFKNSLVLPSFYILTLVLFHFIVAIIPTLSLDALRQAGWIFPIANSDSKWYDHYRLFNVHKVHWSLVLQQIPTMMALTFFGILHVPINVPALAMSLQMDKYDVDRELIAHGYSNFFSGLLGSVQNYLVYTNSVLFIRAGADSPFAGFLLIALTICIMIIGPVIISFIPICIVGSLIFLLGYELLVEALVDTWNKLNRFEYLTVVIIVFTMGIFDFVLGIIVGILIACFSFLVDSTKLQTINGEYNGNVARSTVYRDYVQTKFLDGIGEQIYVLKLQNLLFFGTIISIEEKIERLLQISNKDATKRRIKYLILDFKNINADNIDYSAAEGFNRIKRFTETKRIKLIISSIKERDRIYNAFNNVGLLNDVELFADLNSALEWCENEFLFQYKQLRKKAKERLEEGKQNNVVSAVIAATKNKKIDTIGNGLNRGSNGDTARNLMSLPTNTPRNYQILSVAQNVFVNDEQAVKNFKKEYKDDEPVLPILLFALKQYRPDIISEVQKVREKEIKFWAQLCPYFTRRRLASQSHLLHADNIFFLVETGMLKATYELPQGTLYEIFSNGTCFGKIIAPGNAMPREQKLTIETETDSVLWVIDSSSLNKLKEDNLALYVEVALMVMCIKDTRFKELLGYTLVSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37PhosphorylationVNKMHRASVSAMSPP
CCHHHHCHHCCCCCH		19.3025704821
39PhosphorylationKMHRASVSAMSPPLC
HHHHCHHCCCCCHHH		18.7628889911
42PhosphorylationRASVSAMSPPLCRSY
HCHHCCCCCHHHHHH		24.0721082442
48PhosphorylationMSPPLCRSYMSGFFT
CCCHHHHHHHCCCCC		24.9630377154
55PhosphorylationSYMSGFFTGGNSPMI
HHHCCCCCCCCCCCC		41.7523749301
59PhosphorylationGFFTGGNSPMINNLS
CCCCCCCCCCCCCCC		21.0821440633
66PhosphorylationSPMINNLSDSKLPIS
CCCCCCCCCCCCCCC		41.8023749301
73PhosphorylationSDSKLPISNKQHPKV
CCCCCCCCCCCCCCE		35.7121440633
84PhosphorylationHPKVIHGSENLHRQT
CCCEECCCCCHHHHH		14.7821551504
95PhosphorylationHRQTAQLSNEFCSSS
HHHHHHHCHHHHHCC		23.4121551504
100PhosphorylationQLSNEFCSSSVEENS
HHCHHHHHCCCCCCC		30.8521440633
101PhosphorylationLSNEFCSSSVEENSP
HCHHHHHCCCCCCCC		39.3121440633
102PhosphorylationSNEFCSSSVEENSPT
CHHHHHCCCCCCCCC		19.7721440633
107PhosphorylationSSSVEENSPTIKDYM
HCCCCCCCCCHHHHH		27.0521440633
127PhosphorylationGDRKDDQSMRTIEEN
CCCCCCHHCHHHHHH		19.7528889911
130PhosphorylationKDDQSMRTIEENIDE
CCCHHCHHHHHHCCH		24.8928889911
139PhosphorylationEENIDEEYSDEYSRL
HHHCCHHHCHHHHHH		21.2628889911
140PhosphorylationENIDEEYSDEYSRLL
HHCCHHHCHHHHHHH		27.5222369663
143PhosphorylationDEEYSDEYSRLLLSP
CHHHCHHHHHHHCCC		12.2328889911
144PhosphorylationEEYSDEYSRLLLSPA
HHHCHHHHHHHCCCC		17.8828889911
149PhosphorylationEYSRLLLSPASSNVD
HHHHHHCCCCCCCCC		20.5622369663
152PhosphorylationRLLLSPASSNVDDDR
HHHCCCCCCCCCCCC		26.3222369663
153PhosphorylationLLLSPASSNVDDDRN
HHCCCCCCCCCCCCC		42.8722369663
368PhosphorylationRVAKFEYSWPFFSGL
EEEEECCCCCCCCCC		22.5219779198
379PhosphorylationFSGLFTDYDTLAKWL
CCCCCCCHHHHHHHH		14.0419779198
381PhosphorylationGLFTDYDTLAKWLLP
CCCCCHHHHHHHHHH		23.5319779198
700UbiquitinationRLLQISNKDATKRRI
HHHHHCCHHHHHHHH		41.7823749301
715UbiquitinationKYLILDFKNINADNI
HEEEEECCCCCCCCC		57.4917644757
804UbiquitinationKERLEEGKQNNVVSA
HHHHHHHHHCCHHHH		53.8023749301
816PhosphorylationVSAVIAATKNKKIDT
HHHHHHHHCCCCCCC		26.5723749301
820UbiquitinationIAATKNKKIDTIGNG
HHHHCCCCCCCCCCC		56.0323749301
823PhosphorylationTKNKKIDTIGNGLNR
HCCCCCCCCCCCCCC		33.9728889911
832PhosphorylationGNGLNRGSNGDTARN
CCCCCCCCCCHHHHH		34.1129136822
836PhosphorylationNRGSNGDTARNLMSL
CCCCCCHHHHHHHCC		28.9929136822
842PhosphorylationDTARNLMSLPTNTPR
HHHHHHHCCCCCCCC		34.0717330950
845PhosphorylationRNLMSLPTNTPRNYQ
HHHHCCCCCCCCCCE		57.9524909858
847PhosphorylationLMSLPTNTPRNYQIL
HHCCCCCCCCCCEEE		26.5517330950
892PhosphorylationLLFALKQYRPDIISE
HHHHHHHHCCCHHHH		23.6428889911
909UbiquitinationKVREKEIKFWAQLCP
HHHHHHHHHHHHHCH		35.6317644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YG35_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YG35_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YG35_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG8_YEASTATG8genetic
20093466
AIM4_YEASTAIM4genetic
20093466
HSP30_YEASTHSP30genetic
20093466
SNT1_YEASTSNT1genetic
20093466
CSM1_YEASTCSM1genetic
20093466
PP2A1_YEASTPPH21genetic
20093466
BRE1_YEASTBRE1genetic
20093466
RT103_YEASTRTT103genetic
20093466
OMS1_YEASTOMS1genetic
20093466
PEX3_YEASTPEX3genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
BUD27_YEASTBUD27genetic
20093466
ADY1_YEASTPFS1genetic
20093466
TOF2_YEASTTOF2genetic
20093466
FPS1_YEASTFPS1genetic
20093466
SCS7_YEASTSCS7genetic
20093466
PHO23_YEASTPHO23genetic
20093466
RHO2_YEASTRHO2genetic
20093466
IDH1_YEASTIDH1genetic
20093466
PEX15_YEASTPEX15genetic
20093466
WHI2_YEASTWHI2genetic
20093466
WHI5_YEASTWHI5genetic
20093466
FYV12_YEASTFYV12genetic
20093466
DSE3_YEASTDSE3genetic
20093466
CG22_YEASTCLB2genetic
20093466
FOLE_YEASTMET7genetic
21623372
SPEE_YEASTSPE3genetic
21623372
KAD2_YEASTADK1genetic
21623372
DCAM_YEASTSPE2genetic
21623372
CSG2_YEASTCSG2genetic
21623372
CYS3_YEASTCYS3genetic
21623372
ADH3_YEASTADH3genetic
21623372
AVT4_YEASTAVT4genetic
21623372
DCOR_YEASTSPE1genetic
21623372
MDHP_YEASTMDH3genetic
21623372
ARO1_YEASTARO1genetic
21623372
KCS1_YEASTKCS1genetic
21623372
COQ3_YEASTCOQ3genetic
21623372
TFC3_YEASTTFC3genetic
27708008
MAK16_YEASTMAK16genetic
27708008
APC11_YEASTAPC11genetic
27708008
RPB1_YEASTRPO21genetic
27708008
RPC10_YEASTRPC11genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
UTP5_YEASTUTP5genetic
27708008
GPI19_YEASTGPI19genetic
27708008
SYFB_YEASTFRS1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
GPI12_YEASTGPI12genetic
27708008
NOP2_YEASTNOP2genetic
27708008
AIM4_YEASTAIM4genetic
27708008
SFL1_YEASTSFL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YG35_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-101; TYR-139;SER-140; SER-144; SER-149; SER-152; SER-153; SER-842; THR-847 ANDTYR-892, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152 AND SER-153, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-149; SER-152;SER-153; SER-842 AND THR-847, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-140, AND MASSSPECTROMETRY.

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