| UniProt ID | NOP58_YEAST | |
|---|---|---|
| UniProt AC | Q12499 | |
| Protein Name | Nucleolar protein 58 | |
| Gene Name | NOP58 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 511 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Required for pre-18S rRNA processing. May bind microtubules.. | |
| Protein Sequence | MAYVLTETSAGYALLKASDKKIYKSSSLIQDLDSSDKVLKEFKIAAFSKFNSAANALEEANSIIEGKVSSQLEKLLEEIKKDKKSTLIVSETKLANAINKLGLNFNVVSDAVTLDIYRAIKEYLPELLPGMSDNDLSKMSLGLAHSIGRHKLKFSADKVDVMIIQAIALLDDLDKELNTYAMRCKEWYGWHFPELAKIVTDSVAYARIILTMGIRSKASETDLSEILPEEIEERVKTAAEVSMGTEITQTDLDNINALAEQIVEFAAYREQLSNYLSARMKAIAPNLTQLVGELVGARLIAHSGSLISLAKSPASTIQILGAEKALFRALKTKHDTPKYGLLYHASLVGQATGKNKGKIARVLAAKAAVSLRYDALAEDRDDSGDIGLESRAKVENRLSQLEGRDLRTTPKVVREAKKVEMTEARAYNADADTAKAASDSESDSDDEEEEKKEKKEKKRKRDDDEDSKDSKKAKKEKKDKKEKKEKKEKKEKKEKKEKKEKKSKKEKKEKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MAYVLTETSA -----CCEEEECCHH | 8.49 | 28889911 | |
| 6 | Phosphorylation | --MAYVLTETSAGYA --CCEEEECCHHHHH | 27.46 | 28889911 | |
| 8 | Phosphorylation | MAYVLTETSAGYALL CCEEEECCHHHHHHH | 20.74 | 28889911 | |
| 12 | Phosphorylation | LTETSAGYALLKASD EECCHHHHHHHHHCC | 8.19 | 27017623 | |
| 24 | Acetylation | ASDKKIYKSSSLIQD HCCCCHHHCCCCHHC | 47.54 | 24489116 | |
| 24 | Ubiquitination | ASDKKIYKSSSLIQD HCCCCHHHCCCCHHC | 47.54 | 17644757 | |
| 25 | Phosphorylation | SDKKIYKSSSLIQDL CCCCHHHCCCCHHCC | 14.26 | 29136822 | |
| 26 | Phosphorylation | DKKIYKSSSLIQDLD CCCHHHCCCCHHCCC | 25.63 | 21551504 | |
| 27 | Phosphorylation | KKIYKSSSLIQDLDS CCHHHCCCCHHCCCC | 36.26 | 29136822 | |
| 34 | Phosphorylation | SLIQDLDSSDKVLKE CCHHCCCCCHHHHHH | 47.97 | 21551504 | |
| 37 | Ubiquitination | QDLDSSDKVLKEFKI HCCCCCHHHHHHHHH | 51.95 | 17644757 | |
| 37 | Acetylation | QDLDSSDKVLKEFKI HCCCCCHHHHHHHHH | 51.95 | 24489116 | |
| 40 | Acetylation | DSSDKVLKEFKIAAF CCCHHHHHHHHHHHH | 65.18 | 24489116 | |
| 43 | Acetylation | DKVLKEFKIAAFSKF HHHHHHHHHHHHHHH | 32.31 | 24489116 | |
| 49 | Ubiquitination | FKIAAFSKFNSAANA HHHHHHHHHHHHHHH | 41.95 | 17644757 | |
| 49 | Acetylation | FKIAAFSKFNSAANA HHHHHHHHHHHHHHH | 41.95 | 24489116 | |
| 67 | Ubiquitination | ANSIIEGKVSSQLEK HHHHHCCHHHHHHHH | 26.59 | 17644757 | |
| 69 | Phosphorylation | SIIEGKVSSQLEKLL HHHCCHHHHHHHHHH | 18.82 | 21440633 | |
| 70 | Phosphorylation | IIEGKVSSQLEKLLE HHCCHHHHHHHHHHH | 41.60 | 27214570 | |
| 74 | Acetylation | KVSSQLEKLLEEIKK HHHHHHHHHHHHHHC | 67.95 | 24489116 | |
| 80 | Succinylation | EKLLEEIKKDKKSTL HHHHHHHHCCCCCEE | 59.19 | 23954790 | |
| 93 | Acetylation | TLIVSETKLANAINK EEEECHHHHHHHHHH | 41.36 | 24489116 | |
| 100 | Ubiquitination | KLANAINKLGLNFNV HHHHHHHHCCCCCCC | 37.51 | 17644757 | |
| 121 | Acetylation | LDIYRAIKEYLPELL HHHHHHHHHHHHHHC | 39.04 | 24489116 | |
| 132 | Phosphorylation | PELLPGMSDNDLSKM HHHCCCCCHHHHHHH | 38.89 | 27214570 | |
| 179 | Phosphorylation | DLDKELNTYAMRCKE HHHHHHHHHHHHHHH | 25.86 | 24909858 | |
| 180 | Phosphorylation | LDKELNTYAMRCKEW HHHHHHHHHHHHHHH | 9.42 | 24909858 | |
| 185 | Ubiquitination | NTYAMRCKEWYGWHF HHHHHHHHHHHCCCC | 40.70 | 17644757 | |
| 197 | Ubiquitination | WHFPELAKIVTDSVA CCCHHHHHHHHHHHH | 50.78 | 17644757 | |
| 219 | Phosphorylation | MGIRSKASETDLSEI HCCCCCCCCCCHHHH | 44.77 | 28889911 | |
| 224 | Phosphorylation | KASETDLSEILPEEI CCCCCCHHHHCHHHH | 25.96 | 30377154 | |
| 281 | Ubiquitination | NYLSARMKAIAPNLT HHHHHHHHHHHCCHH | 30.96 | 23749301 | |
| 303 | Phosphorylation | GARLIAHSGSLISLA HHHHHHCCCCHHHHC | 22.51 | 21440633 | |
| 311 | Ubiquitination | GSLISLAKSPASTIQ CCHHHHCCCCHHHHH | 63.37 | 17644757 | |
| 312 | Phosphorylation | SLISLAKSPASTIQI CHHHHCCCCHHHHHH | 21.79 | 24961812 | |
| 315 | Phosphorylation | SLAKSPASTIQILGA HHCCCCHHHHHHHCH | 29.44 | 24961812 | |
| 316 | Phosphorylation | LAKSPASTIQILGAE HCCCCHHHHHHHCHH | 21.00 | 27017623 | |
| 324 | Acetylation | IQILGAEKALFRALK HHHHCHHHHHHHHHH | 50.27 | 24489116 | |
| 324 | Ubiquitination | IQILGAEKALFRALK HHHHCHHHHHHHHHH | 50.27 | 22817900 | |
| 338 | Ubiquitination | KTKHDTPKYGLLYHA HCCCCCCCCCHHHHH | 54.78 | 17644757 | |
| 354 | Ubiquitination | LVGQATGKNKGKIAR HCCCCCCCCHHHHHH | 51.65 | 17644757 | |
| 356 | Acetylation | GQATGKNKGKIARVL CCCCCCCHHHHHHHH | 66.13 | 25381059 | |
| 358 | Acetylation | ATGKNKGKIARVLAA CCCCCHHHHHHHHHH | 34.50 | 25381059 | |
| 366 | Ubiquitination | IARVLAAKAAVSLRY HHHHHHHHHHHHHHH | 31.13 | 23749301 | |
| 383 | Phosphorylation | LAEDRDDSGDIGLES HHCCCCCCCCCCHHH | 42.53 | 23749301 | |
| 399 | Phosphorylation | AKVENRLSQLEGRDL HHHHHHHHHHCCCCC | 29.49 | 27214570 | |
| 408 | Phosphorylation | LEGRDLRTTPKVVRE HCCCCCCCCHHHHHH | 55.54 | 24961812 | |
| 409 | Phosphorylation | EGRDLRTTPKVVREA CCCCCCCCHHHHHHH | 18.06 | 24961812 | |
| 418 | Acetylation | KVVREAKKVEMTEAR HHHHHHHHHCCCHHH | 50.94 | 25381059 | |
| 438 | Phosphorylation | ADTAKAASDSESDSD HHHHHHHCCCCCCCC | 46.67 | 19684113 | |
| 440 | Phosphorylation | TAKAASDSESDSDDE HHHHHCCCCCCCCHH | 36.18 | 19795423 | |
| 442 | Phosphorylation | KAASDSESDSDDEEE HHHCCCCCCCCHHHH | 46.49 | 19795423 | |
| 444 | Phosphorylation | ASDSESDSDDEEEEK HCCCCCCCCHHHHHH | 57.13 | 19795423 | |
| 467 | Phosphorylation | KRDDDEDSKDSKKAK CCCCCCCCHHHHHHH | 35.99 | 27214570 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NOP58_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOP58_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOP58_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399, AND MASSSPECTROMETRY. | |
