PPB_YEAST - dbPTM
PPB_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPB_YEAST
UniProt AC P11491
Protein Name Repressible alkaline phosphatase
Gene Name PHO8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 566
Subcellular Localization Repressible alkaline phosphatase: Vacuole membrane
Single-pass membrane protein. The full-length version is found in lysosome-like vacuoles.
Soluble alkaline phosphatase: Cytoplasm. The truncated version of the protein is soluble.
Protein Description Phosphatase with broad substrate specificity. A truncated (soluble) version of the protein is responsible for the production of (E,E)-farnesol from (E,E)-farnesyl diphosphate. Acts as a fructose-2,6-bisphosphate 6-phosphatase. [PubMed: 1848184]
Protein Sequence MMTHTLPSEQTRLVPGSDSSSRPKKRRISKRSKIIVSTVVCIGLLLVLVQLAFPSSFALRSASHKKKNVIFFVTDGMGPASLSMARSFNQHVNDLPIDDILTLDEHFIGSSRTRSSDSLVTDSAAGATAFACALKSYNGAIGVDPHHRPCGTVLEAAKLAGYLTGLVVTTRITDATPASFSSHVDYRWQEDLIATHQLGEYPLGRVVDLLMGGGRSHFYPQGEKASPYGHHGARKDGRDLIDEAQSNGWQYVGDRKNFDSLLKSHGENVTLPFLGLFADNDIPFEIDRDEKEYPSLKEQVKVALGALEKASNEDKDSNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEAFQYVLEFAENSDTETVLVSTSDHETGGLVTSRQVTASYPQYVWYPQVLANATHSGEFLKRKLVDFVHEHKGASSKIENFIKHEILEKDLGIYDYTDSDLETLIHLDDNANAIQDKLNDMVSFRAQIGWTTHGHSAVDVNIYAYANKKATWSYVLNNLQGNHENTEVGQFLENFLELNLNEVTDLIRDTKHTSDFDATEIASEVQHYDEYYHELTN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MMTHTLPSEQ
-----CCCCCCCCCC		15.4827017623
5Phosphorylation---MMTHTLPSEQTR
---CCCCCCCCCCCC		31.0627017623
8PhosphorylationMMTHTLPSEQTRLVP
CCCCCCCCCCCCCCC		45.5129136822
11PhosphorylationHTLPSEQTRLVPGSD
CCCCCCCCCCCCCCC		23.1729136822
17PhosphorylationQTRLVPGSDSSSRPK
CCCCCCCCCCCCCCC		28.4022369663
19PhosphorylationRLVPGSDSSSRPKKR
CCCCCCCCCCCCCCC		31.7322369663
20PhosphorylationLVPGSDSSSRPKKRR
CCCCCCCCCCCCCCH		35.0422369663
21PhosphorylationVPGSDSSSRPKKRRI
CCCCCCCCCCCCCHH		57.4622369663
113PhosphorylationHFIGSSRTRSSDSLV
HHCCCCCCCCCCCCC		36.5322369663
115PhosphorylationIGSSRTRSSDSLVTD
CCCCCCCCCCCCCCC		37.5722890988
116PhosphorylationGSSRTRSSDSLVTDS
CCCCCCCCCCCCCCC		28.1122890988
118PhosphorylationSRTRSSDSLVTDSAA
CCCCCCCCCCCCCHH		27.0422890988
121PhosphorylationRSSDSLVTDSAAGAT
CCCCCCCCCCHHHHH		29.5422369663
123PhosphorylationSDSLVTDSAAGATAF
CCCCCCCCHHHHHHH		15.6222369663
128PhosphorylationTDSAAGATAFACALK
CCCHHHHHHHHHHHH		22.7622890988
135UbiquitinationTAFACALKSYNGAIG
HHHHHHHHHCCCCCC		32.1617644757
268N-linked_GlycosylationLLKSHGENVTLPFLG
HHHHCCCCCEECEEE		36.34-
401N-linked_GlycosylationWYPQVLANATHSGEF
CHHHHHCCCCCCHHH		41.01-
432AcetylationSKIENFIKHEILEKD
HHHHHHHHHHHHHCC		30.9224489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPB_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPB_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPB_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PPB_YEASTPHO8physical
19497047
SVP26_YEASTSVP26physical
19497047
PDX3_YEASTPDX3genetic
21623372
COX9_YEASTCOX9genetic
21623372
COPA_YEASTCOP1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
RPN12_YEASTRPN12genetic
27708008
CDC23_YEASTCDC23genetic
27708008
MAK11_YEASTMAK11genetic
27708008
PRI2_YEASTPRI2genetic
27708008
NEP1_YEASTEMG1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
HAS1_YEASTHAS1genetic
27708008
SYA_YEASTALA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPB_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-121; SER-123 ANDTHR-128, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, AND MASSSPECTROMETRY.

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