SCP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCP1_YEAST
• UniProt AC: Q08873
• Protein Name: Transgelin
• Gene Name: SCP1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 200
• Subcellular Localization: Cytoplasm, cytoskeleton, actin patch . Cortical actin patches.
• Protein Description: Has actin-binding and actin-bundling activity. Stabilizes actin filaments against disassembly..
• Protein Sequence: MSYDKKADVTSLDEDLRQLRESKFSPEAIQNIKIWVYKSVLKEIAPPGDLLECLKDGTVLCKLANILYEADTGEANHISWKSSKMPFVQMDQISQFLSFSRKYGVPEDELFQTIDLFEKKDPAIVFQTLKSLSRYANKKHTDRFPVLGPQLSTKKPRPPVKSKPKHLQDGTGWSTFEYGYMKGASQATEGVVLGQRRDIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSYDKKADV ------CCCCCCCCC	41.88	22814378
10	Phosphorylation	YDKKADVTSLDEDLR CCCCCCCCCCCHHHH	24.91	22369663
11	Phosphorylation	DKKADVTSLDEDLRQ CCCCCCCCCCHHHHH	33.40	22369663
23	Acetylation	LRQLRESKFSPEAIQ HHHHHHCCCCHHHHH	45.14	24489116
38	Acetylation	NIKIWVYKSVLKEIA HCCEEEHHHHHHHHC	25.19	24489116
154	Acetylation	LGPQLSTKKPRPPVK CCCCCCCCCCCCCCC	58.36	25381059
188	Phosphorylation	MKGASQATEGVVLGQ CCCCCCCCCCEECCC	26.15	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCP1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABP1_YEAST	ABP1	physical	14737190
ACT_YEAST	ACT1	physical	12868959
FIMB_YEAST	SAC6	genetic	12857851
FIMB_YEAST	SAC6	genetic	12868959
ACT_YEAST	ACT1	physical	18400761
FIMB_YEAST	SAC6	genetic	18400761
TOR2_YEAST	TOR2	genetic	20526336
ROM1_YEAST	ROM1	genetic	22065638
DPOD_YEAST	POL3	genetic	27708008
RPB1_YEAST	RPO21	genetic	27708008
RSP5_YEAST	RSP5	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
DPOD2_YEAST	POL31	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10 AND SER-11, AND MASSSPECTROMETRY.
PubMed: 18407956

"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, AND MASSSPECTROMETRY.
PubMed: 17287358

"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, AND MASSSPECTROMETRY.
PubMed: 17330950