RGA2_YEAST - dbPTM
RGA2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGA2_YEAST
UniProt AC Q06407
Protein Name Rho-type GTPase-activating protein 2
Gene Name RGA2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1009
Subcellular Localization
Protein Description GTPase-activating protein (GAP) for CDC42 and/or RHO1..
Protein Sequence MSADPINDQSSLCVRCNKSIASSQVYELESKKWHDQCFTCYKCDKKLNADSDFLVLDIGTLICYDCSDKCTNCGDKIDDTAIILPSSNEAYCSNCFRCCRCSNRIKNLKYAKTKRGLCCMDCHEKLLRKKQLLLENQTKNSSKEDFPIKLPERSVKRPLSPTRINGKSDVSTNNTAISKNLVSSNEDQQLTPQVLVSQERDESSLNDNNDNDNSKDREETSSHARTVSIDDILNSTLEHDSNSIEEQSLVDNEDYINKMGEDVTYRLLKPQRANRDSIVVKDPRIPNSNSNANRFFSIYDKEETDKDDTDNKENEIIVNTPRNSTDKITSPLNSPMAVQMNEEVEPPHGLALTLSEATKENNKSSQGIQTSTSKSMNHVSPITRTDTVEMKTSTSSSTLRLSDNGSFSRPQTADNLLPHKKVAPSPNKKLSRSFSLKSKNFVHNLKSKTSEMLDPKHPHHSTSIQESDTHSGWGVSSTHTNIRKSKAKKNPVSRGQSDSTIYNTLPQHGNFTVPEFNHKKAQSSLGSISKKQNSNDTATNRRINGSFTSSSSGHHIAMFRTPPLESGPLFKRPSLSSESAHHRSSSLQTSRSTNALLEDDSTKVDATDESATSLEKDFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRLAKERLLNDVDNLTREKDKQSASSRESLEQKENIATSITVKSPSSNSDRKGSISNASPKPRFWKIFSSAKDHQVGDLESQQRSPNSSSGGTTNIAQKEISSPKLIRVHDELPSPGKVPLSPSPKRLDYTPDGSHLYGSSLQARCAYEKSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLSPKLNALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLIHDFDGEKDIVDMKERNYIVEFILGNYRDIFKQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39PhosphorylationKWHDQCFTCYKCDKK
CCCCCCCEEEECCCC		23.6628889911
41PhosphorylationHDQCFTCYKCDKKLN
CCCCCEEEECCCCCC		16.1628889911
141PhosphorylationLENQTKNSSKEDFPI
HHCCCCCCCCCCCCC		44.3222369663
142PhosphorylationENQTKNSSKEDFPIK
HCCCCCCCCCCCCCC		49.8322369663
160PhosphorylationRSVKRPLSPTRINGK
CCCCCCCCCCCCCCC		27.2319823750
162PhosphorylationVKRPLSPTRINGKSD
CCCCCCCCCCCCCCC		40.5821440633
171PhosphorylationINGKSDVSTNNTAIS
CCCCCCCCCCCCHHH		30.3322369663
197PhosphorylationLTPQVLVSQERDESS
CCCEEEEECCCCHHH		23.3521551504
203PhosphorylationVSQERDESSLNDNND
EECCCCHHHCCCCCC		44.4029136822
204PhosphorylationSQERDESSLNDNNDN
ECCCCHHHCCCCCCC		29.1929136822
214PhosphorylationDNNDNDNSKDREETS
CCCCCCCCCCHHHHH		38.5028889911
226PhosphorylationETSSHARTVSIDDIL
HHHHHCEEEEHHHHH		21.2723607784
228PhosphorylationSSHARTVSIDDILNS
HHHCEEEEHHHHHHH		21.4923749301
235PhosphorylationSIDDILNSTLEHDSN
EHHHHHHHHCCCCCC		30.8121440633
236PhosphorylationIDDILNSTLEHDSNS
HHHHHHHHCCCCCCC		34.7823607784
241PhosphorylationNSTLEHDSNSIEEQS
HHHCCCCCCCHHHHH		34.0919779198
243PhosphorylationTLEHDSNSIEEQSLV
HCCCCCCCHHHHHHC		35.0223607784
248PhosphorylationSNSIEEQSLVDNEDY
CCCHHHHHHCCCHHH		33.3721440633
255PhosphorylationSLVDNEDYINKMGED
HHCCCHHHHHHHCCC		10.5423607784
277PhosphorylationPQRANRDSIVVKDPR
CCCCCCCCEEEECCC		17.6628889911
288PhosphorylationKDPRIPNSNSNANRF
ECCCCCCCCCCCCCE		35.9630377154
290PhosphorylationPRIPNSNSNANRFFS
CCCCCCCCCCCCEEE		36.8228889911
320PhosphorylationENEIIVNTPRNSTDK
CCEEEEECCCCCCCC		16.8422369663
324PhosphorylationIVNTPRNSTDKITSP
EEECCCCCCCCCCCC		38.9822369663
325PhosphorylationVNTPRNSTDKITSPL
EECCCCCCCCCCCCC		44.8822369663
334PhosphorylationKITSPLNSPMAVQMN
CCCCCCCCCCEEECC		24.6028889911
364PhosphorylationATKENNKSSQGIQTS
HHHHCCCCCCCCCCC		29.9828889911
370PhosphorylationKSSQGIQTSTSKSMN
CCCCCCCCCCCCCCC		31.8624930733
371PhosphorylationSSQGIQTSTSKSMNH
CCCCCCCCCCCCCCC		17.8224930733
375PhosphorylationIQTSTSKSMNHVSPI
CCCCCCCCCCCCCCC		25.2821440633
380PhosphorylationSKSMNHVSPITRTDT
CCCCCCCCCCCCCCE		11.7519823750
383PhosphorylationMNHVSPITRTDTVEM
CCCCCCCCCCCEEEE		30.7920377248
385PhosphorylationHVSPITRTDTVEMKT
CCCCCCCCCEEEEEE		27.6320377248
387PhosphorylationSPITRTDTVEMKTST
CCCCCCCEEEEEECC		20.1120377248
392PhosphorylationTDTVEMKTSTSSSTL
CCEEEEEECCCCCEE		35.6128889911
394PhosphorylationTVEMKTSTSSSTLRL
EEEEEECCCCCEEEE		37.5521440633
395PhosphorylationVEMKTSTSSSTLRLS
EEEEECCCCCEEEEC		23.2720377248
396PhosphorylationEMKTSTSSSTLRLSD
EEEECCCCCEEEECC		27.6821440633
397PhosphorylationMKTSTSSSTLRLSDN
EEECCCCCEEEECCC		31.0928889911
398PhosphorylationKTSTSSSTLRLSDNG
EECCCCCEEEECCCC		20.1824961812
406PhosphorylationLRLSDNGSFSRPQTA
EEECCCCCCCCCCCC		26.7221082442
408PhosphorylationLSDNGSFSRPQTADN
ECCCCCCCCCCCCCC		44.7628889911
425PhosphorylationPHKKVAPSPNKKLSR
CCCCCCCCCCCCCCC		31.2228889911
435PhosphorylationKKLSRSFSLKSKNFV
CCCCCEECCCCCCHH		35.8128889911
493PhosphorylationKAKKNPVSRGQSDST
HCCCCCCCCCCCCCC		31.7621440633
497PhosphorylationNPVSRGQSDSTIYNT
CCCCCCCCCCCHHHC		36.0321551504
499PhosphorylationVSRGQSDSTIYNTLP
CCCCCCCCCHHHCCC		23.1924961812
500PhosphorylationSRGQSDSTIYNTLPQ
CCCCCCCCHHHCCCC		32.2620377248
523PhosphorylationFNHKKAQSSLGSISK
CCHHHHHHHHHCCCC		32.1822369663
524PhosphorylationNHKKAQSSLGSISKK
CHHHHHHHHHCCCCC		25.3522369663
527PhosphorylationKAQSSLGSISKKQNS
HHHHHHHCCCCCCCC		29.0522369663
529PhosphorylationQSSLGSISKKQNSND
HHHHHCCCCCCCCCC		35.1822369663
546PhosphorylationTNRRINGSFTSSSSG
CCCEECCEEECCCCC		22.3619779198
549PhosphorylationRINGSFTSSSSGHHI
EECCEEECCCCCCEE		26.6419779198
561PhosphorylationHHIAMFRTPPLESGP
CEEEEEECCCCCCCC		20.2828889911
574PhosphorylationGPLFKRPSLSSESAH
CCCCCCCCCCCCCCC		44.9417563356
576PhosphorylationLFKRPSLSSESAHHR
CCCCCCCCCCCCCHH		36.0823749301
577PhosphorylationFKRPSLSSESAHHRS
CCCCCCCCCCCCHHH		40.6428889911
579PhosphorylationRPSLSSESAHHRSSS
CCCCCCCCCCHHHHH		34.5528889911
584PhosphorylationSESAHHRSSSLQTSR
CCCCCHHHHHCCCCH		21.6628889911
585PhosphorylationESAHHRSSSLQTSRS
CCCCHHHHHCCCCHH		34.7221082442
586PhosphorylationSAHHRSSSLQTSRST
CCCHHHHHCCCCHHH		26.2425752575
592PhosphorylationSSLQTSRSTNALLED
HHCCCCHHHCCCCCC		26.2722369663
593PhosphorylationSLQTSRSTNALLEDD
HCCCCHHHCCCCCCC		24.3324909858
601PhosphorylationNALLEDDSTKVDATD
CCCCCCCCCCCCCCC		42.3122369663
602PhosphorylationALLEDDSTKVDATDE
CCCCCCCCCCCCCCC		41.9222369663
607PhosphorylationDSTKVDATDESATSL
CCCCCCCCCCCCCHH		35.5222369663
610PhosphorylationKVDATDESATSLEKD
CCCCCCCCCCHHHHH		39.3929136822
612PhosphorylationDATDESATSLEKDFY
CCCCCCCCHHHHHHE		43.0229136822
613PhosphorylationATDESATSLEKDFYF
CCCCCCCHHHHHHEE		33.9628889911
686PhosphorylationEQKENIATSITVKSP
HHHHCEEEEEEEECC		19.5028889911
689PhosphorylationENIATSITVKSPSSN
HCEEEEEEEECCCCC		22.9621440633
692PhosphorylationATSITVKSPSSNSDR
EEEEEEECCCCCCCC		26.1928889911
697PhosphorylationVKSPSSNSDRKGSIS
EECCCCCCCCCCCCC		40.5121551504
700UbiquitinationPSSNSDRKGSISNAS
CCCCCCCCCCCCCCC		63.1023749301
702PhosphorylationSNSDRKGSISNASPK
CCCCCCCCCCCCCCC		26.3625533186
704PhosphorylationSDRKGSISNASPKPR
CCCCCCCCCCCCCCC		28.2120377248
707PhosphorylationKGSISNASPKPRFWK
CCCCCCCCCCCCHHH		37.3921551504
729PhosphorylationHQVGDLESQQRSPNS
CCCCCHHHCCCCCCC		38.6229136822
733PhosphorylationDLESQQRSPNSSSGG
CHHHCCCCCCCCCCC		24.8922369663
736PhosphorylationSQQRSPNSSSGGTTN
HCCCCCCCCCCCCCC		29.3022890988
737PhosphorylationQQRSPNSSSGGTTNI
CCCCCCCCCCCCCCH		39.3722890988
738PhosphorylationQRSPNSSSGGTTNIA
CCCCCCCCCCCCCHH		40.8522890988
741PhosphorylationPNSSSGGTTNIAQKE
CCCCCCCCCCHHHHH		21.8622890988
742PhosphorylationNSSSGGTTNIAQKEI
CCCCCCCCCHHHHHC		28.0919823750
750PhosphorylationNIAQKEISSPKLIRV
CHHHHHCCCCCEEEE		41.5021440633
751PhosphorylationIAQKEISSPKLIRVH
HHHHHCCCCCEEEEE		31.5428152593
763PhosphorylationRVHDELPSPGKVPLS
EEECCCCCCCCCCCC		59.9322369663
770PhosphorylationSPGKVPLSPSPKRLD
CCCCCCCCCCCCCCC		19.7722369663
772PhosphorylationGKVPLSPSPKRLDYT
CCCCCCCCCCCCCCC		39.4122369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGA2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGA2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGA2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RGA2_YEASTRGA2physical
11087867
MCK1_YEASTMCK1physical
16554755
ENT1_YEASTENT1physical
16537494
RGA2_YEASTRGA2physical
18467557
SSB1_YEASTSSB1physical
19536198
ASK10_YEASTASK10genetic
20093466
ROM2_YEASTROM2genetic
20093466
ELP1_YEASTIKI3genetic
20093466
SAM37_YEASTSAM37genetic
20093466
LSM7_YEASTLSM7genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
RGA2_YEASTRGA2physical
22615397
SPR3_YEASTSPR3physical
22875988
MRM2_YEASTMRM2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
DAL81_YEASTDAL81genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
NU133_YEASTNUP133genetic
27708008
NKP2_YEASTNKP2genetic
27708008
ARPC3_YEASTARC18genetic
27708008
ROM2_YEASTROM2genetic
27708008
ELP1_YEASTIKI3genetic
27708008
SAM37_YEASTSAM37genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
INO4_YEASTINO4genetic
27708008
PP2B1_YEASTCNA1physical
28077617
PP2B1_YEASTCNA1physical
24930733
PP2B2_YEASTCMP2physical
24930733
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGA2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142; SER-324; THR-325;SER-380; SER-523; SER-524; SER-763 AND SER-772, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524; SER-574; SER-702;SER-707; SER-763; SER-770 AND SER-772, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, AND MASSSPECTROMETRY.

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