| UniProt ID | UME6_YEAST | |
|---|---|---|
| UniProt AC | P39001 | |
| Protein Name | Transcriptional regulatory protein UME6 | |
| Gene Name | UME6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 836 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Binds to the URS1 site (5'-AGCCGCCGA-3') and recruits the RPD3 histone deacetylase complex to the promoters to negatively regulate the expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. Recruits also the ISW2 chromatin remodeling complex to promoters in a second gene repression pathway. Associates with the master regulator of meiosis IME1 in order to activate the expression of meiosis genes. Has both a positive and negative role in regulating phospholipid biosynthesis.. | |
| Protein Sequence | MLDKARSQSKHMDESNAAASLLSMETTANNHHYLHNKTSRATLMNSSQDGKKHAEDEVSDGANSRHPTISSASIESLKTTYDENPLLSIMKSTCAPNNTPVHTPSGSPSLKVQSGGDIKDDPKENDTTTTTNTTLQDRRDSDNAVHAAASPLAPSNTPSDPKSLCNGHVAQATDPQISGAIQPQYTATNEDVFPYSSTSTNSNTATTTIVAGAKKKIHLPPPQAPAVSSPGTTAAGSGAGTGSGIRSRTGSDLPLIITSANKNNGKTTNSPMSILSRNNSTNNNDNNSIQSSDSRESSNNNEIGGYLRGGTKRGGSPSNDSQVQHNVHDDQCAVGVAPRNFYFNKDREITDPNVKLDENESKINISFWLNSKYRDEAYSLNESSSNNASSNTDTPTNSRHANTSSSITSRNNFQHFRFNQIPSQPPTSASSFTSTNNNNPQRNNINRGEDPFATSSRPSTGFFYGDLPNRNNRNSPFHTNEQYIPPPPPKYINSKLDGLRSRLLLGPNSASSSTKLDDDLGTAAAVLSNMRSSPYRTHDKPISNVNDMNNTNALGVPASRPHSSSFPSKGVLRPILLRIHNSEQQPIFESNNSTAVFDEDQDQNQDLSPYHLNLNSKKVLDPTFESRTRQVTWNKNGKRIDRRLSAPEQQQQLEVPPLKKSRRSVGNARVASQTNSDYNSLGESSTSSAPSSPSLKASSGLAYTADYPNATSPDFAKSKGKNVKPKAKSKAKQSSKKRPNNTTSKSKANNSQESNNATSSTSQGTRSRTGCWICRLRKKKCTEERPHCFNCERLKLDCHYDAFKPDFVSDPKKKQMKLEEIKKKTKEAKRRAMKKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MLDKARSQSKHMDE -CHHHHHHHHHCCCH | 43.60 | 19823750 | |
| 9 | Phosphorylation | LDKARSQSKHMDESN HHHHHHHHHCCCHHH | 26.27 | 19823750 | |
| 15 | Phosphorylation | QSKHMDESNAAASLL HHHCCCHHHHHHHHH | 27.75 | 19823750 | |
| 20 | Phosphorylation | DESNAAASLLSMETT CHHHHHHHHHHHHHC | 25.72 | 19823750 | |
| 23 | Phosphorylation | NAAASLLSMETTANN HHHHHHHHHHHCCCC | 21.62 | 19823750 | |
| 26 | Phosphorylation | ASLLSMETTANNHHY HHHHHHHHCCCCCCC | 23.67 | 19823750 | |
| 27 | Phosphorylation | SLLSMETTANNHHYL HHHHHHHCCCCCCCC | 17.68 | 19823750 | |
| 33 | Phosphorylation | TTANNHHYLHNKTSR HCCCCCCCCCCCCCH | 11.34 | 21551504 | |
| 38 | Phosphorylation | HHYLHNKTSRATLMN CCCCCCCCCHHHHCC | 28.85 | 28889911 | |
| 39 | Phosphorylation | HYLHNKTSRATLMNS CCCCCCCCHHHHCCC | 22.87 | 26447709 | |
| 42 | Phosphorylation | HNKTSRATLMNSSQD CCCCCHHHHCCCCCC | 25.98 | 21551504 | |
| 46 | Phosphorylation | SRATLMNSSQDGKKH CHHHHCCCCCCCHHH | 18.53 | 28889911 | |
| 47 | Phosphorylation | RATLMNSSQDGKKHA HHHHCCCCCCCHHHC | 27.56 | 23749301 | |
| 59 | Phosphorylation | KHAEDEVSDGANSRH HHCHHHCCCCCCCCC | 28.42 | 22369663 | |
| 64 | Phosphorylation | EVSDGANSRHPTISS HCCCCCCCCCCCCCH | 31.28 | 22369663 | |
| 68 | Phosphorylation | GANSRHPTISSASIE CCCCCCCCCCHHHHH | 27.63 | 22369663 | |
| 70 | Phosphorylation | NSRHPTISSASIESL CCCCCCCCHHHHHHH | 23.48 | 22369663 | |
| 71 | Phosphorylation | SRHPTISSASIESLK CCCCCCCHHHHHHHH | 23.37 | 22369663 | |
| 73 | Phosphorylation | HPTISSASIESLKTT CCCCCHHHHHHHHCC | 28.92 | 22369663 | |
| 76 | Phosphorylation | ISSASIESLKTTYDE CCHHHHHHHHCCCCC | 33.23 | 22369663 | |
| 92 | Phosphorylation | PLLSIMKSTCAPNNT CHHHHHHHCCCCCCC | 16.02 | 22369663 | |
| 93 | Phosphorylation | LLSIMKSTCAPNNTP HHHHHHHCCCCCCCC | 13.73 | 22369663 | |
| 99 | Phosphorylation | STCAPNNTPVHTPSG HCCCCCCCCCCCCCC | 33.07 | 22369663 | |
| 103 | Phosphorylation | PNNTPVHTPSGSPSL CCCCCCCCCCCCCCC | 21.27 | 22369663 | |
| 105 | Phosphorylation | NTPVHTPSGSPSLKV CCCCCCCCCCCCCEE | 53.73 | 20377248 | |
| 107 | Phosphorylation | PVHTPSGSPSLKVQS CCCCCCCCCCCEECC | 18.69 | 22369663 | |
| 109 | Phosphorylation | HTPSGSPSLKVQSGG CCCCCCCCCEECCCC | 42.38 | 22369663 | |
| 114 | Phosphorylation | SPSLKVQSGGDIKDD CCCCEECCCCCCCCC | 47.97 | 28889911 | |
| 127 | Phosphorylation | DDPKENDTTTTTNTT CCCCCCCCCCCCCCC | 37.31 | 24961812 | |
| 128 | Phosphorylation | DPKENDTTTTTNTTL CCCCCCCCCCCCCCC | 25.63 | 21440633 | |
| 129 | Phosphorylation | PKENDTTTTTNTTLQ CCCCCCCCCCCCCCH | 33.44 | 21440633 | |
| 130 | Phosphorylation | KENDTTTTTNTTLQD CCCCCCCCCCCCCHH | 18.89 | 24961812 | |
| 131 | Phosphorylation | ENDTTTTTNTTLQDR CCCCCCCCCCCCHHH | 28.60 | 24961812 | |
| 133 | Phosphorylation | DTTTTTNTTLQDRRD CCCCCCCCCCHHHHC | 27.13 | 24961812 | |
| 134 | Phosphorylation | TTTTTNTTLQDRRDS CCCCCCCCCHHHHCC | 25.21 | 20377248 | |
| 141 | Phosphorylation | TLQDRRDSDNAVHAA CCHHHHCCCCCCHHH | 30.84 | 22369663 | |
| 150 | Phosphorylation | NAVHAAASPLAPSNT CCCHHHCCCCCCCCC | 18.73 | 22369663 | |
| 155 | Phosphorylation | AASPLAPSNTPSDPK HCCCCCCCCCCCCHH | 47.96 | 22890988 | |
| 157 | Phosphorylation | SPLAPSNTPSDPKSL CCCCCCCCCCCHHHH | 28.62 | 22890988 | |
| 159 | Phosphorylation | LAPSNTPSDPKSLCN CCCCCCCCCHHHHCC | 65.59 | 22890988 | |
| 228 | Phosphorylation | PPQAPAVSSPGTTAA CCCCCCCCCCCCCCC | 32.68 | 28889911 | |
| 229 | Phosphorylation | PQAPAVSSPGTTAAG CCCCCCCCCCCCCCC | 22.28 | 21440633 | |
| 232 | Phosphorylation | PAVSSPGTTAAGSGA CCCCCCCCCCCCCCC | 19.35 | 24961812 | |
| 233 | Phosphorylation | AVSSPGTTAAGSGAG CCCCCCCCCCCCCCC | 22.04 | 21440633 | |
| 237 | Phosphorylation | PGTTAAGSGAGTGSG CCCCCCCCCCCCCCC | 22.27 | 27017623 | |
| 241 | Phosphorylation | AAGSGAGTGSGIRSR CCCCCCCCCCCCCCC | 27.86 | 24961812 | |
| 243 | Phosphorylation | GSGAGTGSGIRSRTG CCCCCCCCCCCCCCC | 30.77 | 24961812 | |
| 247 | Phosphorylation | GTGSGIRSRTGSDLP CCCCCCCCCCCCCCC | 32.07 | 28889911 | |
| 249 | Phosphorylation | GSGIRSRTGSDLPLI CCCCCCCCCCCCCEE | 42.14 | 22369663 | |
| 251 | Phosphorylation | GIRSRTGSDLPLIIT CCCCCCCCCCCEEEE | 35.05 | 22369663 | |
| 258 | Phosphorylation | SDLPLIITSANKNNG CCCCEEEEECCCCCC | 18.13 | 30377154 | |
| 259 | Phosphorylation | DLPLIITSANKNNGK CCCEEEEECCCCCCC | 21.31 | 23749301 | |
| 268 | Phosphorylation | NKNNGKTTNSPMSIL CCCCCCCCCCCCCHH | 36.87 | 19779198 | |
| 270 | Phosphorylation | NNGKTTNSPMSILSR CCCCCCCCCCCHHHC | 21.64 | 22369663 | |
| 273 | Phosphorylation | KTTNSPMSILSRNNS CCCCCCCCHHHCCCC | 24.62 | 22369663 | |
| 276 | Phosphorylation | NSPMSILSRNNSTNN CCCCCHHHCCCCCCC | 31.15 | 23749301 | |
| 280 | Phosphorylation | SILSRNNSTNNNDNN CHHHCCCCCCCCCCC | 35.74 | 23749301 | |
| 281 | Phosphorylation | ILSRNNSTNNNDNNS HHHCCCCCCCCCCCC | 44.05 | 28889911 | |
| 288 | Phosphorylation | TNNNDNNSIQSSDSR CCCCCCCCCCCCCCC | 28.41 | 28889911 | |
| 294 | Phosphorylation | NSIQSSDSRESSNNN CCCCCCCCCCCCCCC | 39.64 | 28889911 | |
| 298 | Phosphorylation | SSDSRESSNNNEIGG CCCCCCCCCCCCCCC | 38.53 | 28889911 | |
| 316 | Phosphorylation | GGTKRGGSPSNDSQV CCCCCCCCCCCCCCC | 28.16 | 22369663 | |
| 318 | Phosphorylation | TKRGGSPSNDSQVQH CCCCCCCCCCCCCCC | 55.77 | 22369663 | |
| 321 | Phosphorylation | GGSPSNDSQVQHNVH CCCCCCCCCCCCCCC | 36.18 | 22369663 | |
| 342 | Phosphorylation | GVAPRNFYFNKDREI ECCCCCEECCCCCCC | 15.14 | 19823750 | |
| 345 | Acetylation | PRNFYFNKDREITDP CCCEECCCCCCCCCC | 48.54 | 24489116 | |
| 361 | Phosphorylation | VKLDENESKINISFW CCCCCCCCCEEEEEE | 50.87 | 21440633 | |
| 396 | Phosphorylation | SSNTDTPTNSRHANT CCCCCCCCCCCCCCC | 48.17 | 27214570 | |
| 398 | Phosphorylation | NTDTPTNSRHANTSS CCCCCCCCCCCCCCC | 28.11 | 27214570 | |
| 403 | Phosphorylation | TNSRHANTSSSITSR CCCCCCCCCCCCCCC | 30.67 | 30377154 | |
| 404 | Phosphorylation | NSRHANTSSSITSRN CCCCCCCCCCCCCCC | 23.15 | 30377154 | |
| 405 | Phosphorylation | SRHANTSSSITSRNN CCCCCCCCCCCCCCC | 24.58 | 23749301 | |
| 406 | Phosphorylation | RHANTSSSITSRNNF CCCCCCCCCCCCCCC | 29.65 | 23749301 | |
| 428 | Phosphorylation | IPSQPPTSASSFTST CCCCCCCCHHHCCCC | 31.74 | 27017623 | |
| 434 | Phosphorylation | TSASSFTSTNNNNPQ CCHHHCCCCCCCCCC | 27.42 | 30377154 | |
| 459 | Phosphorylation | FATSSRPSTGFFYGD CCCCCCCCCCEECCC | 39.80 | 27214570 | |
| 475 | Phosphorylation | PNRNNRNSPFHTNEQ CCCCCCCCCCCCCCC | 26.21 | 28889911 | |
| 483 | Phosphorylation | PFHTNEQYIPPPPPK CCCCCCCCCCCCCCH | 14.82 | 28889911 | |
| 490 | Acetylation | YIPPPPPKYINSKLD CCCCCCCHHHCCCCH | 65.62 | 24489116 | |
| 495 | Acetylation | PPKYINSKLDGLRSR CCHHHCCCCHHHHHH | 46.22 | 24489116 | |
| 509 | Phosphorylation | RLLLGPNSASSSTKL HHCCCCCCCCCCCCC | 32.44 | 22369663 | |
| 511 | Phosphorylation | LLGPNSASSSTKLDD CCCCCCCCCCCCCCC | 25.33 | 22369663 | |
| 512 | Phosphorylation | LGPNSASSSTKLDDD CCCCCCCCCCCCCCC | 41.57 | 24909858 | |
| 513 | Phosphorylation | GPNSASSSTKLDDDL CCCCCCCCCCCCCCH | 27.37 | 21440633 | |
| 514 | Phosphorylation | PNSASSSTKLDDDLG CCCCCCCCCCCCCHH | 37.26 | 22369663 | |
| 522 | Phosphorylation | KLDDDLGTAAAVLSN CCCCCHHHHHHHHHH | 22.03 | 22369663 | |
| 528 | Phosphorylation | GTAAAVLSNMRSSPY HHHHHHHHHCCCCCC | 23.21 | 22369663 | |
| 532 | Phosphorylation | AVLSNMRSSPYRTHD HHHHHCCCCCCCCCC | 25.54 | 22369663 | |
| 533 | Phosphorylation | VLSNMRSSPYRTHDK HHHHCCCCCCCCCCC | 18.65 | 22369663 | |
| 535 | Phosphorylation | SNMRSSPYRTHDKPI HHCCCCCCCCCCCCC | 30.05 | 22369663 | |
| 543 | Phosphorylation | RTHDKPISNVNDMNN CCCCCCCCCCCCCCC | 43.16 | 27017623 | |
| 559 | Phosphorylation | NALGVPASRPHSSSF CCCCCCCCCCCCCCC | 40.03 | 28889911 | |
| 563 | Phosphorylation | VPASRPHSSSFPSKG CCCCCCCCCCCCCCC | 30.29 | 28889911 | |
| 564 | Phosphorylation | PASRPHSSSFPSKGV CCCCCCCCCCCCCCC | 32.72 | 28132839 | |
| 618 | Acetylation | HLNLNSKKVLDPTFE HCCCCCCCCCCCCHH | 48.10 | 24489116 | |
| 635 | Acetylation | TRQVTWNKNGKRIDR CCEEEECCCCCEEHH | 59.65 | 25381059 | |
| 645 | Phosphorylation | KRIDRRLSAPEQQQQ CEEHHHCCCHHHHHC | 39.71 | 19823750 | |
| 687 | Phosphorylation | SLGESSTSSAPSSPS CCCCCCCCCCCCCCC | 26.84 | 28889911 | |
| 688 | Phosphorylation | LGESSTSSAPSSPSL CCCCCCCCCCCCCCC | 44.26 | 19684113 | |
| 691 | Phosphorylation | SSTSSAPSSPSLKAS CCCCCCCCCCCCCCC | 55.38 | 19684113 | |
| 692 | Phosphorylation | STSSAPSSPSLKASS CCCCCCCCCCCCCCC | 19.90 | 19684113 | |
| 694 | Phosphorylation | SSAPSSPSLKASSGL CCCCCCCCCCCCCCC | 44.44 | 27017623 | |
| 711 | Phosphorylation | TADYPNATSPDFAKS CCCCCCCCCHHHHHH | 47.64 | 28132839 | |
| 712 | Phosphorylation | ADYPNATSPDFAKSK CCCCCCCCHHHHHHC | 21.77 | 21551504 | |
| 717 | Acetylation | ATSPDFAKSKGKNVK CCCHHHHHHCCCCCC | 53.33 | 24489116 | |
| 736 | Acetylation | SKAKQSSKKRPNNTT HHHHHCCCCCCCCCC | 59.03 | 22438583 | |
| 737 | Acetylation | KAKQSSKKRPNNTTS HHHHCCCCCCCCCCC | 75.04 | 22438583 | |
| 743 | Phosphorylation | KKRPNNTTSKSKANN CCCCCCCCCHHHCCC | 35.96 | 27017623 | |
| 745 | Acetylation | RPNNTTSKSKANNSQ CCCCCCCHHHCCCCC | 54.61 | 22438583 | |
| 747 | Ubiquitination | NNTTSKSKANNSQES CCCCCHHHCCCCCCC | 59.89 | 23749301 | |
| 751 | Phosphorylation | SKSKANNSQESNNAT CHHHCCCCCCCCCCC | 34.82 | 23749301 | |
| 754 | Phosphorylation | KANNSQESNNATSST HCCCCCCCCCCCCCC | 27.96 | 30377154 | |
| 760 | Phosphorylation | ESNNATSSTSQGTRS CCCCCCCCCCCCCHH | 27.94 | 28889911 | |
| 761 | Phosphorylation | SNNATSSTSQGTRSR CCCCCCCCCCCCHHH | 25.49 | 27017623 | |
| 762 | Phosphorylation | NNATSSTSQGTRSRT CCCCCCCCCCCHHHC | 28.67 | 28889911 | |
| 765 | Phosphorylation | TSSTSQGTRSRTGCW CCCCCCCCHHHCCEE | 20.17 | 27017623 | |
| 809 | Phosphorylation | AFKPDFVSDPKKKQM CCCCCCCCCHHHHHC | 48.46 | 27017623 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UME6_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UME6_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-73; SER-141;SER-150; SER-270; SER-316; SER-645 AND SER-712, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59; SER-141; SER-150 ANDSER-645, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645, AND MASSSPECTROMETRY. | |
