BDF2_YEAST - dbPTM
BDF2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BDF2_YEAST
UniProt AC Q07442
Protein Name Bromodomain-containing factor 2
Gene Name BDF2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 638
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity)..
Protein Sequence MSRTNMDTRHAHSALLAAPQSATANSRSSNSSSESSSNKNNINVGVGDDSGNVSAVSIDDGPHFRDIFHYGHEENYKLASSGITNLNSSSHAHQTLSPISISNASTPESFPEHPLGLERETEPALEAEMEAEELPPHQSKYLLSSIKATKRLKDARPFLKPVDPIALNIPHYFNYVQTPMDLSLIETKLQGNVYHSVEQVTSDFKTMVDNCLNFNGPESSISSMAKRIQKYFEKKLSAMPPRVLPASALKKTSRNRKKNEDMDSPLVIRRSVSTTNDNIGESGNREGVSGGRPKRTIHPPKSKDLFDIYENSKPKSKTLQKKFRTCLKILKVLMSKKNSDINFPFLQPVDPIALNLPNYFDVVKNPMDLGTISNNLMNWKYKTIDQFVDDLNLVFYNCFQFNPEGNEVHSMGKKLKELFNFHWLENQDILNEIETDSDLEEDNYSSSYSSDDEYDDEDINENDITNPAIQYLEQKLKKMEVELQQLKRQELSKLSKERKRKHLGKTLLRRKAMKHSVDDLKKSITDKINELSDLEMNGMIRIIKNSLPADEILTSNEDEIEIDLDILDEATIARIYERYFEKKNNNNSKRKLSGNYSTAPTNKKKKTLKFLEKDEIINNNNYSDSEEDSSDSSDSDSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50PhosphorylationNVGVGDDSGNVSAVS
EEECCCCCCCEEEEE		36.6919779198
54PhosphorylationGDDSGNVSAVSIDDG
CCCCCCEEEEECCCC		27.2719779198
57PhosphorylationSGNVSAVSIDDGPHF
CCCEEEEECCCCCCH		21.7319779198
141PhosphorylationLPPHQSKYLLSSIKA
CCHHHHHHHHHHHHH		20.3730377154
145PhosphorylationQSKYLLSSIKATKRL
HHHHHHHHHHHHHHH		28.2530377154
264PhosphorylationKKNEDMDSPLVIRRS
HCCCCCCCCCEEEEC		17.3117330950
271PhosphorylationSPLVIRRSVSTTNDN
CCCEEEECEECCCCC		15.5722369663
273PhosphorylationLVIRRSVSTTNDNIG
CEEEECEECCCCCCC		30.6622369663
274PhosphorylationVIRRSVSTTNDNIGE
EEEECEECCCCCCCC		27.7122369663
275PhosphorylationIRRSVSTTNDNIGES
EEECEECCCCCCCCC		32.8221440633
505AcetylationRKRKHLGKTLLRRKA
HHHHHHHHHHHHHHH		42.2225381059
525PhosphorylationDDLKKSITDKINELS
HHHHHHHHHHHHHHH		38.0321440633
532PhosphorylationTDKINELSDLEMNGM
HHHHHHHHHHHHHHH		33.6921440633
544UbiquitinationNGMIRIIKNSLPADE
HHHHHHHHCCCCHHH		37.8117644757
593PhosphorylationNNSKRKLSGNYSTAP
CCCCCCCCCCCCCCC		28.2019823750
596PhosphorylationKRKLSGNYSTAPTNK
CCCCCCCCCCCCCCC		15.7821440633
597PhosphorylationRKLSGNYSTAPTNKK
CCCCCCCCCCCCCCC		23.3027214570
598PhosphorylationKLSGNYSTAPTNKKK
CCCCCCCCCCCCCCC		26.7130377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BDF2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BDF2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BDF2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BDF1_YEASTBDF1physical
11805826
ASF1_YEASTASF1physical
12093919
H2A2_YEASTHTA2physical
16554755
YRA1_YEASTYRA1physical
16554755
BDF1_YEASTBDF1physical
16554755
UBC4_YEASTUBC4genetic
17314980
SWC5_YEASTSWC5genetic
17314980
AF9_YEASTYAF9genetic
19547744
PFD5_YEASTGIM5genetic
19547744
GAL3_YEASTGAL3genetic
19547744
BUB3_YEASTBUB3genetic
20959818
MED1_YEASTMED1genetic
20959818
H2AZ_YEASTHTZ1genetic
20959818
VPS72_YEASTVPS72genetic
20959818
BUB1_YEASTBUB1genetic
20959818
PFD1_YEASTPFD1genetic
20959818
PFD2_YEASTGIM4genetic
20959818
SIN3_YEASTSIN3genetic
20959818
VPS71_YEASTVPS71genetic
20959818
MED9_YEASTCSE2genetic
20959818
SSN3_YEASTSSN3genetic
20959818
GAL3_YEASTGAL3genetic
20959818
PFD5_YEASTGIM5genetic
20959818
AF9_YEASTYAF9genetic
20959818
DOA1_YEASTDOA1genetic
20959818
MUM2_YEASTMUM2physical
22875988
YSP2_YEASTYSP2physical
22875988
LAM4_YEASTYHR080Cphysical
22875988
MDM1_YEASTMDM1physical
22875988
BDF1_YEASTBDF1physical
23452060
TPS1_YEASTTPS1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
YOR1_YEASTYOR1genetic
27708008
AIR1_YEASTAIR1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
SWC3_YEASTSWC3genetic
27708008
DCC1_YEASTDCC1genetic
27708008
ELO2_YEASTELO2genetic
27708008
UME6_YEASTUME6genetic
27708008
SWR1_YEASTSWR1genetic
27708008
VPS72_YEASTVPS72genetic
27708008
AIM11_YEASTAIM11genetic
27708008
MGDP1_YEASTYER134Cgenetic
27708008
TFS2_YEASTDST1genetic
27708008
ACOX_YEASTPOX1genetic
27708008
BUB1_YEASTBUB1genetic
27708008
TBP7_YEASTYTA7genetic
27708008
SSBP1_YEASTSBP1genetic
27708008
YHK5_YEASTYHR045Wgenetic
27708008
URM1_YEASTURM1genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
CBF1_YEASTCBF1genetic
27708008
AIM24_YEASTAIM24genetic
27708008
EF1G2_YEASTTEF4genetic
27708008
CTK1_YEASTCTK1genetic
27708008
MIC60_YEASTMIC60genetic
27708008
TVP38_YEASTTVP38genetic
27708008
ARP6_YEASTARP6genetic
27708008
VPS71_YEASTVPS71genetic
27708008
YME2_YEASTYME2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
BUB3_YEASTBUB3genetic
27708008
SERC_YEASTSER1genetic
27708008
YO268_YEASTYOR268Cgenetic
27708008
EAF3_YEASTEAF3genetic
27708008
MED1_YEASTMED1genetic
27708008
BDF1_YEASTBDF1physical
28068333
H2AZ_YEASTHTZ1genetic
27453043
VPS72_YEASTVPS72genetic
27453043
INO2_YEASTINO2genetic
27453043
PGTB2_YEASTBET2genetic
27453043
CTK2_YEASTCTK2genetic
27453043
SWI6_YEASTSWI6genetic
27453043
VPS1_YEASTVPS1genetic
27453043
SWC5_YEASTSWC5genetic
27453043
DCAM_YEASTSPE2genetic
27453043
LSM1_YEASTLSM1genetic
27453043
CBF1_YEASTCBF1genetic
27453043
RCO1_YEASTRCO1genetic
27453043
DCOR_YEASTSPE1genetic
27453043
VPS71_YEASTVPS71genetic
27453043
VPS53_YEASTVPS53genetic
27453043
SIN3_YEASTSIN3genetic
27453043
RPD3_YEASTRPD3genetic
27453043
SET2_YEASTSET2genetic
27453043
CTK3_YEASTCTK3genetic
27453043
SSN3_YEASTSSN3genetic
27453043
TOR1_YEASTTOR1genetic
27453043
PP12_YEASTGLC7genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BDF2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273 AND SER-593, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264, AND MASSSPECTROMETRY.

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