| UniProt ID | UTP4_YEAST | |
|---|---|---|
| UniProt AC | Q06679 | |
| Protein Name | U3 small nucleolar RNA-associated protein 4 | |
| Gene Name | UTP4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 776 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).. | |
| Protein Sequence | MSSSLLSVLKEKSRSLKIRNKPVKMTSQERMIVHRCRFVDFTPATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSESTVKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDLLLRTSTKLVKFIDNSKIVICSCEDDVFIVDLESEEDEKPQEVELLEVTSTKSSIKVPYINRINHLEVDQNIAVISRGCGVVDILDLKARISKPLARLNNFITAVHINTSRKSVVVITADNKIYEFNMNLNSEAENEDSESVLTQWSKNNTDNLPKEWKTLKENCVGIFSDIENSSRLWFWGATWISRIDFDVDFPINKRRKQKKRTHEGLTITDESNFMNDEEDDEDDDIDMEISENLNVLLNQGNKIKSTDVQRNEESSGHFFFTDKYKPLLFVDLISSNELAIIERNPLTFHSKQKAFIQPKLVF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSSLLSVL ------CCHHHHHHH | 28.74 | 19823750 | |
| 3 | Phosphorylation | -----MSSSLLSVLK -----CCHHHHHHHH | 24.57 | 19823750 | |
| 4 | Phosphorylation | ----MSSSLLSVLKE ----CCHHHHHHHHH | 26.48 | 19823750 | |
| 7 | Phosphorylation | -MSSSLLSVLKEKSR -CCHHHHHHHHHHHC | 30.60 | 28889911 | |
| 59 | Acetylation | SHKSNINKLTPSDLR HCCCCCCCCCHHHHH | 50.36 | 24489116 | |
| 105 | Phosphorylation | SIEGLCWSNVNGESL CEEECEEECCCCCEE | 29.88 | 27017623 | |
| 157 | Phosphorylation | NDSQDKLSVGCDNGT CCCCCCEEEECCCCE | 23.39 | 28889911 | |
| 164 | Phosphorylation | SVGCDNGTVVLIDIS EEECCCCEEEEEECC | 17.44 | 28889911 | |
| 181 | Phosphorylation | PGVLEHDTILMRQEA CCCCCCCEEEHHHHH | 20.23 | 28889911 | |
| 395 | Phosphorylation | QRLVVSWSESTVKIW CEEEEEECCCCEEEE | 17.73 | 28889911 | |
| 397 | Phosphorylation | LVVSWSESTVKIWTM EEEEECCCCEEEEEE | 32.74 | 28889911 | |
| 459 | Acetylation | HLQPVGNKLKVTKLD EEEECCCEEEEEECC | 43.70 | 24489116 | |
| 464 | Acetylation | GNKLKVTKLDNDLLL CCEEEEEECCCCHHH | 57.75 | 24489116 | |
| 667 | Acetylation | DVDFPINKRRKQKKR CCCCCCCCCCCCCCC | 55.06 | 24489116 | |
| 685 | Phosphorylation | GLTITDESNFMNDEE CCCCCCCCCCCCCCC | 37.87 | 28889911 | |
| 728 | Phosphorylation | DVQRNEESSGHFFFT CCCCCCCCCCCCEEC | 35.13 | 29734811 | |
| 735 | Phosphorylation | SSGHFFFTDKYKPLL CCCCCEECCCCCCEE | 26.82 | 29734811 | |
| 773 | Acetylation | QKAFIQPKLVF---- CCCCCCCCCCC---- | 40.69 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UTP4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UTP4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UTP4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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