| UniProt ID | PYRE_YEAST | |
|---|---|---|
| UniProt AC | P13298 | |
| Protein Name | Orotate phosphoribosyltransferase 1 | |
| Gene Name | URA5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 226 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).. | |
| Protein Sequence | MPIMLEDYQKNFLELAIECQALRFGSFKLKSGRESPYFFNLGLFNTGKLLSNLATAYAIAIIQSDLKFDVIFGPAYKGIPLAAIVCVKLAEIGGSKFQNIQYAFNRKEAKDHGEGGIIVGSALENKRILIIDDVMTAGTAINEAFEIISNAKGQVVGSIIALDRQEVVSTDDKEGLSATQTVSKKYGIPVLSIVSLIHIITYLEGRITAEEKSKIEQYLQTYGASA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Acetylation | ALRFGSFKLKSGRES HHCCCCEECCCCCCC | 57.62 | 25381059 | |
| 28 | Ubiquitination | ALRFGSFKLKSGRES HHCCCCEECCCCCCC | 57.62 | 23749301 | |
| 96 | Acetylation | LAEIGGSKFQNIQYA HHHHCCHHHHCHHHC | 55.00 | 24489116 | |
| 107 | Acetylation | IQYAFNRKEAKDHGE HHHCCCHHHHHHCCC | 64.23 | 24489116 | |
| 110 | Acetylation | AFNRKEAKDHGEGGI CCCHHHHHHCCCCCE | 51.88 | 24489116 | |
| 173 | Acetylation | EVVSTDDKEGLSATQ EEECCCCCCCCCCHH | 57.39 | 24489116 | |
| 173 | Ubiquitination | EVVSTDDKEGLSATQ EEECCCCCCCCCCHH | 57.39 | 23749301 | |
| 212 | 2-Hydroxyisobutyrylation | GRITAEEKSKIEQYL CCCCHHHHHHHHHHH | 48.86 | - | |
| 213 | Phosphorylation | RITAEEKSKIEQYLQ CCCHHHHHHHHHHHH | 41.99 | 28889911 | |
| 214 | Acetylation | ITAEEKSKIEQYLQT CCHHHHHHHHHHHHH | 62.42 | 24489116 | |
| 214 | Ubiquitination | ITAEEKSKIEQYLQT CCHHHHHHHHHHHHH | 62.42 | 23749301 | |
| 225 | Phosphorylation | YLQTYGASA------ HHHHHCCCC------ | 30.10 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PYRE_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PYRE_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PYRE_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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