HMDH2_YEAST - dbPTM
HMDH2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HMDH2_YEAST
UniProt AC P12684
Protein Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Gene Name HMG2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1045
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein. Nucleus envelope.
Protein Description One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis..
Protein Sequence MSLPLKTIVHLVKPFACTARFSARYPIHVIVVAVLLSAAAYLSVTQSYLNEWKLDSNQYSTYLSIKPDELFEKCTHYYRSPVSDTWKLLSSKEAADIYTPFHYYLSTISFQSKDNSTTLPSLDDVIYSVDHTRYLLSEEPKIPTELVSENGTKWRLRNNSNFILDLHNIYRNMVKQFSNKTSEFDQFDLFIILAAYLTLFYTLCCLFNDMRKIGSKFWLSFSALSNSACALYLSLYTTHSLLKKPASLLSLVIGLPFIVVIIGFKHKVRLAAFSLQKFHRISIDKKITVSNIIYEAMFQEGAYLIRDYLFYISSFIGCAIYARHLPGLVNFCILSTFMLVFDLLLSATFYSAILSMKLEINIIHRSTVIRQTLEEDGVVPTTADIIYKDETASEPHFLRSNVAIILGKASVIGLLLLINLYVFTDKLNATILNTVYFDSTIYSLPNFINYKDIGNLSNQVIISVLPKQYYTPLKKYHQIEDSVLLIIDSVSNAIRDQFISKLLFFAFAVSISINVYLLNAAKIHTGYMNFQPQSNKIDDLVVQQKSATIEFSETRSMPASSGLETPVTAKDIIISEEIQNNECVYALSSQDEPIRPLSNLVELMEKEQLKNMNNTEVSNLVVNGKLPLYSLEKKLEDTTRAVLVRRKALSTLAESPILVSEKLPFRNYDYDRVFGACCENVIGYMPIPVGVIGPLIIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLIRSGACKIWLDSEEGQNSIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVKSVLKSDVSALVELNISKNLVGSAMAGSVGGFNAHAANLVTALFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHPTEPGANARQLARIIACAVLAGELSLCSALAAGHLVQSHMTHNRKTNKANELPQPSNKGPPCKTSALL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13AcetylationKTIVHLVKPFACTAR
HHHHHHHHCCCCCHH		40.5524489116
98PhosphorylationSKEAADIYTPFHYYL
CHHHHHCCCCCHHHH		14.6523749301
99PhosphorylationKEAADIYTPFHYYLS
HHHHHCCCCCHHHHE		21.5823749301
103PhosphorylationDIYTPFHYYLSTISF
HCCCCCHHHHEEEEE		13.3823749301
112PhosphorylationLSTISFQSKDNSTTL
HEEEEEECCCCCCCC		39.7123749301
115N-linked_GlycosylationISFQSKDNSTTLPSL
EEEECCCCCCCCCCH		45.02-
150N-linked_GlycosylationPTELVSENGTKWRLR
CHHHCCCCCCEEEEC		56.80-
158N-linked_GlycosylationGTKWRLRNNSNFILD
CCEEEECCCCCCEEE		61.96-
179N-linked_GlycosylationNMVKQFSNKTSEFDQ
HHHHHHCCCCCCCCH		53.57-
277AcetylationLAAFSLQKFHRISID
HHHHHHCCHHCCCCC		48.7224489116
428N-linked_GlycosylationYVFTDKLNATILNTV
HHHHHCCCCEECCCC		40.55-
455N-linked_GlycosylationINYKDIGNLSNQVII
CCHHHHHCCCCCCCE		40.40-
546PhosphorylationDLVVQQKSATIEFSE
CEEEECCCCEEEEEC		26.7227214570
548PhosphorylationVVQQKSATIEFSETR
EEECCCCEEEEECCC		28.2920377248
556PhosphorylationIEFSETRSMPASSGL
EEEECCCCCCCCCCC		36.2223749301
560PhosphorylationETRSMPASSGLETPV
CCCCCCCCCCCCCCC		21.0427214570
561PhosphorylationTRSMPASSGLETPVT
CCCCCCCCCCCCCCC		49.8829688323
565PhosphorylationPASSGLETPVTAKDI
CCCCCCCCCCCHHHE		28.2717330950
568PhosphorylationSGLETPVTAKDIIIS
CCCCCCCCHHHEEEE		29.2327214570
633AcetylationLPLYSLEKKLEDTTR
CCCEECHHHHCCCCH		68.8722865919
647AcetylationRAVLVRRKALSTLAE
HHHHHHHHHHHHHHC		43.0224489116
650PhosphorylationLVRRKALSTLAESPI
HHHHHHHHHHHCCCE		26.6621126336
655PhosphorylationALSTLAESPILVSEK
HHHHHHCCCEEECCC		16.1921440633
662AcetylationSPILVSEKLPFRNYD
CCEEECCCCCCCCCC		54.6924489116
662UbiquitinationSPILVSEKLPFRNYD
CCEEECCCCCCCCCC		54.6924961812
722UbiquitinationASAMRGCKAINAGGG
HHHHHCCCEEECCCC		55.9423749301
736UbiquitinationGATTVLTKDGMTRGP
CCEEEECCCCCCCCC		48.3924961812
749PhosphorylationGPVVRFPTLIRSGAC
CCEEECCCHHCCCCC		31.9127017623
844UbiquitinationSGNYCTDKKPAAINW
ECCCCCCCCCCCEEE		42.3717644757
845UbiquitinationGNYCTDKKPAAINWI
CCCCCCCCCCCEEEE		42.5717644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseHRD1Q08109
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HMDH2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HMDH2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC7_YEASTUBC7physical
11390656
HRD1_YEASTHRD1physical
11390656
UBX2_YEASTUBX2physical
16179952
CDC48_YEASTCDC48physical
16179952
UFD1_YEASTUFD1physical
16179952
HMDH1_YEASTHMG1genetic
16269340
TSC3_YEASTTSC3genetic
16269340
BFR1_YEASTBFR1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
RGP1_YEASTRGP1genetic
16269340
CHO2_YEASTCHO2genetic
16269340
PHO86_YEASTPHO86genetic
16269340
UME1_YEASTUME1physical
18467557
HMDH2_YEASTHMG2physical
18467557
HMDH1_YEASTHMG1physical
18467557
HRD1_YEASTHRD1physical
19394298
ERG6_YEASTERG6genetic
20550581
AMPL_YEASTAPE1physical
21228276
SRS2_YEASTSRS2genetic
21459050
HMDH1_YEASTHMG1genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
6PGD1_YEASTGND1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
HMDH1_YEASTHMG1genetic
23891562
CDC48_YEASTCDC48physical
11756557
ASI1_YEASTASI1genetic
25236469
ASI2_YEASTASI2genetic
25236469
ASI3_YEASTASI3genetic
25236469
UBC7_YEASTUBC7genetic
25236469
GPT1_YEASTSCT1genetic
27708008
SEA4_YEASTSEA4genetic
27708008
CSG2_YEASTCSG2genetic
27708008
GPR1_YEASTGPR1genetic
27708008
PEX19_YEASTPEX19genetic
27708008
RAD55_YEASTRAD55genetic
27708008
SND1_YEASTYDR186Cgenetic
27708008
UME6_YEASTUME6genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
AAKG_YEASTSNF4genetic
27708008
SNF6_YEASTSNF6genetic
27708008
DNPEP_YEASTAPE4genetic
27708008
ANR2_YEASTANR2genetic
27708008
FEN1_YEASTRAD27genetic
27708008
DBR1_YEASTDBR1genetic
27708008
NNK1_YEASTNNK1genetic
27708008
LST4_YEASTLST4genetic
27708008
PEX1_YEASTPEX1genetic
27708008
RT109_YEASTRTT109genetic
27708008
YL032_YEASTYLL032Cgenetic
27708008
UPS2_YEASTUPS2genetic
27708008
UPS1_YEASTUPS1genetic
27708008
ARV1_YEASTARV1genetic
27708008
HMDH1_YEASTHMG1genetic
27708008
GBLP_YEASTASC1genetic
27708008
SAP30_YEASTSAP30genetic
27708008
MKS1_YEASTMKS1genetic
27708008
IRA2_YEASTIRA2genetic
27708008
VPS21_YEASTVPS21genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
HRD1_YEASTHRD1physical
27170191
UBC7_YEASTUBC7physical
27170191
MAS5_YEASTYDJ1physical
28077573
RL32_YEASTRPL32physical
28077573
CDC48_YEASTCDC48physical
28077573
RTN1_YEASTRTN1physical
28077573
YRA1_YEASTYRA1physical
28077573
GET3_YEASTGET3physical
28077573
UBX1_YEASTSHP1physical
28077573
RL4A_YEASTRPL4Aphysical
28077573
PRS7_YEASTRPT1physical
28077573
RL4B_YEASTRPL4Bphysical
28077573
RL33A_YEASTRPL33Aphysical
28077573
RL17B_YEASTRPL17Bphysical
28077573
RL30_YEASTRPL30physical
28077573
RL36A_YEASTRPL36Aphysical
28077573
NPL4_YEASTNPL4physical
28077573
UFD1_YEASTUFD1physical
28077573
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HMDH2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-548; THR-565; THR-568AND SER-655, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-565, AND MASSSPECTROMETRY.

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