| UniProt ID | TRS85_YEAST | |
|---|---|---|
| UniProt AC | P46944 | |
| Protein Name | Trafficking protein particle complex III-specific subunit 85 | |
| Gene Name | TRS85 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 698 | |
| Subcellular Localization | Preautophagosomal structure . | |
| Protein Description | Specific subunit of the TRAPP III complex that acts as an autophagy-specific guanine nucleotide exchange factor (GEF) for YPT1. TRS85 directs the TRAPP III complex to the phagophore assembly site (PAS) that is involved in autophagosome formation. Required for membrane expansion during autophagy and the CVT pathway. Required for sporulation. Has a role late in meiosis following DNA replication.. | |
| Protein Sequence | MVFSYEHYMNLLFHLDNSKETVPPEIAKRIISNAIAPVITVTSTPLFDKHIQETYKVDSLYMLLRFFGGCVSDRDQANEAKVGQHEHEVCDASDSTDSIPKNKNLEVPNLSKKGSRSRSNSLFQRDSTQSQYIRFTRPLGDLIETRDANDMLFNYHSLEVFLDNYLKLVAANTDEMVPHNLLKKSIYHSFFSLAISSTNNLSPYETFNHPILSLIALDISNGEVYEDARDLLVNFKNLNHNTENFPIFMNTNEMLPVFLLCYNDDSQEEFEKCQALAKKLKKQLFVESILLALWKDSFIYDENSVIQLHQPVMSSLEEILFFLQAPTQTTLSLALINSIYDMLDYLVYDLMIPFMKRKVSFWEETILQPRKSLFNGAKFFKKFMNKNPVNGNHQHNSLTRDSQGNEYFASSSSEFLMRKLADWSMMLSDFKTAYSTYESLMDDLDAFPKYLASCIEWCAVSLLMGAQSIVTVKMIKNDINPLIERALATYENCSRIQRGKGKESNSLDVTEPVRSYETRCMILASELFLSLSNTWTSTPYAIQYLETILDECKLGPCSQIMVWERLSDCYNLRVDPRIKHRVGAMKKDAKDTEDLRGEHKYSTDHFTDEDILSEGLTRRRKAAFFRLIAAKKWAEQKQWRQVSWCLKDIESTYSEIKFLHGNGLILSKLKNQLNLKDVDSAPRPSEKNLTRTSVSFIG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MVFSYEHYMNL ----CCCCHHHHHHH | 20.43 | 24961812 | |
| 5 | Phosphorylation | ---MVFSYEHYMNLL ---CCCCHHHHHHHH | 8.68 | 24961812 | |
| 8 | Phosphorylation | MVFSYEHYMNLLFHL CCCCHHHHHHHHHHC | 3.93 | 28889911 | |
| 18 | Phosphorylation | LLFHLDNSKETVPPE HHHHCCCCCCCCCHH | 31.38 | 30377154 | |
| 93 | Phosphorylation | EHEVCDASDSTDSIP CCCCCCCCCCCCCCC | 20.88 | 29136822 | |
| 95 | Phosphorylation | EVCDASDSTDSIPKN CCCCCCCCCCCCCCC | 31.45 | 20377248 | |
| 96 | Phosphorylation | VCDASDSTDSIPKNK CCCCCCCCCCCCCCC | 38.46 | 29136822 | |
| 98 | Phosphorylation | DASDSTDSIPKNKNL CCCCCCCCCCCCCCC | 40.66 | 19823750 | |
| 111 | Phosphorylation | NLEVPNLSKKGSRSR CCCCCCCCCCCCCCC | 38.67 | 24961812 | |
| 117 | Phosphorylation | LSKKGSRSRSNSLFQ CCCCCCCCCCCCCCC | 41.58 | 22369663 | |
| 119 | Phosphorylation | KKGSRSRSNSLFQRD CCCCCCCCCCCCCCC | 31.83 | 22369663 | |
| 121 | Phosphorylation | GSRSRSNSLFQRDST CCCCCCCCCCCCCCC | 31.63 | 22369663 | |
| 145 | Phosphorylation | PLGDLIETRDANDML CHHHHHCCCCCCCCC | 27.19 | 27017623 | |
| 500 | Ubiquitination | CSRIQRGKGKESNSL CHHHHCCCCCCCCCC | 69.83 | 22817900 | |
| 502 | Ubiquitination | RIQRGKGKESNSLDV HHHCCCCCCCCCCCC | 62.55 | 23749301 | |
| 506 | Phosphorylation | GKGKESNSLDVTEPV CCCCCCCCCCCCCCC | 34.91 | 28889911 | |
| 685 | Phosphorylation | VDSAPRPSEKNLTRT CCCCCCCCCCCCCCC | 63.58 | 23749301 | |
| 687 | Ubiquitination | SAPRPSEKNLTRTSV CCCCCCCCCCCCCEE | 62.69 | 23749301 | |
| 690 | Phosphorylation | RPSEKNLTRTSVSFI CCCCCCCCCCEECCC | 41.09 | 23749301 | |
| 692 | Phosphorylation | SEKNLTRTSVSFIG- CCCCCCCCEECCCC- | 28.39 | 19795423 | |
| 693 | Phosphorylation | EKNLTRTSVSFIG-- CCCCCCCEECCCC-- | 16.69 | 21440633 | |
| 695 | Phosphorylation | NLTRTSVSFIG---- CCCCCEECCCC---- | 15.77 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRS85_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRS85_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRS85_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121, AND MASSSPECTROMETRY. | |
