RL33A_YEAST - dbPTM
RL33A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL33A_YEAST
UniProt AC P05744
Protein Name 60S ribosomal protein L33-A {ECO:0000303|PubMed:9559554}
Gene Name RPL33A {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 107
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MAESHRLYVKGKHLSYQRSKRVNNPNVSLIKIEGVATPQDAQFYLGKRIAYVYRASKEVRGSKIRVMWGKVTRTHGNSGVVRATFRNNLPAKTFGASVRIFLYPSNI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAESHRLYV
------CCCCCEEEE		27.3110601260
4Phosphorylation----MAESHRLYVKG
----CCCCCEEEECC		12.3619823750
8PhosphorylationMAESHRLYVKGKHLS
CCCCCEEEECCCCCC		10.4819823750
10UbiquitinationESHRLYVKGKHLSYQ
CCCEEEECCCCCCCC		49.0022817900
12UbiquitinationHRLYVKGKHLSYQRS
CEEEECCCCCCCCCC		35.3423749301
12AcetylationHRLYVKGKHLSYQRS
CEEEECCCCCCCCCC		35.3424489116
15PhosphorylationYVKGKHLSYQRSKRV
EECCCCCCCCCCCCC		20.9519823750
16PhosphorylationVKGKHLSYQRSKRVN
ECCCCCCCCCCCCCC		17.8219823750
19PhosphorylationKHLSYQRSKRVNNPN
CCCCCCCCCCCCCCC		14.8619823750
20UbiquitinationHLSYQRSKRVNNPNV
CCCCCCCCCCCCCCE		63.6617644757
28PhosphorylationRVNNPNVSLIKIEGV
CCCCCCEEEEEEECC		30.9022369663
31AcetylationNPNVSLIKIEGVATP
CCCEEEEEEECCCCH		39.7424489116
31UbiquitinationNPNVSLIKIEGVATP
CCCEEEEEEECCCCH		39.7423749301
37PhosphorylationIKIEGVATPQDAQFY
EEEECCCCHHCCHHH		21.0527214570
47AcetylationDAQFYLGKRIAYVYR
CCHHHHHCEEEEEHH		37.7324489116
47SuccinylationDAQFYLGKRIAYVYR
CCHHHHHCEEEEEHH		37.7323954790
472-HydroxyisobutyrylationDAQFYLGKRIAYVYR
CCHHHHHCEEEEEHH		37.73-
47UbiquitinationDAQFYLGKRIAYVYR
CCHHHHHCEEEEEHH		37.7323749301
51PhosphorylationYLGKRIAYVYRASKE
HHHCEEEEEHHHCCH		8.8122369663
53PhosphorylationGKRIAYVYRASKEVR
HCEEEEEHHHCCHHC		6.4421440633
57UbiquitinationAYVYRASKEVRGSKI
EEEHHHCCHHCCCCE		60.2822817900
572-HydroxyisobutyrylationAYVYRASKEVRGSKI
EEEHHHCCHHCCCCE		60.28-
632-HydroxyisobutyrylationSKEVRGSKIRVMWGK
CCHHCCCCEEEEEEE		37.04-
70AcetylationKIRVMWGKVTRTHGN
CEEEEEEEEEEECCC		25.5624489116
70UbiquitinationKIRVMWGKVTRTHGN
CEEEEEEEEEEECCC		25.5623749301
78PhosphorylationVTRTHGNSGVVRATF
EEEECCCCCEEEEEE		37.2427214570
92SuccinylationFRNNLPAKTFGASVR
EECCCCCCCCCEEEE		42.3123954790
922-HydroxyisobutyrylationFRNNLPAKTFGASVR
EECCCCCCCCCEEEE		42.31-
92AcetylationFRNNLPAKTFGASVR
EECCCCCCCCCEEEE		42.3124489116
92UbiquitinationFRNNLPAKTFGASVR
EECCCCCCCCCEEEE		42.3123749301
93PhosphorylationRNNLPAKTFGASVRI
ECCCCCCCCCEEEEE		29.4328889911
97PhosphorylationPAKTFGASVRIFLYP
CCCCCCEEEEEEECC		16.5921440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL33A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RL33A_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL33A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RL33B_YEASTRPL33Bgenetic
22377630
PESC_YEASTNOP7genetic
17548477
DRS1_YEASTDRS1genetic
17548477
CND2_YEASTBRN1genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
SED5_YEASTSED5genetic
27708008
MCM1_YEASTMCM1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
RL35A_YEASTRPL35Agenetic
27708008
RL35B_YEASTRPL35Agenetic
27708008
SUM1_YEASTSUM1genetic
27708008
UPF3_YEASTUPF3genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
CTK1_YEASTCTK1genetic
27708008
RS29A_YEASTRPS29Agenetic
27708008
TSR2_YEASTTSR2genetic
27708008
NAM7_YEASTNAM7genetic
27708008
MUB1_YEASTMUB1genetic
27708008
2A5D_YEASTRTS1genetic
27708008
ORC2_YEASTORC2genetic
27708008
TECR_YEASTTSC13genetic
27708008
SNU23_YEASTSNU23genetic
27708008
DBF4_YEASTDBF4genetic
27708008
MAK21_YEASTMAK21genetic
27708008
MSS4_YEASTMSS4genetic
27708008
RMRP_YEASTSNM1genetic
27708008
PSB3_YEASTPUP3genetic
27708008
SP105_YEASTSPC105genetic
27708008
SWC4_YEASTSWC4genetic
27708008
TEL2_YEASTTEL2genetic
27708008
CP51_YEASTERG11genetic
27708008
MED6_YEASTMED6genetic
27708008
GRP78_YEASTKAR2genetic
27708008
NOP56_YEASTNOP56genetic
27708008
SEC22_YEASTSEC22genetic
27708008
DBP9_YEASTDBP9genetic
27708008
DPOA_YEASTPOL1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
PRP4_YEASTPRP4genetic
27708008
SHE1_YEASTSHE1genetic
27708008
UBC4_YEASTUBC4genetic
27708008
RPN4_YEASTRPN4genetic
27708008
VAM6_YEASTVAM6genetic
27708008
PAA1_YEASTPAA1genetic
27708008
UME6_YEASTUME6genetic
27708008
RIM15_YEASTRIM15genetic
27708008
UBP6_YEASTUBP6genetic
27708008
RMD8_YEASTRMD8genetic
27708008
MRM2_YEASTMRM2genetic
27708008
CHO2_YEASTCHO2genetic
27708008
SSF1_YEASTSSF1genetic
27708008
VPS35_YEASTVPS35genetic
27708008
VPS24_YEASTVPS24genetic
27708008
TCTP_YEASTTMA19genetic
27708008
DOA1_YEASTDOA1genetic
27708008
HBS1_YEASTHBS1genetic
27708008
FPS1_YEASTFPS1genetic
27708008
ERG3_YEASTERG3genetic
27708008
SRR1L_YEASTBER1genetic
27708008
YPT7_YEASTYPT7genetic
27708008
GBLP_YEASTASC1genetic
27708008
PKR1_YEASTPKR1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
DOM34_YEASTDOM34genetic
27708008
SFL1_YEASTSFL1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL33A_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"The action of N-terminal acetyltransferases on yeast ribosomalproteins.";
Arnold R.J., Polevoda B., Reilly J.P., Sherman F.;
J. Biol. Chem. 274:37035-37040(1999).
Cited for: CLEAVAGE OF INITIATOR METHIONINE, AND PARTIAL ACETYLATION AT ALA-2 BYNATA.

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