PP2B1_YEAST - dbPTM
PP2B1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP2B1_YEAST
UniProt AC P23287
Protein Name Serine/threonine-protein phosphatase 2B catalytic subunit A1
Gene Name CNA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 553
Subcellular Localization
Protein Description Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin..
Protein Sequence MSKDLNSSRIKIIKPNDSYIKVDRKKDLTKYELENGKVISTKDRPIASVPAITGKIPSDEEVFDSKTGLPNHSFLREHFFHEGRLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVENYDDARDGSEFDQSEDEFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVTGFPSLITMFSAPNYLDTYHNKAAVLKYEENVMNIRQFHMSPHPYWLPDFMDVFTWSLPFVGEKVTSMLVSILNICSEQELDPESEPKAAEETVKARANATKETGTPSDEKASSAILEDETRRKALRNKILAIAKVSRMFSVLREESEKVEYLKTMNAGVLPRGALARGTEGLNETLSTFEKARKEDLINEKLPPSLSEVEQEKIKYYEKILKGAEKKPQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSKDLNSSR
------CCCCCCCCC		34.5722814378
7Phosphorylation-MSKDLNSSRIKIIK
-CCCCCCCCCEEEEC		28.4330377154
18PhosphorylationKIIKPNDSYIKVDRK
EEECCCCCCEEECCC		35.0821440633
19PhosphorylationIIKPNDSYIKVDRKK
EECCCCCCEEECCCC		13.9730377154
21AcetylationKPNDSYIKVDRKKDL
CCCCCCEEECCCCCC		29.8324489116
29PhosphorylationVDRKKDLTKYELENG
ECCCCCCCEEEECCC		41.5328889911
31PhosphorylationRKKDLTKYELENGKV
CCCCCCEEEECCCEE		22.1027017623
41PhosphorylationENGKVISTKDRPIAS
CCCEEEECCCCCCCC		26.3227017623
66AcetylationDEEVFDSKTGLPNHS
CHHHHCCCCCCCCCH		48.7524489116
190PhosphorylationKHLTSYFTFKNEMLH
CCCEEEEEECHHHHH		26.0124930733
280PhosphorylationDGSEFDQSEDEFVPN
CCCCCCCCCCCCCCC		49.1928889911
438PhosphorylationNATKETGTPSDEKAS
HCCCCCCCCCCHHHH		27.3423749301
443UbiquitinationTGTPSDEKASSAILE
CCCCCCHHHHHHHCC		59.5723749301
514AcetylationETLSTFEKARKEDLI
HHHHHHHHHHHHHHH		49.6624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PP2B1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP2B1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP2B1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SAY1_YEASTSAY1physical
11805837
CALM_YEASTCMD1physical
11805837
SLM2_YEASTSLM2physical
10688190
PP2B1_YEASTCNA1physical
7528690
CANB_YEASTCNB1physical
10373463
CALM_YEASTCMD1physical
10373463
LIC4_YEASTATC1physical
10102375
PP2B2_YEASTCMP2physical
1321337
CCC1_YEASTCCC1genetic
8668190
VCX1_YEASTVCX1genetic
8668190
LIC4_YEASTATC1genetic
10102375
STD1_YEASTSTD1genetic
9725828
FKS1_YEASTFKS1genetic
7510323
PP2B2_YEASTCMP2genetic
1651503
CALM_YEASTCMD1physical
16554755
CANB_YEASTCNB1physical
16554755
SLM1_YEASTSLM1physical
16959779
SLM1_YEASTSLM1physical
16738335
CANB_YEASTCNB1physical
17386265
SLM2_YEASTSLM2physical
17386265
HPH1_YEASTFRT1physical
19285944
SLM1_YEASTSLM1physical
19285944
RCN1_YEASTRCN1physical
19285944
CANB_YEASTCNB1physical
19285944
SLM2_YEASTSLM2physical
19285944
PP2B2_YEASTCMP2physical
19558332
SDO1L_YEASTRTC3genetic
20093466
SAC1_YEASTSAC1genetic
20093466
KTI12_YEASTKTI12genetic
20093466
YKH5_YEASTYKL075Cgenetic
20093466
FRMSR_YEASTYKL069Wgenetic
20093466
SOK2_YEASTSOK2genetic
20093466
NST1_YEASTNST1genetic
20093466
DOM34_YEASTDOM34genetic
20093466
CALM_YEASTCMD1physical
20489023
CANB_YEASTCNB1physical
20489023
LCF4_YEASTFAA4physical
20489023
MKT1_YEASTMKT1physical
20489023
PFKA2_YEASTPFK2physical
20489023
RCN1_YEASTRCN1physical
20489023
PP2B2_YEASTCMP2genetic
17030993
CTK2_YEASTCTK2genetic
21127252
CTK1_YEASTCTK1genetic
21127252
MSN4_YEASTMSN4genetic
21127252
RCK2_YEASTRCK2genetic
21127252
AFT1_YEASTAFT1genetic
21127252
HSP82_YEASTHSP82physical
23041319
HSC82_YEASTHSC82physical
23041319
ALY1_YEASTALY1physical
23824189
ROD1_YEASTROD1physical
24820415
ALY2_YEASTALY2physical
23824189
WDR59_YEASTMTC5genetic
27708008
MED5_YEASTNUT1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
VPS13_YEASTVPS13genetic
27708008
UBX2_YEASTUBX2genetic
27708008
VPS27_YEASTVPS27genetic
27708008
VAM10_YEASTVAM10genetic
27708008
MED1_YEASTMED1genetic
27708008
HDA3_YEASTHDA3genetic
27708008
HCM1_YEASTHCM1physical
26269584
RGA2_YEASTRGA2physical
28077617
CRZ1_YEASTCRZ1physical
24930733
RCN1_YEASTRCN1physical
24930733
ALY1_YEASTALY1physical
24930733
DIG2_YEASTDIG2physical
24930733
TDA1_YEASTTDA1physical
24930733
RGA2_YEASTRGA2physical
24930733
UBX7_YEASTUBX7physical
24930733
ROD1_YEASTROD1physical
24930733
UME6_YEASTUME6physical
24930733
ELM1_YEASTELM1physical
24930733
AIM3_YEASTAIM3physical
24930733
MLF3_YEASTMLF3physical
24930733
SFB3_YEASTSFB3physical
24930733
BOI2_YEASTBOI2physical
24930733
SKG3_YEASTSKG3physical
24930733
ATG13_YEASTATG13physical
24930733
2A5D_YEASTRTS1physical
24930733
ZRG17_YEASTZRG17physical
24930733
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP2B1_YEAST

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Related Literatures of Post-Translational Modification

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