HCS1_YEAST - dbPTM
HCS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HCS1_YEAST
UniProt AC P34243
Protein Name DNA polymerase alpha-associated DNA helicase A
Gene Name HCS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 683
Subcellular Localization Cytoplasm . Nucleus .
Protein Description DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication..
Protein Sequence MNKELASKFLSSIKHEREQDIQTTSRLLTTLSIQQLVQNGLAINNIHLENIRSGLIGKLYMELGPNLAVNDKIQRGDIKVGDIVLVRPAKTKVNTKTKPKVKKVSEDSNGEQAECSGVVYKMSDTQITIALEESQDVIATTFYSYSKLYILKTTNVVTYNRMESTMRKLSEISSPIQDKIIQYLVNERPFIPNTNSFQNIKSFLNPNLNDSQKTAINFAINNDLTIIHGPPGTGKTFTLIELIQQLLIKNPEERILICGPSNISVDTILERLTPLVPNNLLLRIGHPARLLDSNKRHSLDILSKKNTIVKDISQEIDKLIQENKKLKNYKQRKENWNEIKLLRKDLKKREFKTIKDLIIQSRIVVTTLHGSSSRELCSLYRDDPNFQLFDTLIIDEVSQAMEPQCWIPLIAHQNQFHKLVLAGDNKQLPPTIKTEDDKNVIHNLETTLFDRIIKIFPKRDMVKFLNVQYRMNQKIMEFPSHSMYNGKLLADATVANRLLIDLPTVDATPSEDDDDTKIPLIWYDTQGDEFQETADEATILGSKYNEGEIAIVKEHIENLRSFNVPENSIGVISPYNAQVSHLKKLIHDELKLTDIEISTVDGFQGREKDVIILSLVRSNEKFEVGFLKEERRLNVAMTRPRRQLVVVGNIEVLQRCGNKYLKSWSEWCEENADVRYPNIDDYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
298PhosphorylationLDSNKRHSLDILSKK
CCCCCCCHHHHHHCC		31.6022369663
303PhosphorylationRHSLDILSKKNTIVK
CCHHHHHHCCCCHHH		41.7522369663
438AcetylationTIKTEDDKNVIHNLE
CCCCCCCCCHHHHHH		66.4924489116
469PhosphorylationVKFLNVQYRMNQKIM
HHHHCHHHHHCCHHH		13.9330377154
480PhosphorylationQKIMEFPSHSMYNGK
CHHHHCCCCCCCCCE		33.2530377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HCS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HCS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HCS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARD1_YEASTARD1genetic
17314980
SLX5_YEASTSLX5genetic
17314980
SLX8_YEASTSLX8genetic
17314980
PCNA_YEASTPOL30genetic
17314980
DOA1_YEASTDOA1genetic
19547744
NPL4_YEASTNPL4genetic
27708008
ATG12_YEASTATG12genetic
27708008
MGR1_YEASTMGR1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
ATG9_YEASTATG9genetic
27708008
MAF1_YEASTMAF1genetic
27708008
RAD55_YEASTRAD55genetic
27708008
METE_YEASTMET6genetic
27708008
MTHR2_YEASTMET13genetic
27708008
VMA21_YEASTVMA21genetic
27708008
RPN10_YEASTRPN10genetic
27708008
LPLA_YEASTAIM22genetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
UBR2_YEASTUBR2genetic
27708008
TSA1_YEASTTSA1genetic
27708008
GTR1_YEASTGTR1genetic
27708008
MSS1_YEASTMSS1genetic
27708008
IMP2_YEASTIMP2genetic
27708008
AEP2_YEASTAEP2genetic
27708008
SWC3_YEASTSWC3genetic
27708008
PMT2_YEASTPMT2genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
SWC5_YEASTSWC5genetic
27708008
REI1_YEASTREI1genetic
27708008
RV161_YEASTRVS161genetic
27708008
CWH43_YEASTCWH43genetic
27708008
FUB1_YEASTFUB1genetic
27708008
OST4_YEASTOST4genetic
27708008
AIM6_YEASTAIM6genetic
27708008
VMS1_YEASTVMS1genetic
27708008
YD210_YEASTYDR210Wgenetic
27708008
SWR1_YEASTSWR1genetic
27708008
SXM1_YEASTSXM1genetic
27708008
SDC1_YEASTSDC1genetic
27708008
SNF1_YEASTSNF1genetic
27708008
VPS72_YEASTVPS72genetic
27708008
IRC4_YEASTIRC4genetic
27708008
UBP6_YEASTUBP6genetic
27708008
DUG1_YEASTDUG1genetic
27708008
RL24A_YEASTRPL24Agenetic
27708008
VAM7_YEASTVAM7genetic
27708008
SAP4_YEASTSAP4genetic
27708008
RTF1_YEASTRTF1genetic
27708008
YG1D_YEASTYGR021Wgenetic
27708008
PEF1_YEASTPEF1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
SPO13_YEASTSPO13genetic
27708008
ICE2_YEASTICE2genetic
27708008
YIJ2_YEASTYIL092Wgenetic
27708008
YIW2_YEASTYIR042Cgenetic
27708008
VPS53_YEASTVPS53genetic
27708008
GPI7_YEASTLAS21genetic
27708008
GZF3_YEASTGZF3genetic
27708008
ILM1_YEASTILM1genetic
27708008
KKQ8_YEASTKKQ8genetic
27708008
POC2_YEASTADD66genetic
27708008
DOA1_YEASTDOA1genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ARP6_YEASTARP6genetic
27708008
ACE2_YEASTACE2genetic
27708008
ARV1_YEASTARV1genetic
27708008
VPS38_YEASTVPS38genetic
27708008
ECM19_YEASTECM19genetic
27708008
VPS71_YEASTVPS71genetic
27708008
IOC4_YEASTIOC4genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
RM44_YEASTMRPL44genetic
27708008
GAS1_YEASTGAS1genetic
27708008
PET8_YEASTPET8genetic
27708008
IPB2_YEASTPBI2genetic
27708008
BUD21_YEASTBUD21genetic
27708008
VAM3_YEASTVAM3genetic
27708008
CAF20_YEASTCAF20genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
HSP7F_YEASTSSE1genetic
27708008
BECN1_YEASTVPS30genetic
27708008
AIM44_YEASTAIM44genetic
27708008
HUT1_YEASTHUT1genetic
27708008
YME1_YEASTYME1genetic
27708008
CSR2_YEASTCSR2genetic
27708008
FCY1_YEASTFCY1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HCS1_YEAST

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Related Literatures of Post-Translational Modification

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