dbPTM

CMS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CMS1_YEAST
UniProt AC	Q07897
Protein Name	Protein CMS1
Gene Name	CMS1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	291
Subcellular Localization	Nucleus .
Protein Description	May play a role in the regulation of DNA replication and cell cycle control..
Protein Sequence	MSNPDDLDDGLAYDFDAEHEVIFDAKDGSPPTKKVQKRSIEQDDDDVDDIDGKKEERNSEDDSNRPISKRQKKLQKKSKLIEKKKEESQYIVSQRKALPASSPEKIIEYLTTLIREKNPDLSVLELEELYFKRNDFLSTEKFDAERRLSNFPAFIQKFSVAPKKIVFSMSNIRVADVYRSLNGGKNCVKLFSKSKLKDDIATVERLLTDSSKKSNKNKDSLYFIATPTRMQKIIEATDLLFQGKEKLDIILDASYLDPKDNTILSFENAAVLCQVLKTFLNKKSSVKILLY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSNPDDLDD ------CCCHHHCCC	58.00	28152593
29	Phosphorylation	IFDAKDGSPPTKKVQ EEECCCCCCCCHHHH	37.53	25752575
39	Phosphorylation	TKKVQKRSIEQDDDD CHHHHCCCCCCCCCC	37.20	17563356
53	Acetylation	DVDDIDGKKEERNSE CCCCCCCCCHHCCCC	53.95	24489116
54	Acetylation	VDDIDGKKEERNSED CCCCCCCCHHCCCCC	71.04	24489116
59	Phosphorylation	GKKEERNSEDDSNRP CCCHHCCCCCCCCCC	48.93	19823750
63	Phosphorylation	ERNSEDDSNRPISKR HCCCCCCCCCCCHHH	47.24	19795423
68	Phosphorylation	DDSNRPISKRQKKLQ CCCCCCCHHHHHHHH	25.19	27214570
69	Acetylation	DSNRPISKRQKKLQK CCCCCCHHHHHHHHH	60.61	25381059
88	Phosphorylation	IEKKKEESQYIVSQR HHHHHHHHHHHHHHH	29.40	30377154
93	Phosphorylation	EESQYIVSQRKALPA HHHHHHHHHHCCCCC	18.08	27017623
141	Acetylation	NDFLSTEKFDAERRL CCCCCCCCCCHHHHH	48.94	24489116
157	Acetylation	NFPAFIQKFSVAPKK CCHHHHHHHCCCCCE	34.49	24489116
168	Phosphorylation	APKKIVFSMSNIRVA CCCEEEEEECCCCHH	15.48	27017623
170	Phosphorylation	KKIVFSMSNIRVADV CEEEEEECCCCHHHH	28.10	27017623
178	Phosphorylation	NIRVADVYRSLNGGK CCCHHHHHHHHCCCC	8.60	27017623
195	Acetylation	VKLFSKSKLKDDIAT HHHHCCCCCHHHHHH	64.39	24489116
197	Acetylation	LFSKSKLKDDIATVE HHCCCCCHHHHHHHH	58.03	24489116
216	Acetylation	DSSKKSNKNKDSLYF CCCCCCCCCCCCEEE	72.90	24489116
218	Acetylation	SKKSNKNKDSLYFIA CCCCCCCCCCEEEEE	50.75	24489116
218	Succinylation	SKKSNKNKDSLYFIA CCCCCCCCCCEEEEE	50.75	23954790
232	Acetylation	ATPTRMQKIIEATDL ECHHHHHHHHHHHHH	35.99	24489116
244	Acetylation	TDLLFQGKEKLDIIL HHHHHCCHHHCCEEE	40.67	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CMS1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CMS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CMS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CMS1_YEAST !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CMS1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39 AND SER-59, AND MASSSPECTROMETRY.	17563356 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND MASSSPECTROMETRY.	17287358 [Abstract]