MTNB_YEAST - dbPTM
MTNB_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTNB_YEAST
UniProt AC P47095
Protein Name Methylthioribulose-1-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}
Gene Name MDE1 {ECO:0000255|HAMAP-Rule:MF_03116}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 244
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P)..
Protein Sequence MSSQDVLIHSDDPCHPANLICTLCKQFFHNNWCTGTGGGISIKDPNTNYYYLAPSGVQKEKMIPEDLFVMDAQTLEYLRSPKLYKPSACTPLFLACYQKKNAGAIIHTHSQNAVICSLLFGDEFRIANIEQIKAIPSGKVDPVTKKPMALSFFDTLKIPIIENMAHEDELIDDLHKTFKDYPDTCAVIVRRHGIFVWGPTIDKAKIFNEAIDYLMELAIKMYQMGIPPDCGIGEEKKHLKMASP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSQDVLIH
------CCCCCEEEC		36.3830377154
3Phosphorylation-----MSSQDVLIHS
-----CCCCCEEECC		29.1528889911
10PhosphorylationSQDVLIHSDDPCHPA
CCCEEECCCCCCCHH		36.3930377154
99AcetylationLFLACYQKKNAGAII
HHHHHHHHCCCCEEE		22.8624489116
144PhosphorylationSGKVDPVTKKPMALS
CCCCCCCCCCCCCCH		38.4419795423
179AcetylationDDLHKTFKDYPDTCA
HHHHHHHCCCCCCEE		62.6824489116
203AcetylationVWGPTIDKAKIFNEA
EECCCCCHHHHHHHH		47.9624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTNB_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTNB_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTNB_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTNB_YEASTMDE1physical
10688190
MTNB_YEASTMDE1physical
18719252
LTE1_YEASTLTE1genetic
20093466
PYC2_YEASTPYC2genetic
20093466
INO2_YEASTINO2genetic
20093466
HAP2_YEASTHAP2genetic
20093466
PCP1_YEASTPCP1genetic
20093466
RSC2_YEASTRSC2genetic
20093466
HSP7F_YEASTSSE1genetic
20093466
TPS2_YEASTTPS2genetic
27708008
DEP1_YEASTDEP1genetic
27708008
INO2_YEASTINO2genetic
27708008
RV167_YEASTRVS167genetic
27708008
SNF6_YEASTSNF6genetic
27708008
SDS3_YEASTSDS3genetic
27708008
RAS2_YEASTRAS2genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTNB_YEAST

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Related Literatures of Post-Translational Modification

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