UniProt ID | IMB1_YEAST | |
---|---|---|
UniProt AC | Q06142 | |
Protein Name | Importin subunit beta-1 {ECO:0000303|PubMed:9321403} | |
Gene Name | KAP95 {ECO:0000303|PubMed:7622450} | |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
Sequence Length | 861 | |
Subcellular Localization | Cytoplasm . Nucleus . Nucleus, nuclear pore complex . | |
Protein Description | Importin beta subunit that functions in nuclear protein import through association with the importin alpha subunit, which binds to the classical nuclear localization signal (cNLS) in cargo substrates. [PubMed: 7622450 Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by importin beta through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism] | |
Protein Sequence | MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKRQLSL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MSTAEFAQL ------CCHHHHHHH | 36.00 | 22814378 | |
30 | 2-Hydroxyisobutyrylation | LTSETQLKKLSNDNF CCCHHHHHHHCCCCC | 41.68 | - | |
30 | Ubiquitination | LTSETQLKKLSNDNF CCCHHHHHHHCCCCC | 41.68 | 17644757 | |
31 | Ubiquitination | TSETQLKKLSNDNFL CCHHHHHHHCCCCCH | 66.78 | 17644757 | |
54 | Ubiquitination | VLIDENTKLEGRILA EEECCCCCCCHHHHH | 57.00 | 17644757 | |
74 | Phosphorylation | NELVSKDSVKTQQFA CCCCCCCHHHHHHHH | 29.29 | 19823750 | |
76 | Ubiquitination | LVSKDSVKTQQFAQR CCCCCHHHHHHHHHH | 44.56 | 23749301 | |
77 | Phosphorylation | VSKDSVKTQQFAQRW CCCCHHHHHHHHHHH | 26.00 | 19823750 | |
86 | Phosphorylation | QFAQRWITQVSPEAK HHHHHHHHHCCHHHH | 18.89 | 19823750 | |
89 | Phosphorylation | QRWITQVSPEAKNQI HHHHHHCCHHHHHHH | 13.75 | 19779198 | |
93 | Ubiquitination | TQVSPEAKNQIKTNA HHCCHHHHHHHCCCH | 47.96 | 23749301 | |
106 | Phosphorylation | NALTALVSIEPRIAN CHHHHHHHCCHHHHH | 23.29 | 19779198 | |
152 | Ubiquitination | AEQPENVKRASLLAL CCCCCHHHHHHHHHH | 54.55 | 23749301 | |
213 | Ubiquitination | ADSLIFIKNNMEREG HHHHHHHCCCCCCCC | 31.36 | 23749301 | |
262 | Phosphorylation | YYTFMKPYMEQALYA HHHHHHHHHHHHHHH | 14.04 | 27017623 | |
268 | Phosphorylation | PYMEQALYALTIATM HHHHHHHHHHHHHHC | 11.55 | 27017623 | |
271 | Phosphorylation | EQALYALTIATMKSP HHHHHHHHHHHCCCC | 10.61 | 27017623 | |
415 | Phosphorylation | YVHQALPSILNLMND HHHHHHHHHHHHCCC | 40.32 | 24909858 | |
424 | Phosphorylation | LNLMNDQSLQVKETT HHHCCCCCCCCHHHH | 24.51 | 24909858 | |
468 | Ubiquitination | IGLQDHPKVATNCSW HCCCCCHHHHHHCHH | 40.87 | 17644757 | |
817 | Phosphorylation | AAMFPDGSIKQFYGQ HHHCCCCCHHHHHCC | 33.71 | 27017623 | |
834 | Phosphorylation | VIDYIKRTRSGQLFS HHHHHHHHCCCCCCC | 24.96 | 21440633 | |
836 | Phosphorylation | DYIKRTRSGQLFSQA HHHHHHCCCCCCCHH | 30.22 | 25752575 | |
845 | Ubiquitination | QLFSQATKDTARWAR CCCCHHHHHHHHHHH | 56.98 | 23749301 | |
845 | Acetylation | QLFSQATKDTARWAR CCCCHHHHHHHHHHH | 56.98 | 24489116 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IMB1_YEAST !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IMB1_YEAST !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IMB1_YEAST !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-836, AND MASSSPECTROMETRY. |