SLS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLS1_YEAST
• UniProt AC: P42900
• Protein Name: Sigma-like sequence protein 1, mitochondrial
• Gene Name: SLS1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 643
• Subcellular Localization: Mitochondrion inner membrane .
• Protein Description: Involved in aerobic respiration where it is required for assembly of respiratory chain enzyme complexes III and IV. Also has a role in mitochondrial gene expression. May be part of a mitochondrial membrane-associated RNA-shuttling system, delivering NAM1-associated transcripts to the translation machinery..
• Protein Sequence: MWKFNKKLARLTYRLYSSSGPSSPLHGKKKLPQNLKFVVLNPTQSGLVKNDQKQPRHRPSKKRSHKETGDNNLDFGSKLLVFEKQNSLDSALNSIRLKKPTSASLPSLEYNALLQSLTSSYNRYQLREFISTHQPDSSSHLTHWKKSKLSQYIIEKIWNCQPISTPTTPTGIKSTSLTFQFDSPREIFLLLITQNGKILTNFNKLGLTFIISIQDNELTVKGSPSLLKYAEISLNKIWSNITHENVRMYSLMPSKDVINLIQKETHTFFEYLPDLQMYKISALSTKKISMAKVFLLNAVASNPNTTQHHHTIASPALKTELYPFNNTLENLDWLNKSQDWARLQSVVPKNCTDLMTPTENATPELTDAQVSQFESSLSKNIPSLSPSDSISQSLSITLGHSLQSASFSSIFQPLIHKSFISKLLNLPMYKESSSSAVPVPVPLDQHLITNAHQSFIQLNFTPVPPTSGSSSSPFLQIWFEIDEFDNIVTTSMRPLLKLQENSVILRTPQCQTDYKITSDYIQDLLPDFDQTNPDAWLSEQKGLQEFLLKSHWKLNKYQNLMKKINISLPDNLIQQYQLTDVLTHRVLNLRFPTNTAQDDKYIIQYSDISRGFLNNGSYRQLDFINVNPSETSLKTFINDVLSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	KFVVLNPTQSGLVKN EEEEECCCCCCCCCC	34.00	30377154
45	Phosphorylation	VVLNPTQSGLVKNDQ EEECCCCCCCCCCCC	36.25	30377154
281	Phosphorylation	DLQMYKISALSTKKI CCCCCEEECCCCCCC	21.00	30377154
284	Phosphorylation	MYKISALSTKKISMA CCEEECCCCCCCCHH	37.59	22369663
285	Phosphorylation	YKISALSTKKISMAK CEEECCCCCCCCHHH	36.89	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLS1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTF2_YEAST	MTF2	physical	16429126
URB1_YEAST	URB1	genetic	19061648
IF2M_YEAST	IFM1	genetic	19061648
SRS2_YEAST	SRS2	genetic	21459050
RRP5_YEAST	RRP5	physical	22940862
HAS1_YEAST	HAS1	physical	22940862
DED1_YEAST	DED1	physical	22940862
SSB1_YEAST	SSB1	physical	22940862
SLS1_YEAST	SLS1	physical	22940862
RL4B_YEAST	RPL4B	physical	22940862
RL4A_YEAST	RPL4A	physical	22940862
MTF2_YEAST	MTF2	physical	22940862
HSP71_YEAST	SSA1	physical	22940862
PABP_YEAST	PAB1	physical	22940862
ATPB_YEAST	ATP2	genetic	27811238

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.