UTP20_YEAST - dbPTM
UTP20_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UTP20_YEAST
UniProt AC P35194
Protein Name U3 small nucleolar RNA-associated protein 20
Gene Name UTP20
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 2493
Subcellular Localization Cytoplasm. Nucleus, nucleolus.
Protein Description Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly..
Protein Sequence MAKQRQTTKSSKRYRYSSFKARIDDLKIEPARNLEKRVHDYVESSHFLASFDQWKEINLSAKFTEFAAEIEHDVQTLPQILYHDKKIFNSLVSFINFHDEFSLQPLLDLLAQFCHDLGPDFLKFYEEAIKTLINLLDAAIEFESSNVFEWGFNCLAYIFKYLSKFLVKKLVLTCDLLIPLLSHSKEYLSRFSAEALSFLVRKCPVSNLREFVRSVFEKLEGDDEQTNLYEGLLILFTESMTSTQETLHSKAKAIMSVLLHEALTKSSPERSVSLLSDIWMNISKYASIESLLPVYEVMYQDFNDSLDATNIDRILKVLTTIVFSESGRKIPDWNKITILIERIMSQSENCASLSQDKVAFLFALFIRNSDVKTLTLFHQKLFNYALTNISDCFLEFFQFALRLSYERVFSFNGLKFLQLFLKKNWQSQGKKIALFFLEVDDKPELQKVREVNFPEEFILSIRDFFVTAEINDSNDLFEIYWRAIIFKYSKLQNTEIIIPLLERIFSTFASPDNFTKDMVGTLLKIYRKEDDASGNNLLKTILDNYENYKESLNFLRGWNKLVSNLHPSESLKGLMSHYPSLLLSLTDNFMLPDGKIRYETLELMKTLMILQGMQVPDLLSSCMVIEEIPLTLQNARDLTIRIKNVGAEFGKTKTDKLVSSFFLKYLFGLLTVRFSPVWTGVFDTLPNVYTKDEALVWKLVLSFIKLPDENQNLDYYQPLLEDGANKVLWDSSVVRLRDTIDTFSHIWSKYSTQNTSIISTTIERRGNTTYPILIRNQALKVMLSIPQVAENHFVDIAPFVYNDFKTYKDEEDMENERVITGSWTEVDRNVFLKTLSKFKNIKNVYSATELHDHLMVLLGSRNTDVQKLALDALLAYKNPTLNKYRDNLKNLLDDTLFKDEITTFLTENGSQSIKAEDEKVVMPYVLRIFFGRAQVPPTSGQKRSRKIAVISVLPNFKKPYINDFLSLASERLDYNYFFGNSHQINSSKATLKTIRRMTGFVNIVNSTLSVLRTNFPLHTNSVLQPLIYSIAMAYYVLDTESTEEVHLRKMASNLRQQGLKCLSSVFEFVGNTFDWSTSMEDIYAVVVKPRISHFSDENLQQPSSLLRLFLYWAHNPSLYQFLYYDEFATATALMDTISNQHVKEAVIGPIIEAADSIIRNPVNDDHYVDLVTLICTSCLKILPSLYVKLSDSNSISTFLNLLVSITEMGFIQDDHVRSRLISSLISILKGKLKKLQENDTQKILKILKLIVFNYNCSWSDIEELYTTISSLFKTFDERNLRVSLTELFIELGRKVPELESISKLVADLNSYSSSRMHEYDFPRILSTFKGLIEDGYKSYSELEWLPLLFTFLHFINNKEELALRTNASHAIMKFIDFINEKPNLNEASKSISMLKDILLPNIRIGLRDSLEEVQSEYVSVLSYMVKNTKYFTDFEDMAILLYNGDEEADFFTNVNHIQLHRRQRAIKRLGEHAHQLKDNSISHYLIPMIEHYVFSDDERYRNIGNETQIAIGGLAQHMSWNQYKALLRRYISMLKTKPNQMKQAVQLIVQLSVPLRETLRIVRDGAESKLTLSKFPSNLDEPSNFIKQELYPTLSKILGTRDDETIIERMPIAEALVNIVLGLTNDDITNFLPSILTNICQVLRSKSEELRDAVRVTLGKISIILGAEYLVFVIKELMATLKRGSQIHVLSYTVHYILKSMHGVLKHSDLDTSSSMIVKIIMENIFGFAGEEKDSENYHTKVKEIKSNKSYDAGEILASNISLTEFGTLLSPVKALLMVRINLRNQNKLSELLRRYLLGLNHNSDSESESILKFCHQLFQESEMSNSPQIPKKKVKDQVDEKEDFFLVNLESKSYTINSNSLLLNSTLQKFALDLLRNVITRHRSFLTVSHLEGFIPFLRDSLLSENEGVVISTLRILITLIRLDFSDESSEIFKNCARKVLNIIKVSPSTSSELCQMGLKFLSAFIRHTDSTLKDTALSYVLGRVLPDLNEPSRQGLAFNFLKALVSKHIMLPELYDIADTTREIMVTNHSKEIRDVSRSVYYQFLMEYDQSKGRLEKQFKFMVDNLQYPTESGRQSVMELINLIITKANPALLSKLSSSFFLALVNVSFNDDAPRCREMASVLISTMLPKLENKDLEIVEKYIAAWLKQVDNASFLNLGLRTYKVYLKSIGFEHTIELDELAIKRIRYILSDTSVGSEHQWDLVYSALNTFSSYMEATESVYKHGFKDIWDGIITCLLYPHSWVRQSAANLVHQLIANKDKLEISLTNLEIQTIATRILHQLGAPSIPENLANVSIKTLVNISILWKEQRTPFIMDVSKQTGEDLKYTTAIDYMVTRIGGIIRSDEHRMDSFMSKKACIQLLALLVQVLDEDEVIAEGEKILLPLYGYLETYYSRAVDEEQEELRTLSNECLKILEDKLQVSDFTKIYTAVKQTVLERRKERRSKRAILAVNAPQISADKKLRKHARSREKRKHEKDENGYYQRRNKRKRA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
252UbiquitinationETLHSKAKAIMSVLL
HHHHHHHHHHHHHHH		42.0317644757
265UbiquitinationLLHEALTKSSPERSV
HHHHHHHCCCCHHHH		50.1917644757
515PhosphorylationFASPDNFTKDMVGTL
CCCCCCCCHHHHHHH		32.1823749301
516UbiquitinationASPDNFTKDMVGTLL
CCCCCCCHHHHHHHH		39.4223749301
521PhosphorylationFTKDMVGTLLKIYRK
CCHHHHHHHHHHHCC		19.9423749301
539UbiquitinationASGNNLLKTILDNYE
CCCCHHHHHHHHCHH		36.3617644757
549UbiquitinationLDNYENYKESLNFLR
HHCHHHHHHHHHHHH		53.0317644757
560AcetylationNFLRGWNKLVSNLHP
HHHHHHHHHHHCCCC		43.7024489116
643UbiquitinationRDLTIRIKNVGAEFG
HHHEEEEEECCHHHC		35.4123749301
731PhosphorylationANKVLWDSSVVRLRD
CCCEECCCCHHHHHH		17.2830377154
822PhosphorylationNERVITGSWTEVDRN
CCEEEECCCCCCCHH		23.3630377154
883AcetylationYKNPTLNKYRDNLKN
HHCCCHHHHHHHHHH		44.7924489116
1381AcetylationFIDFINEKPNLNEAS
HHHHHHCCCCCCHHH		34.4224489116
1569UbiquitinationVRDGAESKLTLSKFP
HHCCCCCCEEHHHCC		36.6817644757
1574AcetylationESKLTLSKFPSNLDE
CCCEEHHHCCCCCCC		65.4924489116
1574UbiquitinationESKLTLSKFPSNLDE
CCCEEHHHCCCCCCC		65.4917644757
1577PhosphorylationLTLSKFPSNLDEPSN
EEHHHCCCCCCCCCH		53.8317563356
1587UbiquitinationDEPSNFIKQELYPTL
CCCCHHHHHHHHHHH		33.3217644757
1596UbiquitinationELYPTLSKILGTRDD
HHHHHHHHHHCCCCC		45.0917644757
1645PhosphorylationNICQVLRSKSEELRD
HHHHHHHHCCHHHHH		36.0528889911
1647PhosphorylationCQVLRSKSEELRDAV
HHHHHHCCHHHHHHH		37.2328889911
1825PhosphorylationLFQESEMSNSPQIPK
HHHHHHHCCCCCCCH		30.0628889911
1827PhosphorylationQESEMSNSPQIPKKK
HHHHHCCCCCCCHHH		15.7528152593
1854PhosphorylationLVNLESKSYTINSNS
EEECCCCCEEECCCC		36.4719823750
1855PhosphorylationVNLESKSYTINSNSL
EECCCCCEEECCCCH		18.5119823750
1856PhosphorylationNLESKSYTINSNSLL
ECCCCCEEECCCCHH		22.3019823750
1859PhosphorylationSKSYTINSNSLLLNS
CCCEEECCCCHHCCH		24.7619823750
1861PhosphorylationSYTINSNSLLLNSTL
CEEECCCCHHCCHHH		21.8819823750
1866PhosphorylationSNSLLLNSTLQKFAL
CCCHHCCHHHHHHHH		30.3919823750
1867PhosphorylationNSLLLNSTLQKFALD
CCHHCCHHHHHHHHH		31.9419823750
1975AcetylationRHTDSTLKDTALSYV
HCCCCCCHHHHHHHH		53.7924489116
1980PhosphorylationTLKDTALSYVLGRVL
CCHHHHHHHHHHHCC		15.6728889911
2072PhosphorylationVDNLQYPTESGRQSV
HHCCCCCCHHHHHHH		37.5428889911
2074PhosphorylationNLQYPTESGRQSVME
CCCCCCHHHHHHHHH		41.5828889911
2136AcetylationMLPKLENKDLEIVEK
HHHHHCCCCHHHHHH		55.0724489116
2156PhosphorylationLKQVDNASFLNLGLR
HHCCCCHHHHCCCCE		36.2028889911
2388PhosphorylationEKILLPLYGYLETYY
CEEEHHHHHHHHHHH		11.2030377154
2393PhosphorylationPLYGYLETYYSRAVD
HHHHHHHHHHHHCCC		25.7630377154
2394PhosphorylationLYGYLETYYSRAVDE
HHHHHHHHHHHCCCH		7.0630377154
2395PhosphorylationYGYLETYYSRAVDEE
HHHHHHHHHHCCCHH		10.0930377154
2396PhosphorylationGYLETYYSRAVDEEQ
HHHHHHHHHCCCHHH		11.8930377154
2420AcetylationCLKILEDKLQVSDFT
HHHHHHHHCCCCHHH		31.2924489116
2459PhosphorylationAVNAPQISADKKLRK
EECCCCCCCCHHHHH		25.7630377154
2462AcetylationAPQISADKKLRKHAR
CCCCCCCHHHHHHHH		54.1224489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UTP20_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UTP20_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UTP20_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MPP10_YEASTMPP10physical
15590835
SN114_YEASTSNU114physical
18467557
UTP10_YEASTUTP10physical
21724601
UTP17_YEASTNAN1physical
21724601
UTP4_YEASTUTP4physical
21724601
UTP8_YEASTUTP8physical
21724601
PWP2_YEASTPWP2physical
21724601
UTP12_YEASTDIP2physical
21724601
UTP21_YEASTUTP21physical
21724601
UTP13_YEASTUTP13physical
21724601
IMP4_YEASTIMP4physical
21724601
RRP9_YEASTRRP9physical
21724601
FBRL_YEASTNOP1physical
21724601
UTP20_YEASTUTP20physical
21724601
BMS1_YEASTBMS1physical
21724601
NAT10_YEASTKRE33physical
21724601
NOP14_YEASTNOP14physical
21724601
BFR2_YEASTBFR2physical
21724601
XRN2_YEASTRAT1physical
21724601
MSH2_YEASTMSH2physical
21724601
MSH4_YEASTMSH4physical
21724601
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UTP20_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1577, AND MASSSPECTROMETRY.

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