ESC8_YEAST - dbPTM
ESC8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ESC8_YEAST
UniProt AC Q08119
Protein Name Protein ESC8
Gene Name ESC8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 714
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Involved in HMR and telomere silencing via the recruitment or stabilizing of the SIR (silent information regulators) complex..
Protein Sequence MTEIIDLDLVDDFIKKPMVKQQKNQSSKPRVKRRGQLTFDDFRNIKIVEEPVVLSHNSSIDESLDAATQNTKKREKYEGTCDEEMKTKEMEANMASKYSNIKTHSNDTNKVESISEHTTSNNRPLNTLNWSPNIPLRYSDFAKFMSDETVTESNWAPPLCTPLPYAGDVMKILSFIVKFKWVFSDDLLNLSFQDVEIGLELKVAGHSAKNIRICQDKMNLLFCSLLRLLFCSEKRADNQTHRNFTLKRFLSLKNPYGKLVGKLRSLIQEWGLPKEWRGNSDILSTLNFNGGGLLTMEPLDRIILLRCMIDWNCSYSALFHNEIQRLTHLKGDTGFNHQTFHASRFAMCGANNILDSCEVLCSLMSQKLENRKKRKPSDKGKLSKINSQMKFLKGVRKSLSEKVTTDRLRAAVKINEEWGEYFANEFTHTPIDDPTVDEIYKLRTSEFMIARIPRVGDFYLPPFWIGNECSSVNTSYSFNDMSTYLNYFVKFKEEGTKILPAKTAQNENKCQLKLIYRNTPACIRNLQFNDVHFAEVPHWFEVAGDSNSLSNFIEYLESLSSLTENDTDDTKKGIDNLIEFLKIFSIFINETIQRITAAPTGSTEGRHLRTSSQRRTTVHYSSDVNGDVSEESENEVDIDVSDDYDSEYLSEENTLTRKGEDRTDKSFGKRELHNGAKDCDRNCDDIEIFSEPVRQLQDNSREKRSLRRNARKGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
55PhosphorylationVEEPVVLSHNSSIDE
EECCEEECCCCCCCH		14.7130377154
58PhosphorylationPVVLSHNSSIDESLD
CEEECCCCCCCHHHH		24.2130377154
59PhosphorylationVVLSHNSSIDESLDA
EEECCCCCCCHHHHH		39.1030377154
63PhosphorylationHNSSIDESLDAATQN
CCCCCCHHHHHHHHH		28.0030377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ESC8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ESC8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ESC8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SIR2_YEASTSIR2physical
12399377
MED15_YEASTGAL11physical
12399377
ISW1_YEASTISW1physical
16554755
YPT6_YEASTYPT6genetic
17314980
RGP1_YEASTRGP1genetic
17314980
ORM2_YEASTORM2genetic
17314980
SWC5_YEASTSWC5genetic
17314980
SAC3_YEASTSAC3genetic
17314980
TFS2_YEASTDST1genetic
17314980
RSC9_YEASTRSC9genetic
17314980
TAF1_YEASTTAF1genetic
17314980
RPC8_YEASTRPC25genetic
17314980
GET2_YEASTGET2genetic
17314980
RSP5_YEASTRSP5genetic
17314980
TAF13_YEASTTAF13genetic
17314980
COPE_YEASTSEC28genetic
17314980
SPT21_YEASTSPT21genetic
17314980
TF3B_YEASTBRF1genetic
17314980
SWR1_YEASTSWR1genetic
17314980
VID22_YEASTVID22genetic
17314980
MMS22_YEASTMMS22genetic
17314980
RPD3_YEASTRPD3genetic
17314980
ARO1_YEASTARO1genetic
17314980
PLPHP_YEASTYBL036Cgenetic
17314980
TOS2_YEASTTOS2genetic
17314980
SRS2_YEASTSRS2genetic
21459050
SIR4_YEASTSIR4genetic
27185881
RL27B_YEASTRPL27Bgenetic
27708008
PPB_YEASTPHO8genetic
27708008
YEW0_YEASTCOM2genetic
27708008
PMD1_YEASTPMD1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
MIC19_YEASTMIC19genetic
27708008
AXL2_YEASTAXL2genetic
27708008
ALN_YEASTDAL1genetic
27708008
SET2_YEASTSET2genetic
27708008
MTNB_YEASTMDE1genetic
27708008
RFX1_YEASTRFX1genetic
27708008
METK1_YEASTSAM1genetic
27708008
DUS3_YEASTDUS3genetic
27708008
SRR1L_YEASTBER1genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
MET8_YEASTMET8genetic
27708008
CHK1_YEASTCHK1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
PP2A1_YEASTPPH21genetic
27708008
FDC1_YEASTFDC1genetic
27708008
SPO73_YEASTSPO73genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
YFH6_YEASTYFR006Wgenetic
27708008
YG036_YEASTYGL036Wgenetic
27708008
KEX1_YEASTKEX1genetic
27708008
EDC1_YEASTEDC1genetic
27708008
YG1O_YEASTYGR035Cgenetic
27708008
ASK10_YEASTASK10genetic
27708008
VMA21_YEASTVMA21genetic
27708008
AZR1_YEASTAZR1genetic
27708008
CPD1_YEASTCPD1genetic
27708008
YG5X_YEASTYGR283Cgenetic
27708008
YLF2_YEASTYLF2genetic
27708008
IGO2_YEASTIGO2genetic
27708008
SER33_YEASTSER33genetic
27708008
AYR1_YEASTAYR1genetic
27708008
ASG1_YEASTASG1genetic
27708008
FLX1_YEASTFLX1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
PEP8_YEASTPEP8genetic
27708008
YJH0_YEASTYJL070Cgenetic
27708008
JEM1_YEASTJEM1genetic
27708008
PHO86_YEASTPHO86genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
SFC1_YEASTSFC1genetic
27708008
YJ68_YEASTYJR098Cgenetic
27708008
MCR1_YEASTMCR1genetic
27708008
JEN1_YEASTJEN1genetic
27708008
SPO75_YEASTSPO75genetic
27708008
YL040_YEASTAFB1genetic
27708008
YPS3_YEASTYPS3genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
TMA10_YEASTTMA10genetic
27708008
NU188_YEASTNUP188genetic
27708008
BUL2_YEASTBUL2genetic
27708008
MAC1_YEASTMAC1genetic
27708008
YMZ2_YEASTYMR102Cgenetic
27708008
YM8C_YEASTYMR262Wgenetic
27708008
MLF3_YEASTMLF3genetic
27708008
LSM7_YEASTLSM7genetic
27708008
PMA2_YEASTPMA2genetic
27708008
NACB1_YEASTEGD1genetic
27708008
ATG41_YEASTICY2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ESC8_YEAST

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Related Literatures of Post-Translational Modification

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