SLM2_YEAST - dbPTM
SLM2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLM2_YEAST
UniProt AC P53955
Protein Name Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2
Gene Name SLM2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 656
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description Together with SLM1, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin, inhibiting interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis..
Protein Sequence MSYQRNSARASLDLRSQYQQLEGRMRSEHFNPAYQQQQQKGQNIPLSLPSSLAQRNPIPYPIDAVTSDPTIPAQLNVYDHDRQNSIVDAAAGTNTTHSLNSNNIPSSQNNNINNNNINNVGSFTDPSMLTLPKMSLHSHQKQYDSNQNDPRSPLAILIPTSAQPTDVLSARFSAWRNVIRAILVYLSETASIQDEIVRQQLRLSHAVQFPFFSIENQYQPVSNEDKSMQKFFLPLGSGSVQDLPTMLTKYHDNLASLASKSSKELTSEIIPRLEDLRRDLLVKIKEIKALQSDFKNSCNKELQQTKHLMKLFNESLKECKLGTPKSDPFLIKLQLEKQIKRQLVEENYLHEAFDNLQNSGAQLESVIVMEIQNGLTSYARILGKEAQVVFDSVISKLDSTILNKNTNLEWDSFILRNISNFVPPNLPMRRFKEISYSNQNDPFTFEVKSGFLEKRSKFLKSYSRGFYVLTPSFLHEFKTPDKHKFSTPLMSIPLVECTVTEHSKKTKSNSEQGKNKFILRTNSNGLIHRGHNWVFKVDSYDDMIEWFGNIKALSSLPNYDDKCKYVSKVAKLSKEKAKSNENTTESVTPQVTNEQHTRYDDVSSSNFPLNSIPKLDNLTITNTTSSIPETNDSQIQNRVPEFYIENVDSPRKSNQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MSYQRNSARASLDL
-CCCCHHCHHHHHHH		22.7128889911
11PhosphorylationQRNSARASLDLRSQY
CHHCHHHHHHHHHHH		19.5028889911
40UbiquitinationAYQQQQQKGQNIPLS
HHHHHHHCCCCCCCC		59.1117644757
47PhosphorylationKGQNIPLSLPSSLAQ
CCCCCCCCCCHHHHH		32.6419684113
50PhosphorylationNIPLSLPSSLAQRNP
CCCCCCCHHHHHHCC		43.1928889911
51PhosphorylationIPLSLPSSLAQRNPI
CCCCCCHHHHHHCCC		26.2828889911
226UbiquitinationQPVSNEDKSMQKFFL
CCCCCCCHHHHHEEE		41.4717644757
384UbiquitinationSYARILGKEAQVVFD
HHHHHHCHHHHHHHH		46.5624961812
523PhosphorylationKFILRTNSNGLIHRG
CEEEEECCCCCEECC		31.4927214570
578UbiquitinationKLSKEKAKSNENTTE
HHCHHHHHCCCCCCC		65.9523749301
586PhosphorylationSNENTTESVTPQVTN
CCCCCCCCCCCCCCC		29.2423749301
588PhosphorylationENTTESVTPQVTNEQ
CCCCCCCCCCCCCCC		19.7929136822
592PhosphorylationESVTPQVTNEQHTRY
CCCCCCCCCCCCCCC		27.9923749301
603PhosphorylationHTRYDDVSSSNFPLN
CCCCCCCCCCCCCCC		34.7423749301
604PhosphorylationTRYDDVSSSNFPLNS
CCCCCCCCCCCCCCC		29.2023749301
605PhosphorylationRYDDVSSSNFPLNSI
CCCCCCCCCCCCCCC		34.6821440633
611PhosphorylationSSNFPLNSIPKLDNL
CCCCCCCCCCCCCCE		48.2021551504
619PhosphorylationIPKLDNLTITNTTSS
CCCCCCEEEECCCCC		31.8221440633
621PhosphorylationKLDNLTITNTTSSIP
CCCCEEEECCCCCCC		22.6830377154
623PhosphorylationDNLTITNTTSSIPET
CCEEEECCCCCCCCC		21.2927738172
624PhosphorylationNLTITNTTSSIPETN
CEEEECCCCCCCCCC		23.6521440633
625PhosphorylationLTITNTTSSIPETND
EEEECCCCCCCCCCH		25.0020377248
626PhosphorylationTITNTTSSIPETNDS
EEECCCCCCCCCCHH		39.8219779198
630PhosphorylationTTSSIPETNDSQIQN
CCCCCCCCCHHHHHH		38.6821440633
643PhosphorylationQNRVPEFYIENVDSP
HHHCCEEEEECCCCC		12.9821440633
649PhosphorylationFYIENVDSPRKSNQL
EEEECCCCCCCCCCC		23.4817330950
652UbiquitinationENVDSPRKSNQL---
ECCCCCCCCCCC---		58.0823749301
653PhosphorylationNVDSPRKSNQL----
CCCCCCCCCCC----		30.9625752575
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLM2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLM2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLM2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AVO2_YEASTAVO2physical
15689497
BIT61_YEASTBIT61physical
15689497
BIT2_YEASTBIT2physical
15689497
TOR2_YEASTTOR2physical
15689497
INP51_YEASTINP51genetic
15689497
KPC1_YEASTPKC1genetic
15689497
RHO1_YEASTRHO1genetic
15689497
RHO2_YEASTRHO2genetic
15689497
KPC1_YEASTPKC1genetic
15372071
SEC4_YEASTSEC4genetic
15372071
SAC7_YEASTSAC7genetic
15372071
MSS4_YEASTMSS4genetic
15372071
TOR2_YEASTTOR2physical
18552287
PP2B2_YEASTCMP2physical
16847337
CANB_YEASTCNB1genetic
16847337
ISC1_YEASTISC1genetic
16847337
TPM1_YEASTTPM1genetic
20526336
BLI1_YEASTBLI1genetic
20526336
RGT2_YEASTRGT2genetic
21987634
SLM1_YEASTSLM1genetic
21987634
UBX2_YEASTUBX2genetic
21987634
CYK2_YEASTHOF1genetic
21987634
TPM1_YEASTTPM1genetic
21987634
PHO91_YEASTPHO91genetic
21987634
SAC7_YEASTSAC7genetic
22307609
YPK1_YEASTYPK1genetic
22307609
SEC9_YEASTSEC9genetic
23891562
PRP28_YEASTPRP28genetic
27708008
RRP45_YEASTRRP45genetic
27708008
SRPR_YEASTSRP101genetic
27708008
BCP1_YEASTBCP1genetic
27708008
COG3_YEASTCOG3genetic
27708008
ESP1_YEASTESP1genetic
27708008
MET30_YEASTMET30genetic
27708008
RHO3_YEASTRHO3genetic
27708008
EXO70_YEASTEXO70genetic
27708008
CDC16_YEASTCDC16genetic
27708008
SPC3_YEASTSPC3genetic
27708008
SC61A_YEASTSEC61genetic
27708008
RNA1_YEASTRNA1genetic
27708008
OST2_YEASTOST2genetic
27708008
AIM18_YEASTAIM18genetic
27708008
BFA1_YEASTBFA1genetic
27708008
INO4_YEASTINO4genetic
27708008
RAD1_YEASTRAD1genetic
27708008
CDC24_YEASTCDC24genetic
27708008
STU1_YEASTSTU1genetic
27708008
DPOA2_YEASTPOL12genetic
27708008
ORC2_YEASTORC2genetic
27708008
SLI15_YEASTSLI15genetic
27708008
KRR1_YEASTKRR1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
ARP2_YEASTARP2genetic
27708008
FAD1_YEASTFAD1genetic
27708008
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
CDC53_YEASTCDC53genetic
27708008
UPPS_YEASTNUS1genetic
27708008
SEC31_YEASTSEC31genetic
27708008
TPIS_YEASTTPI1genetic
27708008
SLU7_YEASTSLU7genetic
27708008
MSS4_YEASTMSS4genetic
27708008
PRP3_YEASTPRP3genetic
27708008
TSC11_YEASTTSC11genetic
27708008
SCC4_YEASTSCC4genetic
27708008
RCC1_YEASTSRM1genetic
27708008
MCE1_YEASTCEG1genetic
27708008
SNU71_YEASTSNU71genetic
27708008
PRP31_YEASTPRP31genetic
27708008
DAM1_YEASTDAM1genetic
27708008
CBF3A_YEASTCBF2genetic
27708008
YHI0_YEASTYHR020Wgenetic
27708008
CDC12_YEASTCDC12genetic
27708008
SPC97_YEASTSPC97genetic
27708008
MOB1_YEASTMOB1genetic
27708008
NDC80_YEASTNDC80genetic
27708008
HACD_YEASTPHS1genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
CDC11_YEASTCDC11genetic
27708008
SWD2_YEASTSWD2genetic
27708008
MAK11_YEASTMAK11genetic
27708008
UGPA1_YEASTUGP1genetic
27708008
PRI2_YEASTPRI2genetic
27708008
GFA1_YEASTGFA1genetic
27708008
HYM1_YEASTHYM1genetic
27708008
YKT6_YEASTYKT6genetic
27708008
DAD2_YEASTDAD2genetic
27708008
ORC3_YEASTORC3genetic
27708008
STU2_YEASTSTU2genetic
27708008
SEC22_YEASTSEC22genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
RU1C_YEASTYHC1genetic
27708008
CDC3_YEASTCDC3genetic
27708008
RLA0_YEASTRPP0genetic
27708008
IMB1_YEASTKAP95genetic
27708008
NBP1_YEASTNBP1genetic
27708008
TAF11_YEASTTAF11genetic
27708008
MCM1_YEASTMCM1genetic
27708008
CBF3C_YEASTCTF13genetic
27708008
CEF1_YEASTCEF1genetic
27708008
RRP44_YEASTDIS3genetic
27708008
XRN2_YEASTRAT1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
ESA1_YEASTESA1genetic
27708008
RAEP_YEASTMRS6genetic
27708008
MEX67_YEASTMEX67genetic
27708008
IPL1_YEASTIPL1genetic
27708008
CET1_YEASTCET1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
SWD1_YEASTSWD1genetic
27708008
AIM4_YEASTAIM4genetic
27708008
CG23_YEASTCLB3genetic
27708008
SWR1_YEASTSWR1genetic
27708008
SDC1_YEASTSDC1genetic
27708008
BCK2_YEASTBCK2genetic
27708008
IES1_YEASTIES1genetic
27708008
MED5_YEASTNUT1genetic
27708008
OPI1_YEASTOPI1genetic
27708008
PTH_YEASTPTH1genetic
27708008
SLM1_YEASTSLM1genetic
27708008
SIC1_YEASTSIC1genetic
27708008
IRC21_YEASTIRC21genetic
27708008
YO087_YEASTDUF1genetic
27708008
SVL3_YEASTSVL3genetic
27708008
LGE1_YEASTLGE1genetic
27708008
NIP80_YEASTNIP100genetic
27708008
AXL1_YEASTAXL1genetic
27708008
HDA3_YEASTHDA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLM2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-624; SER-626; SER-649AND SER-653, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, AND MASSSPECTROMETRY.

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