SHE1_YEAST - dbPTM
SHE1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SHE1_YEAST
UniProt AC P38200
Protein Name Mitotic spindle-associated protein SHE1
Gene Name SHE1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 338
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Bud neck.
Protein Description May have a role related to the spindle integrity function of the DAM1 complex, which is essential for proper chromosome segregation. Causes growth arrest when highly overexpressed..
Protein Sequence MNDKLQEEHNEKDTTSQINGFTPPHMSIDFHSNNNSNIIETIGVSKRLGNSVLSELDSRASSKFEFLKDQSEQQYNGDKNNEPKSGSYNINEFFQAKHDSQFGQMESLDTHYTLLHTPKRKSQHAIPQDRSDSMKRSRPSRSIPYTTPVVNDITRRIRRLKLRNSLVNGNDIVARARSMQANSNINSIKNTPLSKPKPFMHKPNFLMPTTNSLNKINSAHRNTSSSSTASSIPRSKVHRSISIRDLHAKTKPVERTPVAQGTNSQLKNSVSVFDRLYKQTTFSRSTSMNNLSSGTSAKSKEHTNVKTRLVKSKTSGSLSSNLKQSTATGTKSDRPIWR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51PhosphorylationVSKRLGNSVLSELDS
CHHHHCCHHHHHHHH		23.7230377154
63AcetylationLDSRASSKFEFLKDQ
HHHHHHHHHHHHHHH		46.5522865919
112PhosphorylationMESLDTHYTLLHTPK
CCCCCHHHHEECCCC		10.9421440633
113PhosphorylationESLDTHYTLLHTPKR
CCCCHHHHEECCCCC		18.4219779198
117PhosphorylationTHYTLLHTPKRKSQH
HHHHEECCCCCCCCC		30.4024961812
131PhosphorylationHAIPQDRSDSMKRSR
CCCCCCCCHHHHHCC		42.1821082442
133PhosphorylationIPQDRSDSMKRSRPS
CCCCCCHHHHHCCCC		27.7021440633
165PhosphorylationRRLKLRNSLVNGNDI
HHHHHHHHHCCCCHH		27.5321082442
218PhosphorylationNSLNKINSAHRNTSS
CCHHHHHHHCCCCCC		29.0021440633
224PhosphorylationNSAHRNTSSSSTASS
HHHCCCCCCCCCCCC		31.6027017623
231PhosphorylationSSSSTASSIPRSKVH
CCCCCCCCCCHHHCC		33.8627017623
242PhosphorylationSKVHRSISIRDLHAK
HHCCCCCCHHHHCCC		16.9017287358
256PhosphorylationKTKPVERTPVAQGTN
CCCCCCCCCCCCCCC		14.4921440633
264PhosphorylationPVAQGTNSQLKNSVS
CCCCCCCHHHHHHHH		36.4130377154
271PhosphorylationSQLKNSVSVFDRLYK
HHHHHHHHHHHHHHH		19.5221440633
281PhosphorylationDRLYKQTTFSRSTSM
HHHHHHCCCCCCCCC		19.6721440633
283PhosphorylationLYKQTTFSRSTSMNN
HHHHCCCCCCCCCCC		24.1923749301
285PhosphorylationKQTTFSRSTSMNNLS
HHCCCCCCCCCCCCC		24.5222369663
286PhosphorylationQTTFSRSTSMNNLSS
HCCCCCCCCCCCCCC		30.7722369663
287PhosphorylationTTFSRSTSMNNLSSG
CCCCCCCCCCCCCCC		22.2822369663
292PhosphorylationSTSMNNLSSGTSAKS
CCCCCCCCCCCCCCC		28.9222369663
293PhosphorylationTSMNNLSSGTSAKSK
CCCCCCCCCCCCCCH		49.6222369663
295PhosphorylationMNNLSSGTSAKSKEH
CCCCCCCCCCCCHHC		27.7122369663
296PhosphorylationNNLSSGTSAKSKEHT
CCCCCCCCCCCHHCC		36.9122369663
312PhosphorylationVKTRLVKSKTSGSLS
CCHHHEEECCCCCCC		33.4222369663
314PhosphorylationTRLVKSKTSGSLSSN
HHHEEECCCCCCCCC		45.4722369663
315PhosphorylationRLVKSKTSGSLSSNL
HHEEECCCCCCCCCC		30.0722369663
317PhosphorylationVKSKTSGSLSSNLKQ
EEECCCCCCCCCCHH		25.5022369663
319PhosphorylationSKTSGSLSSNLKQST
ECCCCCCCCCCHHCC		20.9122369663
320PhosphorylationKTSGSLSSNLKQSTA
CCCCCCCCCCHHCCC		52.0222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SHE1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SHE1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SHE1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DYHC_YEASTDYN1genetic
19403691
BDH1_YEASTBDH1genetic
20093466
LTE1_YEASTLTE1genetic
20093466
MDM10_YEASTMDM10genetic
20093466
SWC5_YEASTSWC5genetic
20093466
RMD9L_YEASTYBR238Cgenetic
20093466
HCM1_YEASTHCM1genetic
20093466
DHE2_YEASTGDH2genetic
20093466
UME6_YEASTUME6genetic
20093466
SWM1_YEASTSWM1genetic
20093466
RT103_YEASTRTT103genetic
20093466
OMS1_YEASTOMS1genetic
20093466
EAF1_YEASTEAF1genetic
20093466
EMI2_YEASTEMI2genetic
20093466
KIP3_YEASTKIP3genetic
20093466
CLG1_YEASTCLG1genetic
20093466
CGR1_YEASTCGR1genetic
20093466
DBF2_YEASTDBF2genetic
20093466
ASK10_YEASTASK10genetic
20093466
TIM13_YEASTTIM13genetic
20093466
G3P3_YEASTTDH3genetic
20093466
TOS2_YEASTTOS2genetic
20093466
OPI1_YEASTOPI1genetic
20093466
YIT6_YEASTYIR016Wgenetic
20093466
UPS1_YEASTUPS1genetic
20093466
RSC2_YEASTRSC2genetic
20093466
SLK19_YEASTSLK19genetic
20093466
MCM21_YEASTMCM21physical
21079246
TBA1_YEASTTUB1physical
23142046
TBB_YEASTTUB2physical
23142046
CDC24_YEASTCDC24genetic
27708008
SWC4_YEASTSWC4genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CLP1_YEASTCLP1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
APC11_YEASTAPC11genetic
27708008
TECR_YEASTTSC13genetic
27708008
NOP14_YEASTNOP14genetic
27708008
SNU56_YEASTSNU56genetic
27708008
UTP5_YEASTUTP5genetic
27708008
ACT_YEASTACT1genetic
27708008
RPN11_YEASTRPN11genetic
27708008
CDC14_YEASTCDC14genetic
27708008
CDC20_YEASTCDC20genetic
27708008
GPI10_YEASTGPI10genetic
27708008
SMD1_YEASTSMD1genetic
27708008
XPO1_YEASTCRM1genetic
27708008
MED6_YEASTMED6genetic
27708008
CDC23_YEASTCDC23genetic
27708008
SPC97_YEASTSPC97genetic
27708008
STS1_YEASTSTS1genetic
27708008
ESS1_YEASTESS1genetic
27708008
FNTA_YEASTRAM2genetic
27708008
MIF2_YEASTMIF2genetic
27708008
ABF1_YEASTABF1genetic
27708008
PRS7_YEASTRPT1genetic
27708008
SN114_YEASTSNU114genetic
27708008
PRP19_YEASTPRP19genetic
27708008
STU2_YEASTSTU2genetic
27708008
SMC4_YEASTSMC4genetic
27708008
GSP1_YEASTGSP1genetic
27708008
IMB1_YEASTKAP95genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
RNA1_YEASTRNA1genetic
27708008
RPC6_YEASTRPC34genetic
27708008
DBP6_YEASTDBP6genetic
27708008
NUF2_YEASTNUF2genetic
27708008
TYSY_YEASTCDC21genetic
27708008
APC5_YEASTAPC5genetic
27708008
PSA7_YEASTPRE10genetic
27708008
GPI2_YEASTGPI2genetic
27708008
TBF1_YEASTTBF1genetic
27708008
HRR25_YEASTHRR25genetic
27708008
IPL1_YEASTIPL1genetic
27708008
DIM1_YEASTDIM1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
MDM10_YEASTMDM10genetic
27708008
BDH1_YEASTBDH1genetic
27708008
UME6_YEASTUME6genetic
27708008
RT103_YEASTRTT103genetic
27708008
VAM7_YEASTVAM7genetic
27708008
CLG1_YEASTCLG1genetic
27708008
KIP3_YEASTKIP3genetic
27708008
DBF2_YEASTDBF2genetic
27708008
TIM13_YEASTTIM13genetic
27708008
TOS2_YEASTTOS2genetic
27708008
OPI1_YEASTOPI1genetic
27708008
MOG1_YEASTMOG1genetic
27708008
SLK19_YEASTSLK19genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SHE1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242, AND MASSSPECTROMETRY.

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