| UniProt ID | RMI1_YEAST | |
|---|---|---|
| UniProt AC | Q02685 | |
| Protein Name | RecQ-mediated genome instability protein 1 | |
| Gene Name | RMI1 {ECO:0000312|SGD:S000005945} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 241 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with SGS1 and TOP3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response. Required for resistance to the DNA-damaging agent methyl methanesulfonate (MMS).. | |
| Protein Sequence | MSFSSILSQDITDDITPPAYSATLGSREQIVFRAYQNEPWLAGTASNLILDKKLVIVDRELLFQVLMVENITKSKLTQIDDIKTKLDPKKQKVDRLRSGAQGNGAKKYEVITQVDMEDDGNVADNNCAKENNSNNNSSAAKNKAVFKLTLQSKSGDVFFAINSTPISWSSCMLGSKIVILPGTVFNRGVFILKDSQVIFLGGINRVWNENRDQKFCDYLESKLQRDKQLVNGGSKKRKAND | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MSFSSILSQDITDDI CCHHHHCCCCCCCCC | 24.92 | 30377154 | |
| 12 | Phosphorylation | SILSQDITDDITPPA HHCCCCCCCCCCCCC | 35.59 | 30377154 | |
| 16 | Phosphorylation | QDITDDITPPAYSAT CCCCCCCCCCCCCCC | 30.16 | 30377154 | |
| 98 | Phosphorylation | QKVDRLRSGAQGNGA HHHHHHHHCCCCCCC | 42.97 | 17563356 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RMI1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RMI1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RMI1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND MASSSPECTROMETRY. | |
