NNF2_YEAST - dbPTM
NNF2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NNF2_YEAST
UniProt AC P53253
Protein Name Protein NNF2
Gene Name NNF2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 936
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MEEQFTNQKKVSHLQSLMNTKRSEQPTEFAKKHRFKDTLALFLVFLSFNHFTSLCLLVSFIVATKCKDFLANCFIILFLSKKPSRHIGEVAHIDISTSKVTNGSSNRKSNSRFFGNSKNSFVIPIPVLICEILFAMLLKIYGGDYFVKPIKNLAISIIASFLINDPSDCLSYATSCSVLYAVSTNTFQRVSHFFDIIQLFDMSLRGTGQSIKLFTVFRKYSQFFKKLFSLFLPMPFKMLGKHSDSMIYYLSFHILFFSFASSLLHPHRQTAENKPLKKGFNSTKPDVARVQGLQKMRISSSSSVSADSNTLEDQSPMIPNDPGGLSSSNQTIHPSQQNNSPVPLSSHSNILNPAASYPTDATSSFPYFTSMVKEYKSYQPSVISAEGSNSQAVTTTTSTTTSPTTFNFSGDNTSLSNEISLSDSSNGNSKKDSDFFSPSNDKYTNQLFELNVDFGNMFSSSKLSSDISVTSNLENFIRLLFRRKNQHLIAPLWSMVVTLKTTNFEKKYLQETSENSLTPTNSNTSYVSNQEKHDKDLDTINTHSVSSRISFTHAGKFKKSVFNNFEPSNTMALIAKTTSDDYNLLNLVSTNENIFNRNDNDYKVCIIDISTNSITFHIENLHDGELIVLVNGVIWSEVSCALILEHVGEEYVVVNGLVPSCSYDIQFINRLNHRDDYLVSDLIVRTCGNNNAIAGKFENLDFSFPSYYHRKFLSPLLTLKHSVLTTNANLSDERTKLKKTKKEFSKKLSLLRQEIDYFKGRISQNATHDEKSTLKVENLKVALQQSETAVNKLEMQLKTLTEKELELEEEYLKKKDLHLKNQLEFSKLEESLSKDLKNSEGRFQKVNQELVQLGSKLDKLNARNEKLQKEVDQNAEEIEKFSTQFLSKREKDRFRRKEYRIREANKFELTIKGLEQDINRLENENENIHSLIGNSY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10UbiquitinationEQFTNQKKVSHLQSL
HHHCCHHHHHHHHHH		38.9212872131
283PhosphorylationLKKGFNSTKPDVARV
CCCCCCCCCCCHHHH		47.9321440633
364PhosphorylationYPTDATSSFPYFTSM
CCCCCCCCCHHHHHH		26.3627017623
508PhosphorylationTTNFEKKYLQETSEN
CCCHHHHHHHHCCCC		25.3722369663
512PhosphorylationEKKYLQETSENSLTP
HHHHHHHCCCCCCCC		28.5122369663
513PhosphorylationKKYLQETSENSLTPT
HHHHHHCCCCCCCCC		33.7522369663
516PhosphorylationLQETSENSLTPTNSN
HHHCCCCCCCCCCCC		29.5722369663
518PhosphorylationETSENSLTPTNSNTS
HCCCCCCCCCCCCCC		28.0822369663
520PhosphorylationSENSLTPTNSNTSYV
CCCCCCCCCCCCCCC		46.1520377248
522PhosphorylationNSLTPTNSNTSYVSN
CCCCCCCCCCCCCCC		43.9222369663
524PhosphorylationLTPTNSNTSYVSNQE
CCCCCCCCCCCCCCH		22.6622369663
525PhosphorylationTPTNSNTSYVSNQEK
CCCCCCCCCCCCCHH		27.9920377248
526PhosphorylationPTNSNTSYVSNQEKH
CCCCCCCCCCCCHHC		13.0822369663
528PhosphorylationNSNTSYVSNQEKHDK
CCCCCCCCCCHHCCC		25.2722369663
542PhosphorylationKDLDTINTHSVSSRI
CCCCCCCCCCHHHCE		16.2119779198
550PhosphorylationHSVSSRISFTHAGKF
CCHHHCEEEEECCCC		24.0027017623
577PhosphorylationTMALIAKTTSDDYNL
CEEEEEEECCCCCCH		23.6230377154
714PhosphorylationYYHRKFLSPLLTLKH
HHHHHCHHHHHHHHC		19.3421440633
771AcetylationQNATHDEKSTLKVEN
CCCCCCCCCCEEEEH		55.5924489116
935PhosphorylationIHSLIGNSY------
HHHHHCCCC------		27.3221440633
936PhosphorylationHSLIGNSY-------
HHHHCCCC-------		26.9421440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NNF2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NNF2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NNF2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SMC1_YEASTSMC1physical
11087867
YEF3_YEASTYEL043Wphysical
11087867
NNF2_YEASTNNF2physical
11087867
PFD4_YEASTGIM3physical
11087867
KAR3_YEASTKAR3physical
11087867
GET2_YEASTGET2genetic
16269340
GOSR1_YEASTGOS1genetic
16269340
SEC22_YEASTSEC22genetic
16269340
SCS7_YEASTSCS7genetic
16269340
COPB2_YEASTSEC27genetic
16269340
RGP1_YEASTRGP1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
GET1_YEASTGET1genetic
16269340
ATC3_YEASTDRS2genetic
16269340
VPS21_YEASTVPS21genetic
16269340
TRS20_YEASTTRS20genetic
16269340
SSH1_YEASTSSH1genetic
16269340
ORM2_YEASTORM2genetic
16269340
COPE_YEASTSEC28genetic
16269340
TMEDA_YEASTERV25genetic
16269340
ORM1_YEASTORM1genetic
16269340
GDA1_YEASTGDA1genetic
16269340
COG2_YEASTCOG2genetic
16269340
GET3_YEASTGET3genetic
16269340
ERG4_YEASTERG4genetic
16269340
SWA2_YEASTSWA2genetic
16269340
PER1_YEASTPER1genetic
16269340
BST1_YEASTBST1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
GAS1_YEASTGAS1genetic
16269340
GLO3_YEASTGLO3genetic
21127252
RPN4_YEASTRPN4genetic
21127252
KCS1_YEASTKCS1genetic
21127252
PP2A2_YEASTPPH22genetic
21127252
RTG3_YEASTRTG3genetic
21127252
SUM1_YEASTSUM1genetic
21127252
DCC1_YEASTDCC1genetic
21127252
SWC3_YEASTSWC3physical
22875988
KIN3_YEASTKIN3physical
22875988
EXO84_YEASTEXO84physical
22875988
YET3_YEASTYET3physical
22875988
SIR4_YEASTSIR4physical
22875988
IVY1_YEASTIVY1physical
22875988
SNX41_YEASTSNX41physical
22875988
VAM7_YEASTVAM7physical
22875988
NNF2_YEASTNNF2physical
22875988
LNP_YEASTLNP1physical
22875988
NOT3_YEASTNOT3physical
22875988
MPS3_YEASTMPS3physical
22875988
NUP82_YEASTNUP82physical
22875988
SA185_YEASTSAP185physical
22875988
BLI1_YEASTBLI1physical
22875988
HSK3_YEASTHSK3physical
22875988
DYHC_YEASTDYN1physical
22875988
DAD2_YEASTDAD2physical
22875988
SED5_YEASTSED5physical
22875988
SEC10_YEASTSEC10physical
22875988
NKP2_YEASTNKP2physical
22875988
FMP27_YEASTFMP27physical
22875988
RCF1_YEASTRCF1physical
22875988
MDM1_YEASTMDM1physical
22875988
PDS5_YEASTPDS5physical
22875988
VPS20_YEASTVPS20physical
22875988
SPC24_YEASTSPC24physical
22875988
CBF3B_YEASTCEP3physical
22875988
END3_YEASTEND3physical
22875988
AF9_YEASTYAF9physical
22875988
RPAC2_YEASTRPC19physical
22875988
PFD4_YEASTGIM3physical
22875988
NUF2_YEASTNUF2physical
22875988
VPS5_YEASTVPS5physical
22875988
PRS6A_YEASTRPT5physical
22875988
HPH1_YEASTFRT1physical
22875988
SCD5_YEASTSCD5physical
22875988
LGE1_YEASTLGE1physical
22875988
TBP6_YEASTYTA6physical
22875988
GYP5_YEASTGYP5physical
22875988
NCA2_YEASTNCA2physical
22875988
SHE9_YEASTSHE9physical
22875988
KEL2_YEASTKEL2physical
22875988
YJE9_YEASTYJL049Wphysical
22875988
SET2_YEASTSET2physical
22875988
SRN2_YEASTSRN2physical
22875988
YP174_YEASTYPR174Cphysical
22875988
SWI5_YEASTSWI5physical
22875988
SPC25_YEASTSPC25physical
22875988
ETP1_YEASTETP1physical
22875988
MPC70_YEASTSPO21physical
22875988
TUP1_YEASTTUP1physical
22875988
NUM1_YEASTNUM1physical
22875988
LAM4_YEASTYHR080Cphysical
22875988
NDE1_YEASTNDL1physical
22875988
VPS1_YEASTVPS1genetic
23891562
VPS8_YEASTVPS8genetic
23891562
VPS17_YEASTVPS17genetic
23891562
VPS21_YEASTVPS21genetic
23891562
SRO7_YEASTSRO7genetic
23891562
PACC_YEASTRIM101genetic
23891562
HACD_YEASTPHS1genetic
23891562
CSG2_YEASTCSG2genetic
23891562
THIL_YEASTERG10genetic
23891562
TPM1_YEASTTPM1genetic
23891562
THRC_YEASTTHR4genetic
27708008
BEM2_YEASTBEM2genetic
27708008
ATC3_YEASTDRS2genetic
27708008
CSG2_YEASTCSG2genetic
27708008
RU1A_YEASTMUD1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
RPN4_YEASTRPN4genetic
27708008
GPR1_YEASTGPR1genetic
27708008
UBX3_YEASTUBX3genetic
27708008
CYK3_YEASTCYK3genetic
27708008
TRS85_YEASTTRS85genetic
27708008
SWF1_YEASTSWF1genetic
27708008
RGA2_YEASTRGA2genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
RV167_YEASTRVS167genetic
27708008
GET2_YEASTGET2genetic
27708008
SWI4_YEASTSWI4genetic
27708008
SLX8_YEASTSLX8genetic
27708008
KC13_YEASTYCK3genetic
27708008
UBP3_YEASTUBP3genetic
27708008
PHO4_YEASTPHO4genetic
27708008
HNM1_YEASTHNM1genetic
27708008
MMS2_YEASTMMS2genetic
27708008
MRM2_YEASTMRM2genetic
27708008
AIM14_YEASTAIM14genetic
27708008
VAM7_YEASTVAM7genetic
27708008
HXKB_YEASTHXK2genetic
27708008
FZF1_YEASTFZF1genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
DSE2_YEASTDSE2genetic
27708008
ACA2_YEASTCST6genetic
27708008
ASG1_YEASTASG1genetic
27708008
SYS1_YEASTSYS1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
RPE_YEASTRPE1genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
SET2_YEASTSET2genetic
27708008
RCY1_YEASTRCY1genetic
27708008
PGM1_YEASTPGM1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
DNM1_YEASTDNM1genetic
27708008
ENV10_YEASTENV10genetic
27708008
MMR1_YEASTMMR1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
YPT6_YEASTYPT6genetic
27708008
SEC22_YEASTSEC22genetic
27708008
VAC14_YEASTVAC14genetic
27708008
SST2_YEASTSST2genetic
27708008
COG8_YEASTCOG8genetic
27708008
PKR1_YEASTPKR1genetic
27708008
RAD14_YEASTRAD14genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
SCS7_YEASTSCS7genetic
27708008
TDA1_YEASTTDA1genetic
27708008
COG6_YEASTCOG6genetic
27708008
TPM1_YEASTTPM1genetic
27708008
FAR11_YEASTFAR11genetic
27708008
BRE5_YEASTBRE5genetic
27708008
PHO80_YEASTPHO80genetic
27708008
VPS21_YEASTVPS21genetic
27708008
VPH1_YEASTVPH1genetic
27708008
ARL3_YEASTARL3genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
ELP3_YEASTELP3genetic
27708008
NEW1_YEASTNEW1genetic
27708008
FUMH_YEASTFUM1genetic
27708008
MDL2_YEASTMDL2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NNF2_YEAST

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-10, AND MASSSPECTROMETRY.

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