| UniProt ID | SDC1_YEAST | |
|---|---|---|
| UniProt AC | Q03323 | |
| Protein Name | COMPASS component SDC1 | |
| Gene Name | SDC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 175 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance.. | |
| Protein Sequence | MNESENSPQHNEVTVPMVEDTSSNADIPMEQIQREDNKNYDKHDNECFDMNGNHNNNSDNLQFDSVPSSATKDLKNIKSVTNQNVKIEESSSTNSVIEESSEPKISKLENVNLAATVGGSQTRKYLNTNVTPHLLAGMRLIAVQQPEDPLRVLGEYLIEQSNILKSGEKESNASK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MNESENSPQHN ----CCCCCCCCCCC | 36.75 | 28152593 | |
| 7 | Phosphorylation | -MNESENSPQHNEVT -CCCCCCCCCCCCCC | 23.14 | 24909858 | |
| 14 | Phosphorylation | SPQHNEVTVPMVEDT CCCCCCCCCEEEEEC | 16.83 | 19823750 | |
| 21 | Phosphorylation | TVPMVEDTSSNADIP CCEEEEECCCCCCCC | 22.13 | 19823750 | |
| 22 | Phosphorylation | VPMVEDTSSNADIPM CEEEEECCCCCCCCH | 33.64 | 19823750 | |
| 23 | Phosphorylation | PMVEDTSSNADIPME EEEEECCCCCCCCHH | 37.82 | 19823750 | |
| 79 | Phosphorylation | KDLKNIKSVTNQNVK HCHHHHHHHHCCCCE | 30.31 | 23749301 | |
| 90 | Phosphorylation | QNVKIEESSSTNSVI CCCEEECCCCCCCCE | 19.46 | 22369663 | |
| 91 | Phosphorylation | NVKIEESSSTNSVIE CCEEECCCCCCCCEE | 44.45 | 22369663 | |
| 92 | Phosphorylation | VKIEESSSTNSVIEE CEEECCCCCCCCEEC | 40.67 | 22369663 | |
| 93 | Phosphorylation | KIEESSSTNSVIEES EEECCCCCCCCEECC | 33.20 | 22369663 | |
| 95 | Phosphorylation | EESSSTNSVIEESSE ECCCCCCCCEECCCC | 25.26 | 22369663 | |
| 107 | Acetylation | SSEPKISKLENVNLA CCCCCCHHCCCCCEE | 64.39 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SDC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SDC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SDC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92 AND THR-93, AND MASSSPECTROMETRY. | |
