| UniProt ID | OS9_YEAST | |
|---|---|---|
| UniProt AC | Q99220 | |
| Protein Name | Protein OS-9 homolog | |
| Gene Name | YOS9 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 542 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Peripheral membrane protein Lumenal side . |
|
| Protein Description | Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. The recognition of targets is N-glycan specific.. | |
| Protein Sequence | MQAKIIYALSAISALIPLGSSLLAPIEDPIVSNKYLISYIDEDDWSDRILQNQSVMNSGYIVNMGDDLECFIQNASTQLNDVLEDSNEHSNSEKTALLTKTLNQGVKTIFDKLNERCIFYQAGFWIYEYCPGIEFVQFHGRVNTKTGEIVNRDESLVYRLGKPKANVEEREFELLYDDVGYYISEIIGSGDICDVTGAERMVEIQYVCGGSNSGPSTIQWVRETKICVYEAQVTIPELCNLELLAKNEDQKNASPILCRMPAKSKIGSNSIDLITKYEPIFLGSGIYFLRPFNTDERDKLMVTDNAMSNWDEITETYYQKFGNAINKMLSLRLVSLPNGHILQPGDSCVWLAEVVDMKDRFQTTLSLNILNSQRAEIFFNKTFTFNEDNGNFLSYKIGDHGESTELGQITHSNKADINTAEIRSDEYLINTDNELFLRISKEIAEVKELLNEIVSPHEMEVIFENMRNQPNNDFELALMNKLKSSLNDDNKVEQINNARMDDDESTSHTTRDIGEAGSQTTGNTESEVTNVAAGVFIEHDEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | Phosphorylation | DPIVSNKYLISYIDE CCCCCCCEEEEEECC | 17.33 | 25005228 | |
| 46 | Phosphorylation | YIDEDDWSDRILQNQ EECCCCCCCHHHHCC | 24.81 | 25005228 | |
| 52 | N-linked_Glycosylation | WSDRILQNQSVMNSG CCCHHHHCCCCCCCC | 32.42 | - | |
| 74 | N-linked_Glycosylation | DLECFIQNASTQLND CHHHHHHCHHHHHHH | 30.92 | - | |
| 112 | Acetylation | GVKTIFDKLNERCIF HHHHHHHHHHHHEEH | 42.32 | 24489116 | |
| 145 | Ubiquitination | FHGRVNTKTGEIVNR EECEECCCCCCEECC | 49.70 | 24961812 | |
| 308 | Phosphorylation | MVTDNAMSNWDEITE EECCCCCCCHHHHHH | 32.15 | 27017623 | |
| 316 | Phosphorylation | NWDEITETYYQKFGN CHHHHHHHHHHHHHH | 20.91 | 27017623 | |
| 317 | Phosphorylation | WDEITETYYQKFGNA HHHHHHHHHHHHHHH | 9.54 | 27017623 | |
| 380 | N-linked_Glycosylation | QRAEIFFNKTFTFNE CCEEEEEECEEEECC | 31.54 | - | |
| 505 | Phosphorylation | ARMDDDESTSHTTRD CCCCCCCCCCCCCCC | 42.05 | 28889911 | |
| 506 | Phosphorylation | RMDDDESTSHTTRDI CCCCCCCCCCCCCCH | 23.60 | 28889911 | |
| 507 | Phosphorylation | MDDDESTSHTTRDIG CCCCCCCCCCCCCHH | 28.28 | 28889911 | |
| 509 | Phosphorylation | DDESTSHTTRDIGEA CCCCCCCCCCCHHHH | 24.24 | 28889911 | |
| 510 | Phosphorylation | DESTSHTTRDIGEAG CCCCCCCCCCHHHHC | 22.41 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OS9_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OS9_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OS9_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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