TOF2_YEAST - dbPTM
TOF2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TOF2_YEAST
UniProt AC Q02208
Protein Name Topoisomerase 1-associated factor 2
Gene Name TOF2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 771
Subcellular Localization Nucleus .
Protein Description
Protein Sequence MIKMWRLQIVLVPPSAQDIITFLEARLNTPQSVSPMVQYNEDIITHNNSINNCSDPSPTSPSSQNSIQSNRSSDFINYLPNCKKFLHFTDGDNTLLQLSNEILTKFDRLYPNFKESIEIVSLQDRHGCDLDSEFIIKDVFENDGVVLVILKDELDWSRNQHISLLQLARQRRRQDNKPSTKSIVTEKRKKISKEDLSSISNKDTMHLIAKSSLKNNFINKSRVSTPLMNEILPLASKYDALNKEKCPMPLTSTVVASNVHKDVKDHARAKEGVVTQGSDNNKENIPSSTQQQKNDGAKRAESKDLDLLRNSSEDADYEPADENSPQISFDSIDTDFQLSTTSHTNSDMHIQYSNPSSGAHSPRKSSLEIKVQNKKGDDLPLNDKDIGENCRRIEAFSDEEDFNETDNDRADSFINNSKKASMGFRDINSDLDSVSFNSDIENAVQSTQSTKNVVSPPFFPEKELNNRLHQSQGKEALFRLVEKEFPDKSLGAASSTSHAKDVKIQETIRKLNRFKPTGETKVQKRNSITEPYYGKFGIMKKDKPKSITSKGVSLETKHFDDPNTIISGEKFAKFGKIKVKRKTDDVGSKVIEFKRKRNMGNRSLKDIFANAGKPPNAASTIKVVKLMRDPVDNSKDKVEATSNSTAQEQEQVSPKLPVMNSTPGKRKNGQAIPSSLERTPQLKKVKVTRSHSSPSSSSSMSLESSLDSSSSDDSDDDSDSRNVQVKKINFKTSHGPAGNSNGKPMLDVDDNEINTKKYQTPKYVESDEDDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
72PhosphorylationNSIQSNRSSDFINYL
HHHHCCCCHHHHHHC		38.2128889911
73PhosphorylationSIQSNRSSDFINYLP
HHHCCCCHHHHHHCC		33.0529734811
221PhosphorylationKNNFINKSRVSTPLM
HHCCCCHHHCCCHHH		33.1721440633
225PhosphorylationINKSRVSTPLMNEIL
CCHHHCCCHHHHHHH		19.9921440633
365PhosphorylationGAHSPRKSSLEIKVQ
CCCCCCCCCCEEEEE		41.2430377154
366PhosphorylationAHSPRKSSLEIKVQN
CCCCCCCCCEEEEEC		32.8125704821
397PhosphorylationCRRIEAFSDEEDFNE
HHEECCCCCHHHCCC		51.6821551504
405PhosphorylationDEEDFNETDNDRADS
CHHHCCCCCCHHHHH		41.0028889911
412PhosphorylationTDNDRADSFINNSKK
CCCHHHHHHHHHCHH		27.3528889911
429PhosphorylationMGFRDINSDLDSVSF
CCCCCCCCCCCCCCC		39.6321551504
433PhosphorylationDINSDLDSVSFNSDI
CCCCCCCCCCCCHHH		27.2720377248
435PhosphorylationNSDLDSVSFNSDIEN
CCCCCCCCCCHHHHH		23.7430377154
438PhosphorylationLDSVSFNSDIENAVQ
CCCCCCCHHHHHHHH		37.6421551504
455PhosphorylationQSTKNVVSPPFFPEK
CCCCCCCCCCCCCHH		23.6728889911
462AcetylationSPPFFPEKELNNRLH
CCCCCCHHHHHHHHH		68.6724489116
483AcetylationALFRLVEKEFPDKSL
HHHHHHHHHCCCCCC		58.1225381059
489PhosphorylationEKEFPDKSLGAASST
HHHCCCCCCCCCCCC		39.1421440633
500AcetylationASSTSHAKDVKIQET
CCCCCHHHHHHHHHH		58.5925381059
527PhosphorylationTKVQKRNSITEPYYG
CCCEECCCCCCCCCC		34.6121551504
529PhosphorylationVQKRNSITEPYYGKF
CEECCCCCCCCCCCC		30.6319779198
557AcetylationKGVSLETKHFDDPNT
CCCCCEEECCCCCCC		32.6624489116
634PhosphorylationMRDPVDNSKDKVEAT
CCCCCCCCCCCEEEC		37.4521551504
644PhosphorylationKVEATSNSTAQEQEQ
CEEECCCCCHHHHHH		25.5321551504
645PhosphorylationVEATSNSTAQEQEQV
EEECCCCCHHHHHHH		36.2924961812
653PhosphorylationAQEQEQVSPKLPVMN
HHHHHHHCCCCCCCC		18.9328889911
661PhosphorylationPKLPVMNSTPGKRKN
CCCCCCCCCCCCCCC		20.2024961812
662PhosphorylationKLPVMNSTPGKRKNG
CCCCCCCCCCCCCCC		30.9321440633
674PhosphorylationKNGQAIPSSLERTPQ
CCCCCCCCCCCCCCC		41.2521440633
679PhosphorylationIPSSLERTPQLKKVK
CCCCCCCCCCCCEEE		13.1521440633
763PhosphorylationKKYQTPKYVESDEDD
CCCCCCCCCCCCCCC		15.6222890988
766PhosphorylationQTPKYVESDEDDQ--
CCCCCCCCCCCCC--		35.9322890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TOF2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TOF2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TOF2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HPR1_YEASTHPR1genetic
10028183
TOP1_YEASTTOP1genetic
10028183
MLC1_YEASTMLC1physical
16554755
SAC3_YEASTSAC3genetic
17314980
CIN8_YEASTCIN8genetic
17314980
PAT1_YEASTPAT1genetic
17314980
HOS2_YEASTHOS2genetic
17314980
HCS1_YEASTHCS1genetic
17314980
BIM1_YEASTBIM1genetic
17314980
SLX5_YEASTSLX5genetic
17314980
ARO1_YEASTARO1genetic
17314980
TAF12_YEASTTAF12genetic
17314980
PCNA_YEASTPOL30genetic
17314980
NET1_YEASTNET1physical
17043313
CDC14_YEASTCDC14physical
17043313
FOB1_YEASTFOB1physical
17043313
SIR2_YEASTSIR2physical
17043313
H4_YEASTHHF1physical
17043313
LRS4_YEASTLRS4physical
17043313
CSM1_YEASTCSM1physical
17043313
RTN1_YEASTRTN1physical
17043313
CSM1_YEASTCSM1physical
18719252
SSB1_YEASTSSB1physical
19536198
CDC14_YEASTCDC14physical
18595708
CDC14_YEASTCDC14genetic
18595708
LTE1_YEASTLTE1genetic
20093466
YAJ9_YEASTYAR029Wgenetic
20093466
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
PLPHP_YEASTYBL036Cgenetic
20093466
RL19A_YEASTRPL19Bgenetic
20093466
RL19B_YEASTRPL19Bgenetic
20093466
PYC2_YEASTPYC2genetic
20093466
CHK1_YEASTCHK1genetic
20093466
PAT1_YEASTPAT1genetic
20093466
RLA1_YEASTRPP1Agenetic
20093466
SAC3_YEASTSAC3genetic
20093466
PEX10_YEASTPEX10genetic
20093466
RT103_YEASTRTT103genetic
20093466
RV167_YEASTRVS167genetic
20093466
CAJ1_YEASTCAJ1genetic
20093466
PP2C2_YEASTPTC2genetic
20093466
SCS2_YEASTSCS2genetic
20093466
YG35_YEASTYGR125Wgenetic
20093466
ICE2_YEASTICE2genetic
20093466
FIS1_YEASTFIS1genetic
20093466
YIT6_YEASTYIR016Wgenetic
20093466
MRX5_YEASTYJL147Cgenetic
20093466
YJ24_YEASTKCH1genetic
20093466
CBT1_YEASTCBT1genetic
20093466
HAP4_YEASTHAP4genetic
20093466
RL22A_YEASTRPL22Agenetic
20093466
SWI6_YEASTSWI6genetic
20093466
COX8_YEASTCOX8genetic
20093466
SST2_YEASTSST2genetic
20093466
CIK1_YEASTCIK1genetic
20093466
AEP2_YEASTAEP2genetic
20093466
RAS2_YEASTRAS2genetic
20093466
SWS2_YEASTSWS2genetic
20093466
ODP2_YEASTLAT1genetic
20093466
COQ2_YEASTCOQ2genetic
20093466
YO08A_YEASTYOR008C-Agenetic
20093466
ASE1_YEASTASE1genetic
20093466
RDL2_YEASTRDL2genetic
20093466
SFG1_YEASTSFG1genetic
20093466
MNE1_YEASTMNE1genetic
20093466
YP245_YEASTYPL245Wgenetic
20093466
JID1_YEASTJID1genetic
20093466
QCR2_YEASTQCR2genetic
20093466
CHK1_YEASTCHK1genetic
22282571
DAL81_YEASTDAL81genetic
27708008
VPS53_YEASTVPS53genetic
27708008
SWI6_YEASTSWI6genetic
27708008
PALA_YEASTRIM20genetic
27708008
MNE1_YEASTMNE1genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
PAT1_YEASTPAT1genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
SAC3_YEASTSAC3genetic
27708008
UME6_YEASTUME6genetic
27708008
PMP3_YEASTPMP3genetic
27708008
SNF1_YEASTSNF1genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
PP2C2_YEASTPTC2genetic
27708008
SCS2_YEASTSCS2genetic
27708008
FIS1_YEASTFIS1genetic
27708008
ICE2_YEASTICE2genetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
YJ24_YEASTKCH1genetic
27708008
MOG1_YEASTMOG1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
COXM1_YEASTCMC1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
CBT1_YEASTCBT1genetic
27708008
COA4_YEASTCOA4genetic
27708008
NKP2_YEASTNKP2genetic
27708008
ATP10_YEASTATP10genetic
27708008
COX8_YEASTCOX8genetic
27708008
SST2_YEASTSST2genetic
27708008
MSS1_YEASTMSS1genetic
27708008
RCO1_YEASTRCO1genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
AEP2_YEASTAEP2genetic
27708008
SIW14_YEASTSIW14genetic
27708008
SWS2_YEASTSWS2genetic
27708008
RAS2_YEASTRAS2genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
HMI1_YEASTHMI1genetic
27708008
HST3_YEASTHST3genetic
27708008
ASE1_YEASTASE1genetic
27708008
CY1_YEASTCYT1genetic
27708008
SFG1_YEASTSFG1genetic
27708008
KIP2_YEASTKIP2genetic
27708008
COX10_YEASTCOX10genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
YP245_YEASTYPL245Wgenetic
27708008
JID1_YEASTJID1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
QCR2_YEASTQCR2genetic
27708008
CTF4_YEASTCTF4physical
27397685
CDC45_YEASTCDC45physical
27397685
SLD5_YEASTSLD5physical
27397685
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TOF2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-397, AND MASSSPECTROMETRY.

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