| UniProt ID | UTP8_YEAST | |
|---|---|---|
| UniProt AC | P53276 | |
| Protein Name | U3 small nucleolar RNA-associated protein 8 | |
| Gene Name | UTP8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 713 | |
| Subcellular Localization | Nucleus, nucleolus . Associated with ribosomal chromatin, even in the absence of transcription. | |
| Protein Description | Involved in nucleolar processing of pre-18S ribosomal RNA. Also has a role in nuclear tRNA export. It acts between the steps of tRNA maturation/aminoacylation and its subsequent translocation out of the nucleus. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).. | |
| Protein Sequence | MPSLSQPFRLATLPKIASLSNFSLQADYVQVADGTFNESTNNITLGISGSSISQYIINPTPKLTFDYPIPSTNIITACNAEKGQANIDGNIEASTDDEANNEKTINTQKKRNVEIWAFGLMVNKGNYTLNVITKALEDTTDTSNDHLSESDIDNKAYTGSDEFLSQYKIKAKAKVMSIKIDTKNSLVIAILQNGLIEIFDFKLTLLHSFDISYDNLKYAKWFTENGTEYVFVLCPLQDDKVCYKLLELTDCGSGESSPIKELSSTIIEGFSFENSKLCYQFGKLYKLNQGKIYIYSLPHCQLQQVIEFPMVDKLSPGDDLISFQPVSVNRVLLTVNNVIYLLDLLHCSTLSQRELTHVKTFQLLKSAVINSEKSHNSKTIAIGISTKNGPNPTSSLEIINIDVGTNTLKDSLGKSFQVGNNDSSVILKPLFDDKDINDKRVKCNDVSGDSSVPVLHCNEVIEKLSALQDNDITSFDDIFFKELKIKEEHYTEKDRYISDPGFLNKVLDLIFGKFSGNDYPKTLTFLLTHPLFPLSRTRNLLSLLRDQPRLFKQAIVTCPNLPLNELLEELFSIRNRELLLDISFRILQDFTRDSIKQEMKKLSKLDVQNFIEFITSGGEDSSPECFNPSQSTQLFQLLSLVLDSIGLFSLEGALLENLTLYIDKQVEIAERNTELWNLIDTKGFQHGFASSTFDNGTSQKRALPTYTMEYLDI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 94 | Phosphorylation | IDGNIEASTDDEANN CCCCEEECCCCCCCC | 21.41 | 25521595 | |
| 95 | Phosphorylation | DGNIEASTDDEANNE CCCEEECCCCCCCCC | 55.29 | 25521595 | |
| 139 | Phosphorylation | ITKALEDTTDTSNDH HHHHHHCCCCCCCCC | 19.73 | 29136822 | |
| 140 | Phosphorylation | TKALEDTTDTSNDHL HHHHHCCCCCCCCCC | 49.99 | 29136822 | |
| 142 | Phosphorylation | ALEDTTDTSNDHLSE HHHCCCCCCCCCCCH | 27.60 | 20377248 | |
| 143 | Phosphorylation | LEDTTDTSNDHLSES HHCCCCCCCCCCCHH | 42.97 | 22369663 | |
| 148 | Phosphorylation | DTSNDHLSESDIDNK CCCCCCCCHHHCCCC | 31.47 | 22369663 | |
| 150 | Phosphorylation | SNDHLSESDIDNKAY CCCCCCHHHCCCCCC | 36.17 | 22369663 | |
| 167 | Phosphorylation | SDEFLSQYKIKAKAK CHHHHHHHHHHHEEE | 16.00 | 20377248 | |
| 168 | Acetylation | DEFLSQYKIKAKAKV HHHHHHHHHHHEEEE | 30.05 | 24489116 | |
| 359 | Acetylation | QRELTHVKTFQLLKS HHHCCCHHHHHHHHH | 35.70 | 24489116 | |
| 423 | Phosphorylation | FQVGNNDSSVILKPL EECCCCCCCEEEEEC | 28.73 | 22369663 | |
| 424 | Phosphorylation | QVGNNDSSVILKPLF ECCCCCCCEEEEECC | 18.95 | 22369663 | |
| 692 | Phosphorylation | QHGFASSTFDNGTSQ CCCCCCCCCCCCCCC | 32.29 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UTP8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UTP8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UTP8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-148, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150, AND MASSSPECTROMETRY. | |
