dbPTM

YO087_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YO087_YEAST
UniProt AC	Q99247
Protein Name	Uncharacterized WD repeat-containing protein YOL087C
Gene Name	YOL087C
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1116
Subcellular Localization	Cytoplasm .
Protein Description	Involved in the resistance to phenanthroline, sanguinarine, nordihydroguaiaretic acid (NDGA), isopropyl (N-3-chloro-phenyl)-carbamate (IPCPC) and guanosine 5'-O-(2-thiodiphosphate)..
Protein Sequence	MNQLTVSYGLISPDYCTSQDAHILPITKILYPDIPGKNYFLTSGRDGSIILHKNTQLSNEPETAATTIKNDAIRMQVHSDWASDLIHVNMKNSDPSAGDTFISVSHDFSIVLISVNAQLTTWDKKIIGDHDDYIKCIVPIHYEMSNDYELEEQEGGPDNVHDGINNGIVVDEQNNFLFVTGGLDRKIKLWCLSSGPEKMATLLHTFDNAQSNDTGSIYSMSPIIPKYSFDDNQTSRPFDFVAGDCNGDLIFYSCKYRKEVIRIQNAHRTNIKVVRTLDDSTRLISTSSDGVINVWDLNCRHDQTTGALQLPKKIGSWSWDSSIWCVQGTSLDKLYFGDSQGNVMRANLSSYEDAKLTRIFKPDHHHHHHHHHEHEEQNISTTDAKVKKYGGILDIALLPNEKLLFSFCTDSNLNVLDLTNNHFSVNEGGFALTRSSLLTNRRHVITENTKGQMQRWDIVSCELLNTFDSSEGSFDDIVMKYTSKEILSHWCTVSVKVGMLFVKINPKFLKTEVYGSALKDYQVVNNIEINSDERYNLGKIVINSLFNEFISYEVQKDKLLRKKIFSLKKKDLTNSLTLDTGYNSESKKNNKDKKRKSTFKISSTLSIGNTNSSGTPPNSAPATPVMAETIVLEEQPLLQSASDKAIDDSLELVQPLPASKKPYFRTQSSGSLLSRKFKSFRSTSGRATTGLNTPEEPKGILPDTPHVINDDSAFPQAINTTQQSKDATPESMLWNHPFKLEQKLSAISSQDLPSNNTHNKLRSSENSRANSTSTLEGNEKKKPEFMPDLLEQIQESYKQQYMNTSSLKYLTKRLPVTKIIKASSCPIIRVKSATLVLVHLWKEGSCGGRVLFSTLLPPSHVDNETVSGGKENSKPPDDEEVDLQAVDDDKLGKYDLIDGELGSRLNRRQIFEQLEENLPYWFAKALFRDIKTVEEQPKLNFLIMPWSSVGGSEAAGNENKKKFISASDTTESSGNDSSDSSLGNGNEAVSPSTQQQFHNMLKFGRPKTSEQELNPTDLPRISEANVKLVAPGMIRVKKIKLYVADRFETKTPEMKAKMEPSLWLDLLCRGQVLDNDMTLNTVRTLYWKSQGDIVLEYRRKVHNSPLVHEVNGNEGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
510	Acetylation	KINPKFLKTEVYGSA EECHHHCCEEEECHH	45.85	24489116
760	Acetylation	PSNNTHNKLRSSENS CCCCHHHHHHCCCCC	37.36	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YO087_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YO087_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YO087_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H2B2_YEAST	HTB2	physical	11805837
VDAC1_YEAST	POR1	physical	11805837
UBI4P_YEAST	UBI4	physical	11805837
EIF3G_YEAST	TIF35	physical	11805837
EIF3I_YEAST	TIF34	physical	11805837
GCH1_YEAST	FOL2	physical	11805837
COPA_YEAST	COP1	physical	11805837
CAP_YEAST	SRV2	physical	11805837
EIF3C_YEAST	NIP1	physical	11805837
ATPG_YEAST	ATP3	physical	11805837
LHS1_YEAST	LHS1	physical	11805837
SYSC_YEAST	SES1	physical	11805837
EIF3A_YEAST	RPG1	physical	11805837
BEM2_YEAST	BEM2	physical	11805837
EDE1_YEAST	EDE1	physical	11805837
SSB2_YEAST	SSB2	physical	16554755
UBP13_YEAST	UBP13	physical	22723847
UBP9_YEAST	UBP9	physical	22723847
HTD2_YEAST	HTD2	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
BRE1_YEAST	BRE1	genetic	27708008
ARO1_YEAST	ARO1	genetic	27708008
SNF1_YEAST	SNF1	genetic	27708008
AROC_YEAST	ARO2	genetic	27708008
VAM7_YEAST	VAM7	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
PSA3_YEAST	PRE9	genetic	27708008
WSS1_YEAST	WSS1	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
PEP8_YEAST	PEP8	genetic	27708008
VPS51_YEAST	VPS51	genetic	27708008
CSF1_YEAST	CSF1	genetic	27708008
ORM2_YEAST	ORM2	genetic	27708008
RAD14_YEAST	RAD14	genetic	27708008
PHO80_YEAST	PHO80	genetic	27708008
LGE1_YEAST	LGE1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YO087_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668; SER-669; THR-693AND SER-771, AND MASS SPECTROMETRY.	18407956 [Abstract]