| UniProt ID | PEP8_YEAST | |
|---|---|---|
| UniProt AC | P40335 | |
| Protein Name | Carboxypeptidase Y-deficient protein 8 | |
| Gene Name | PEP8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 379 | |
| Subcellular Localization | ||
| Protein Description | Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection.. | |
| Protein Sequence | MSIFFKPPIDIEILFDNEESRKHVDIATRSSNSSYKSMKESLPVYEDGESLGGIVTLRVRDSKKVDHLGIKVSVIGSIDMLKSHGSGNSSSKKVTSSTSSSSSNGSVDVRKNSVDQFLCQSYDLCPAGELQHSQSFPFLFRDLSKRYESYKGKNVDVAYYVKVTVMRKSTDISKIKRFWVYLYNSVTTAPNTLSANETKATTNDIAGGNYAADNASDNTQTKSTQGEAADVNQVLPISHSNNEPKPVRLDIGIENCLHIEFEYAKSQYSLKEVIVGRIYFLLTRLRIKHMELSLITRESSGLQTSNVMTDSTAIRYEIMDGSSVKGETIPIRLFLSGYDLTPNMSCNYFNVKNYLSLVIIDEDGRRYFKQSEITLYRTR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Phosphorylation | HVDIATRSSNSSYKS CEEEEECCCCCCHHH | 29.53 | 21440633 | |
| 31 | Phosphorylation | VDIATRSSNSSYKSM EEEEECCCCCCHHHH | 37.12 | 21440633 | |
| 37 | Phosphorylation | SSNSSYKSMKESLPV CCCCCHHHHHHHCCE | 27.18 | 27017623 | |
| 41 | Phosphorylation | SYKSMKESLPVYEDG CHHHHHHHCCEECCC | 32.24 | 27017623 | |
| 82 | Acetylation | IGSIDMLKSHGSGNS EEEHHHHHHCCCCCC | 33.49 | 24489116 | |
| 93 | Ubiquitination | SGNSSSKKVTSSTSS CCCCCCCEEECCCCC | 53.33 | 23749301 | |
| 99 | Phosphorylation | KKVTSSTSSSSSNGS CEEECCCCCCCCCCC | 30.12 | 28889911 | |
| 100 | Phosphorylation | KVTSSTSSSSSNGSV EEECCCCCCCCCCCE | 34.04 | 27017623 | |
| 102 | Phosphorylation | TSSTSSSSSNGSVDV ECCCCCCCCCCCEEE | 29.75 | 28889911 | |
| 103 | Phosphorylation | SSTSSSSSNGSVDVR CCCCCCCCCCCEEEE | 47.35 | 28889911 | |
| 106 | Phosphorylation | SSSSSNGSVDVRKNS CCCCCCCCEEEECCC | 21.28 | 28889911 | |
| 147 | Phosphorylation | FRDLSKRYESYKGKN HHHHHHHHHHHCCCC | 16.98 | 28889911 | |
| 149 | Phosphorylation | DLSKRYESYKGKNVD HHHHHHHHHCCCCCE | 24.18 | 28889911 | |
| 150 | Phosphorylation | LSKRYESYKGKNVDV HHHHHHHHCCCCCEE | 16.30 | 28889911 | |
| 168 | Acetylation | VKVTVMRKSTDISKI EEEEEEECCCCHHHC | 39.34 | 25381059 | |
| 201 | Phosphorylation | SANETKATTNDIAGG CCCCCCCCCCCCCCC | 27.91 | 28889911 | |
| 210 | Phosphorylation | NDIAGGNYAADNASD CCCCCCCCCCCCCCC | 13.36 | 28889911 | |
| 216 | Phosphorylation | NYAADNASDNTQTKS CCCCCCCCCCCCCCC | 37.33 | 22369663 | |
| 219 | Phosphorylation | ADNASDNTQTKSTQG CCCCCCCCCCCCCCC | 42.48 | 20377248 | |
| 221 | Phosphorylation | NASDNTQTKSTQGEA CCCCCCCCCCCCCCC | 25.56 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PEP8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PEP8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PEP8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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