HOS4_YEAST - dbPTM
HOS4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HOS4_YEAST
UniProt AC P40480
Protein Name Protein HOS4
Gene Name HOS4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1083
Subcellular Localization
Protein Description Unknown. Component of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis..
Protein Sequence MNETTTKQPLKKRSLSSYLSNVSTRREELEKISKQETSEEEDTAGKHEQRETLSEEVSDKFPENVASFRSQTTSVHQATQNNLNAKESEDLAHKNDASSHEGEVNGDSRPDDVPETNEKISQAIRAKISSSSSSPNVRNVDIQNHQPFSRDQLRAMLKEPKRKTVDDFIEEEGLGAVEEEDLSDEVLEKNTTEPENVEKDIEYSDSDKDTDDVGSDDPTAPNSPIKLGRRKLVRGDQLDATTSSMFNNESDSELSDIDDSKNIALSSSLFRGGSSPVKETNNNLSNMNSSPAQNPKRGSVSRSNDSNKSSHIAVSKRPKQKKGIYRDSGGRTRLQIACDKGKYDVVKKMIEEGGYDINDQDNAGNTALHEAALQGHIEIVELLIENGADVNIKSIEMFGDTPLIDASANGHLDVVKYLLKNGADPTIRNAKGLTAFESVDDESEFDDEEDQKILREIKKRLSIAAKKWTNRAGIHNDKSKNGNNAHTIDQPPFDNTTKAKNEKAADSPSMASNIDEKAPEEEFYWTDVTSRAGKEKLFKASKEGHLPYVGTYVENGGKIDLRSFFESVKCGHEDITSIFLAFGFPVNQTSRDNKTSALMVAVGRGHLGTVKLLLEAGADPTKRDKKGRTALYYAKNSIMGITNSEEIQLIENAINNYLKKHSEDNNDDDDDDDNNNETYKHEKKREKTQSPILASRRSATPRIEDEEDDTRMLNLADDDFNNDRDVKESTTSDSRKRLDDNENVGTQYSLDWKKRKTNALQDEEKLKSISPLSMEPHSPKKAKSVEISKIHEETAAEREARLKEEEEYRKKRLEKKRKKEQELLQKLAEDEKKRIEEQEKQKVLEMERLEKATLEKARKMEREKEMEEISYRRAVRDLYPLGLKIINFNDKLDYKRFLPLYYFVDEKNDKFVLDLQVMILLKDIDLLSKDNQPTSEKIPVDPSHLTPLWNMLKFIFLYGGSYDDKKNNMENKRYVVNFDGVDLDTKIGYELLEYKKFVSLPMAWIKWDNVVIENHAKRKEIEGNMIQISINEFARWRNDKLNKAQQPTRKQRSLKIPRELPVKFQHRMSISSVLQQTSKEPFW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationKQPLKKRSLSSYLSN
CCCCCHHCHHHHHHC		41.2925752575
16PhosphorylationPLKKRSLSSYLSNVS
CCCHHCHHHHHHCHH		20.4123749301
17PhosphorylationLKKRSLSSYLSNVST
CCHHCHHHHHHCHHH		35.0728889911
20PhosphorylationRSLSSYLSNVSTRRE
HCHHHHHHCHHHHHH		27.2728889911
23PhosphorylationSSYLSNVSTRREELE
HHHHHCHHHHHHHHH		22.0528889911
24PhosphorylationSYLSNVSTRREELEK
HHHHCHHHHHHHHHH		29.4828889911
31AcetylationTRREELEKISKQETS
HHHHHHHHHHHCCCC		65.9725381059
33PhosphorylationREELEKISKQETSEE
HHHHHHHHHCCCCHH		39.0822369663
37PhosphorylationEKISKQETSEEEDTA
HHHHHCCCCHHHCCC		38.6622369663
38PhosphorylationKISKQETSEEEDTAG
HHHHCCCCHHHCCCC		42.1122369663
43PhosphorylationETSEEEDTAGKHEQR
CCCHHHCCCCHHHHH		40.3622369663
52PhosphorylationGKHEQRETLSEEVSD
CHHHHHHHHCHHHHH		37.4622369663
54PhosphorylationHEQRETLSEEVSDKF
HHHHHHHCHHHHHHC		38.8522369663
58PhosphorylationETLSEEVSDKFPENV
HHHCHHHHHHCCHHH		38.0622369663
67PhosphorylationKFPENVASFRSQTTS
HCCHHHHHHHHHCCC		19.5328889911
70PhosphorylationENVASFRSQTTSVHQ
HHHHHHHHHCCCHHH		29.8427017623
73PhosphorylationASFRSQTTSVHQATQ
HHHHHHCCCHHHHHH		22.5530377154
74PhosphorylationSFRSQTTSVHQATQN
HHHHHCCCHHHHHHH		22.4623749301
88PhosphorylationNNLNAKESEDLAHKN
HCCCHHHHHHHCCCC		35.3921440633
98PhosphorylationLAHKNDASSHEGEVN
HCCCCCCCCCCCCCC		34.7821551504
99PhosphorylationAHKNDASSHEGEVNG
CCCCCCCCCCCCCCC		27.5521440633
129PhosphorylationQAIRAKISSSSSSPN
HHHHHHHHCCCCCCC		24.3828889911
130PhosphorylationAIRAKISSSSSSPNV
HHHHHHHCCCCCCCC		37.4022369663
131PhosphorylationIRAKISSSSSSPNVR
HHHHHHCCCCCCCCC		27.7024961812
132PhosphorylationRAKISSSSSSPNVRN
HHHHHCCCCCCCCCC		36.4622369663
133PhosphorylationAKISSSSSSPNVRNV
HHHHCCCCCCCCCCC		52.3322369663
134PhosphorylationKISSSSSSPNVRNVD
HHHCCCCCCCCCCCC		23.5722369663
183PhosphorylationAVEEEDLSDEVLEKN
CCCHHHCCHHHHHCC		44.0128889911
191PhosphorylationDEVLEKNTTEPENVE
HHHHHCCCCCCHHHH		43.5322890988
192PhosphorylationEVLEKNTTEPENVEK
HHHHCCCCCCHHHHH		59.9625521595
203PhosphorylationNVEKDIEYSDSDKDT
HHHHHHCCCCCCCCC		20.3619795423
204PhosphorylationVEKDIEYSDSDKDTD
HHHHHCCCCCCCCCC		20.1820377248
206PhosphorylationKDIEYSDSDKDTDDV
HHHCCCCCCCCCCCC		40.3920377248
210PhosphorylationYSDSDKDTDDVGSDD
CCCCCCCCCCCCCCC		39.5820377248
215PhosphorylationKDTDDVGSDDPTAPN
CCCCCCCCCCCCCCC		38.3920377248
219PhosphorylationDVGSDDPTAPNSPIK
CCCCCCCCCCCCCCC		62.8419795423
223PhosphorylationDDPTAPNSPIKLGRR
CCCCCCCCCCCCCCC		27.2621551504
244PhosphorylationQLDATTSSMFNNESD
CCCHHHHHHCCCCCC		25.8719779198
250PhosphorylationSSMFNNESDSELSDI
HHHCCCCCCCCCCCC		48.8621440633
252PhosphorylationMFNNESDSELSDIDD
HCCCCCCCCCCCCCC		50.1121440633
255PhosphorylationNESDSELSDIDDSKN
CCCCCCCCCCCCCCC		28.5921440633
260PhosphorylationELSDIDDSKNIALSS
CCCCCCCCCCEECCC		24.6919779198
266PhosphorylationDSKNIALSSSLFRGG
CCCCEECCCCCCCCC		14.6222369663
267PhosphorylationSKNIALSSSLFRGGS
CCCEECCCCCCCCCC		31.7322369663
268PhosphorylationKNIALSSSLFRGGSS
CCEECCCCCCCCCCC		28.3122369663
274PhosphorylationSSLFRGGSSPVKETN
CCCCCCCCCCCCCCC		34.0019823750
275PhosphorylationSLFRGGSSPVKETNN
CCCCCCCCCCCCCCC		36.6725521595
280PhosphorylationGSSPVKETNNNLSNM
CCCCCCCCCCCCCCC		37.2122369663
285PhosphorylationKETNNNLSNMNSSPA
CCCCCCCCCCCCCCC		35.8419779198
289PhosphorylationNNLSNMNSSPAQNPK
CCCCCCCCCCCCCCC		27.2522369663
290PhosphorylationNLSNMNSSPAQNPKR
CCCCCCCCCCCCCCC		21.1722369663
299PhosphorylationAQNPKRGSVSRSNDS
CCCCCCCCCCCCCCC		22.4327717283
301PhosphorylationNPKRGSVSRSNDSNK
CCCCCCCCCCCCCCC		31.5227717283
309PhosphorylationRSNDSNKSSHIAVSK
CCCCCCCCCCEEEEC		31.2523749301
443PhosphorylationFESVDDESEFDDEED
EECCCCCCCCCHHHH		51.0328152593
507PhosphorylationKNEKAADSPSMASNI
CCHHHCCCCHHHCCC		17.7222369663
509PhosphorylationEKAADSPSMASNIDE
HHHCCCCHHHCCCCC		30.8219779198
512PhosphorylationADSPSMASNIDEKAP
CCCCHHHCCCCCCCC		26.1929136822
688PhosphorylationHEKKREKTQSPILAS
HHHHHHHCCCCHHHC		29.5322369663
690PhosphorylationKKREKTQSPILASRR
HHHHHCCCCHHHCCC		21.0922369663
695PhosphorylationTQSPILASRRSATPR
CCCCHHHCCCCCCCC		25.4422369663
698PhosphorylationPILASRRSATPRIED
CHHHCCCCCCCCCCC		35.0717330950
700PhosphorylationLASRRSATPRIEDEE
HHCCCCCCCCCCCCC		17.8521551504
768PhosphorylationQDEEKLKSISPLSME
CCHHHHHCCCCCCCC		38.4421440633
770PhosphorylationEEKLKSISPLSMEPH
HHHHHCCCCCCCCCC		27.2121440633
773PhosphorylationLKSISPLSMEPHSPK
HHCCCCCCCCCCCCC		25.2021440633
778PhosphorylationPLSMEPHSPKKAKSV
CCCCCCCCCCCCCCE		49.4817330950
784PhosphorylationHSPKKAKSVEISKIH
CCCCCCCCEEHHHHC		29.8223749301
789AcetylationAKSVEISKIHEETAA
CCCEEHHHHCHHHHH		54.4625381059
870PhosphorylationEKEMEEISYRRAVRD
HHHHHHHHHHHHHHH		18.8328889911
935PhosphorylationSKDNQPTSEKIPVDP
CCCCCCCCCCCCCCH		43.5028889911
1069PhosphorylationVKFQHRMSISSVLQQ
CCHHHCCCHHHHHHH		21.1928889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HOS4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HOS4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HOS4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HOS2_YEASTHOS2physical
11711434
HST1_YEASTHST1physical
11711434
SET3_YEASTSET3physical
11711434
SIF2_YEASTSIF2physical
11711434
SNT1_YEASTSNT1physical
11711434
CYPH_YEASTCPR1physical
11711434
SNT1_YEASTSNT1physical
15643056
HST1_YEASTHST1physical
15643056
SET3_YEASTSET3physical
16554755
HOS2_YEASTHOS2physical
16429126
SIF2_YEASTSIF2physical
16429126
ACT_YEASTACT1genetic
17314980
APQ12_YEASTAPQ12genetic
17314980
RPB3_YEASTRPB3genetic
17314980
ELP5_YEASTIKI1genetic
17314980
RPN2_YEASTRPN2genetic
17314980
ARO1_YEASTARO1genetic
17314980
PAT1_YEASTPAT1genetic
17314980
GCN1_YEASTGCN1genetic
17314980
H3_YEASTHHT1genetic
18676811
SSB1_YEASTSSB1physical
19536198
HDA2_YEASTHDA2genetic
21288874
PALF_YEASTRIM8genetic
27708008
OSH3_YEASTOSH3genetic
27708008
EI2BA_YEASTGCN3genetic
27708008
STE50_YEASTSTE50genetic
27708008
RPN4_YEASTRPN4genetic
27708008
QRI7_YEASTQRI7genetic
27708008
RAD57_YEASTRAD57genetic
27708008
OS9_YEASTYOS9genetic
27708008
UBC13_YEASTUBC13genetic
27708008
SWR1_YEASTSWR1genetic
27708008
PAL1_YEASTPAL1genetic
27708008
DOT1_YEASTDOT1genetic
27708008
VTC2_YEASTVTC2genetic
27708008
BUD27_YEASTBUD27genetic
27708008
CGR1_YEASTCGR1genetic
27708008
CUE3_YEASTCUE3genetic
27708008
AAKG_YEASTSNF4genetic
27708008
TIM13_YEASTTIM13genetic
27708008
AP3B_YEASTAPL6genetic
27708008
ICS3_YEASTICS3genetic
27708008
RPE_YEASTRPE1genetic
27708008
SWE1_YEASTSWE1genetic
27708008
MOG1_YEASTMOG1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
BRE2_YEASTBRE2genetic
27708008
CDC73_YEASTCDC73genetic
27708008
RL36A_YEASTRPL36Agenetic
27708008
SCS7_YEASTSCS7genetic
27708008
YM94_YEASTYMR315Wgenetic
27708008
EF3B_YEASTHEF3genetic
27708008
PHO23_YEASTPHO23genetic
27708008
EAF7_YEASTEAF7genetic
27708008
SIN3_YEASTSIN3genetic
27708008
SERC_YEASTSER1genetic
27708008
CHL1_YEASTCHL1genetic
27708008
YP014_YEASTYPL014Wgenetic
27708008
CTI6_YEASTCTI6genetic
27708008
YP260_YEASTYPL260Wgenetic
27708008
PPAL_YEASTLTP1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HOS4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-17; SER-67;SER-134; SER-183; THR-192; SER-507; SER-690; SER-698; THR-700 ANDSER-778, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38; SER-54; SER-274;THR-688; SER-690 AND THR-700, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, AND MASSSPECTROMETRY.

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