| UniProt ID | URB1_YEAST | |
|---|---|---|
| UniProt AC | P34241 | |
| Protein Name | Nucleolar pre-ribosomal-associated protein 1 | |
| Gene Name | URB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1764 | |
| Subcellular Localization | Nucleus, nucleolus . Accumulates in the immediate vicinity of the dense fibrillar component of the nucleolus. | |
| Protein Description | Required for 60S ribosomal subunit formation and pre-rRNA processing. Required for normal accumulation of 25S and 5.8S rRNAs.. | |
| Protein Sequence | MSNHSEAYGSRDQRREKYTQGKEFEDGTLETLESIISAVEDETLSKDYQPLIVFFQRGFGAQLVQTWSYYAQVNNHGKFSKTTSLLTKTLRVLSSDTSTVTIGSGLIRLILTDYTKVLYRGLNNMRAQLTNPILRLLKQIVNFNNGQHIEELVSYFDFSLPILPRLLVPSKSELANGNSSADSSKHDSLRFTFIKFWLTLISNASPFVRKELLTENFKIMSNLFKFMNKADSDKLSEHILSVFINDILKEKSFKRTTKTKILNELAASKIHHFYYSSNKNLVKKANEFFLTFGASRDFSVAFPDNCVWFKNSVADGASHGAPITVNQVEFQIHNKLLFNTLRLFKPWEDTLQLGTLIKILENVPELVAPYSIFLTTNGNYDPKMTSYWFGITLLINKIINLKIPQFMEKVDSNIPPATSLVIENILPSLLTKSSLVKSLQFETPIIRQLACQSIVLALKKLEKVSTFYDQKGWRNEKTILLNEFHTRIPDLPIFVSTLSNSLASNKDNRILPLSISIIFNYYSKMFPNLFSINLPSSNIYTDIMQKSKISGIEFAILDNYLQFQEFNSTQTRWWNPSSGGNSLFTLLLKLASSKNASNVITTRISNLLDELTRTNVIFNISLISPVMALVNSLQGLSLQVSEIDNMEQVWKWFDETISRVVKTPYKYVDMAKEYNYISPFIMCLSEQWKYVDKSGNPEFLIKWLILFLRNMIFIGEDHIGIDKLVKNVFPEVSDHDVNIYLKLDSFEENIKKTNSSNSLISSMKSSSFFQYISALPSKNLMNISRLPVNKLDAAGILFRVQLLVEDDSVVYDNWFEATACELTGKIASYMVTDTEFPIIKVLERYINFALPKLAIEKRNALLMKKSRFMCNLIGAVCFETGHQLVEFREIIQKVVFSGENVEEYANYNELYQKEDVNAFLTSVSEYLSTSALTSLLMCSTKLESTRNILQKLFNEGKTIKISLVKNILNKAANEDPASIKEVNISLAKFFEENKVCVDASSDPMGKLSLSETTSLINSFVSSDLNYLVLKAFYRWEHFSFPSFIPSIWRIKDSPLLSIVTTAALFKHMQDKDFSAFAHETISKYGNEIAKSTYTTSKSEIFDEILNMITTYIDFYDETKRNEILKCVLSQSDHKYHAATVRYIAAHNNFTYPGVETWLHKTLLYLTKYLSERKVISNSFFELLRAMAELLKLEEVPNKLNVKIINSQLEAILGSEWIKQIKVLEYVIVLIFCVSKKSIQSQRMVQLLLSNDSYSSIMIKDNDEDSSYRKFLSTMILFSLFSIDPVVNSTPIVQEKLLTFYSGTISSNDKLILKILETIESHTATSWTNMIFSWEFIKDEEEEILEAIGDTRLITKEREGLILTLQKNMIKKSIDRYVLERPQVPELYTDSNTNNYDATTRCDLVKKYYDDTERSGVDMYDPLFLLLLIIHNKELVKMVKDDEGNVTYRYEFENFLDCKIFQFIICSLSDCHTVANISYEHLSNLASSLEKKTAQMNLEKQITSKDNERKESDSDLIKYNSIYQVLIKRILYQRQQNQDPINPLIWFSISRIVDLLGSPTAPLHEKAYRWVLSNSTIRSWDIPMVSDVMMSYNKRQQDDNKKEIDMEIYYGELSWVLTTICKGIKTDEDYKMLEKKGVFEWLLNLINMPYLKERLRELIYFIFYKVQRVADDGGLNLISRNGIVSFFEVLNNNIKSRLPQDDILNNIGTLRNENRGTLNTTLRLAQEQNGIEKLLLGYNELVKSQKRLILWTEGDSDNVVKRLRK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MSNHSEAYGSRD ---CCCCHHHCCCHH | 28.33 | 30377154 | |
| 8 | Phosphorylation | MSNHSEAYGSRDQRR CCCCHHHCCCHHHHH | 16.16 | 30377154 | |
| 10 | Phosphorylation | NHSEAYGSRDQRREK CCHHHCCCHHHHHHH | 21.73 | 30377154 | |
| 18 | Phosphorylation | RDQRREKYTQGKEFE HHHHHHHHHCCCCCC | 10.27 | 23749301 | |
| 19 | Phosphorylation | DQRREKYTQGKEFED HHHHHHHHCCCCCCC | 41.74 | 23749301 | |
| 22 | Ubiquitination | REKYTQGKEFEDGTL HHHHHCCCCCCCCHH | 49.79 | 23749301 | |
| 179 | Phosphorylation | SELANGNSSADSSKH HHHCCCCCCCCCCCC | 28.44 | 30377154 | |
| 180 | Phosphorylation | ELANGNSSADSSKHD HHCCCCCCCCCCCCH | 39.84 | 28889911 | |
| 183 | Phosphorylation | NGNSSADSSKHDSLR CCCCCCCCCCCHHHH | 40.79 | 24930733 | |
| 268 | Phosphorylation | ILNELAASKIHHFYY HHHHHHHHHCCEEHH | 26.91 | 28889911 | |
| 277 | Phosphorylation | IHHFYYSSNKNLVKK CCEEHHCCCHHHHHH | 35.38 | 25882841 | |
| 386 | Phosphorylation | NYDPKMTSYWFGITL CCCCCCCCHHHHHHH | 19.50 | 28889911 | |
| 471 | Acetylation | VSTFYDQKGWRNEKT HCCCCCCCCCCCCEE | 58.50 | 24489116 | |
| 514 | Phosphorylation | DNRILPLSISIIFNY CCCEECCHHHHHHHH | 16.61 | 28889911 | |
| 516 | Phosphorylation | RILPLSISIIFNYYS CEECCHHHHHHHHHH | 13.27 | 28889911 | |
| 521 | Phosphorylation | SISIIFNYYSKMFPN HHHHHHHHHHHHCCC | 9.81 | 28889911 | |
| 522 | Phosphorylation | ISIIFNYYSKMFPNL HHHHHHHHHHHCCCC | 11.70 | 28889911 | |
| 523 | Phosphorylation | SIIFNYYSKMFPNLF HHHHHHHHHHCCCCE | 13.79 | 28889911 | |
| 594 | Ubiquitination | LLKLASSKNASNVIT HHHHHCCCCCCHHHH | 54.78 | 23749301 | |
| 666 | Acetylation | RVVKTPYKYVDMAKE HHCCCCHHHHHHHHH | 39.75 | 24489116 | |
| 753 | Phosphorylation | FEENIKKTNSSNSLI HHHHHHHCCCCCCHH | 35.02 | 19823750 | |
| 755 | Phosphorylation | ENIKKTNSSNSLISS HHHHHCCCCCCHHHH | 35.81 | 19823750 | |
| 756 | Phosphorylation | NIKKTNSSNSLISSM HHHHCCCCCCHHHHH | 32.29 | 19823750 | |
| 758 | Phosphorylation | KKTNSSNSLISSMKS HHCCCCCCHHHHHCC | 29.09 | 19823750 | |
| 761 | Phosphorylation | NSSNSLISSMKSSSF CCCCCHHHHHCCCCH | 29.67 | 19823750 | |
| 762 | Phosphorylation | SSNSLISSMKSSSFF CCCCHHHHHCCCCHH | 24.20 | 19823750 | |
| 765 | Phosphorylation | SLISSMKSSSFFQYI CHHHHHCCCCHHHHH | 23.67 | 30377154 | |
| 784 | Phosphorylation | SKNLMNISRLPVNKL CCCCCCCCCCCCCHH | 23.82 | 30377154 | |
| 790 | Acetylation | ISRLPVNKLDAAGIL CCCCCCCHHHHCCEE | 48.23 | 24489116 | |
| 829 | Phosphorylation | LTGKIASYMVTDTEF HHHCEEEEECCCCCC | 6.13 | 28889911 | |
| 951 | Acetylation | STRNILQKLFNEGKT HHHHHHHHHHHCCCC | 52.15 | 24489116 | |
| 1071 | Acetylation | LFKHMQDKDFSAFAH HHHHHCCCCHHHHHH | 43.72 | 24489116 | |
| 1237 | Phosphorylation | IFCVSKKSIQSQRMV HHHCCHHHHCCHHHH | 29.60 | 29136822 | |
| 1240 | Phosphorylation | VSKKSIQSQRMVQLL CCHHHHCCHHHHHHH | 20.34 | 29136822 | |
| 1249 | Phosphorylation | RMVQLLLSNDSYSSI HHHHHHHCCCCCCCE | 38.26 | 29136822 | |
| 1252 | Phosphorylation | QLLLSNDSYSSIMIK HHHHCCCCCCCEEEE | 31.03 | 29136822 | |
| 1253 | Phosphorylation | LLLSNDSYSSIMIKD HHHCCCCCCCEEEEC | 14.86 | 29136822 | |
| 1254 | Phosphorylation | LLSNDSYSSIMIKDN HHCCCCCCCEEEECC | 19.83 | 29136822 | |
| 1255 | Phosphorylation | LSNDSYSSIMIKDND HCCCCCCCEEEECCC | 14.14 | 29136822 | |
| 1265 | Phosphorylation | IKDNDEDSSYRKFLS EECCCCCHHHHHHHH | 27.50 | 26447709 | |
| 1266 | Phosphorylation | KDNDEDSSYRKFLST ECCCCCHHHHHHHHH | 41.08 | 26447709 | |
| 1267 | Phosphorylation | DNDEDSSYRKFLSTM CCCCCHHHHHHHHHH | 23.05 | 26447709 | |
| 1273 | Phosphorylation | SYRKFLSTMILFSLF HHHHHHHHHHHHHHH | 15.46 | 27017623 | |
| 1278 | Phosphorylation | LSTMILFSLFSIDPV HHHHHHHHHHCCCCC | 25.67 | 27017623 | |
| 1281 | Phosphorylation | MILFSLFSIDPVVNS HHHHHHHCCCCCCCC | 31.23 | 27017623 | |
| 1288 | Phosphorylation | SIDPVVNSTPIVQEK CCCCCCCCCHHHHHH | 24.77 | 27017623 | |
| 1504 | Acetylation | LEKQITSKDNERKES HHHHHCCCCCCCCCC | 56.79 | 25381059 | |
| 1511 | Phosphorylation | KDNERKESDSDLIKY CCCCCCCCHHHHHHH | 45.51 | 30377154 | |
| 1565 | Acetylation | PTAPLHEKAYRWVLS CCCCHHHHHHHHHHC | 39.71 | 24489116 | |
| 1755 | Phosphorylation | ILWTEGDSDNVVKRL EEECCCCCCHHHHHH | 41.77 | 21551504 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of URB1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of URB1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of URB1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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