PMD1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMD1_YEAST
• UniProt AC: P32634
• Protein Name: Negative regulator of sporulation PMD1
• Gene Name: PMD1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1753
• Subcellular Localization: Cytoplasm .
• Protein Description: Negatively regulates early sporulation-specific genes. Seems to exert its function by positively regulating the Ras/cAMP pathway. Required for growth under alkaline conditions. Acts synergetically with MDS3..
• Protein Sequence: MTVLQPPSSVCYPLNLPIVPNPNLDEATRKKLTLECRTGAAVELARSGVFVHGGLTLPLNLTIINSLQLQKELILYFGKQKDRNADFKTLADWISPEIFFLDLISRTWQRINTTIDTTSENELNNGLSFKERLFHSMCFTESNIYIFGGLMVSPHNGYELIATNELWKLDLKTKCWSLISENPQITRRFNHSMHVLNENNENQDTKLIIVGGLDNMDIPVKKIDIFNLRTSLWESESKSDENPASKGSSKILVNIDGMPISLSHDSNFSVLIENNQAEIPTLALYYPQREANTSRRGTDDGSFSTYAHDLDDKSKLPKHHHHHHGDLKYFESDDADENAVKTLMSPIVILPLLGNSQGARMTSNPTQNNKENSILQVPFHLQYPSGNYFNYNIVVIGFYPDPQPSNLHCFIYNIASGKWIRVNIACTECSISMHRFWKLLIWKSHHQALLLGTRTDDFCSPSVQKFDHILSFSLPMLNGYNKLVNTKHTRTNNGIANSHNLNVNLSLYDHLPYSNSSTIEHTNPYTVTQGYSLDDSGIPRLTSTATSQFENYSRYITVPLEMESTSSIFPPYAMVLGKDALEIFGKTLSDFEFITADGDSIGVPVYLLRKRWGRYFDSLLSNGYANTSFNYEFNGDTSNIISFSPHTASKTTKFGNSSQSSNGSLEKYFSKNGNSKSNSNTSLKKPHSVDFTSSTSSPKQRAISHNKLSPSEPILCADEEDSRSNTLKQHATGDTGLKETGTSNKRPISTTCSSTGMVFRVPFQDMKNSKLGLSEQSGRSTRASSVSPPPVYKKSTNDGNDSNCTLSNTPLVYRRASTVGTTTNSSVDDGFSSIRRASHPLQSYIIAKSSPSSISKASPAEKAFSRRKSSALRFIASPNQSRQTSFASTASTASVVSSTSGRRRNSNQISHLGSSASLPNSPILPVLNIPLPPQEKIPLEPLPPVPKAPSRRSSSLAEYVQFGRDSPVASRRSSHSTRKSSSSDARRISNSSLLRNTLDSQLLSNSYGSDIPYEASIQEYGMNNGRDEEEDGDNQDYGCISPSNIRPIFSTINAININGNFKEGEFFSSKSYINNEKSRRLSYISNPESVESTNSNNNAIIELEPLLTPRSLYMPWSTASVRAFAEFFYTAQINGKWLLAPVTLDLLIMAKIYEIPILYELITEVLYKIISKKEEGLSVTCEALLNLFQQKVSRYCNENEGKIRKQLDSSESYQDTLEIKRSLANIDNGYVDSYLLRNTSMAQSIHYTDDSNGETEIDMHHTGISSIGSLANRAVPTVFAGGPRDSHNSIGSIAFPSNSGVQNIRRSVSLFSPATKKKSSLSRETDPLDTSDQFTDDVPDSGPVSRQQNFPRRSSSFTETVPTEPTRYNYQNLDSSKSNRASDDKEEQNEQATLQDISNFDKYKVETLQKRNSNDGKDLDRTNDPLKNRGTEIPQNSSNLETDPFIRDSFDSDSGSSFRSDSDDLDSQLGILPFTKMNKKLQEQTSQEFDDSIDPLYKIGSSTPGSSRLHGSFSKYIRPNSQREDGSEYVNISSLENMVSPNALPPVDYVMKSIYRTSVLVNDSNLMTRTKEAIELSKVLKKLKKKVLQDISQMDDEMRETGKPIFARGSSSPTLSRQHSDVATPLKQQENTRPALKFASSSPISEGFRKSSIKFSQAPSTQISPRTSVTDFTASQQRRQHMNKRFSTQTTHSTSALFMNPAFMPSAVNTGRKESEGHCEDRSATANRTNRKEDATTNDNDNIAPFPFFGKRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
298	Phosphorylation	ANTSRRGTDDGSFST CCCCCCCCCCCCCCC	29.16	25704821
302	Phosphorylation	RRGTDDGSFSTYAHD CCCCCCCCCCCCCCC	24.02	30377154
304	Phosphorylation	GTDDGSFSTYAHDLD CCCCCCCCCCCCCCC	23.39	30377154
542	Phosphorylation	DSGIPRLTSTATSQF CCCCCCCCCCCCHHH	25.88	21126336
543	Phosphorylation	SGIPRLTSTATSQFE CCCCCCCCCCCHHHC	22.19	28889911
544	Phosphorylation	GIPRLTSTATSQFEN CCCCCCCCCCHHHCC	28.81	30377154
546	Phosphorylation	PRLTSTATSQFENYS CCCCCCCCHHHCCCE	24.13	28889911
555	Phosphorylation	QFENYSRYITVPLEM HHCCCEEEEEEEECC	8.59	19779198
557	Phosphorylation	ENYSRYITVPLEMES CCCEEEEEEEECCCC	13.72	19779198
567	Phosphorylation	LEMESTSSIFPPYAM ECCCCCCCCCCCCEE	28.47	19779198
657	Phosphorylation	KTTKFGNSSQSSNGS CCCCCCCCCCCCCCC	30.08	22369663
658	Phosphorylation	TTKFGNSSQSSNGSL CCCCCCCCCCCCCCH	37.77	22369663
660	Phosphorylation	KFGNSSQSSNGSLEK CCCCCCCCCCCCHHH	27.93	21440633
661	Phosphorylation	FGNSSQSSNGSLEKY CCCCCCCCCCCHHHH	37.26	22369663
664	Phosphorylation	SSQSSNGSLEKYFSK CCCCCCCCHHHHHCC	37.29	22369663
677	Phosphorylation	SKNGNSKSNSNTSLK CCCCCCCCCCCCCCC	45.36	21440633
679	Phosphorylation	NGNSKSNSNTSLKKP CCCCCCCCCCCCCCC	48.88	21440633
681	Phosphorylation	NSKSNSNTSLKKPHS CCCCCCCCCCCCCCC	34.95	21440633
682	Phosphorylation	SKSNSNTSLKKPHSV CCCCCCCCCCCCCCC	42.30	21440633
688	Phosphorylation	TSLKKPHSVDFTSST CCCCCCCCCCCCCCC	31.73	20377248
692	Phosphorylation	KPHSVDFTSSTSSPK CCCCCCCCCCCCCHH	19.80	22369663
693	Phosphorylation	PHSVDFTSSTSSPKQ CCCCCCCCCCCCHHH	31.45	22369663
694	Phosphorylation	HSVDFTSSTSSPKQR CCCCCCCCCCCHHHH	29.29	22369663
695	Phosphorylation	SVDFTSSTSSPKQRA CCCCCCCCCCHHHHH	32.75	22369663
696	Phosphorylation	VDFTSSTSSPKQRAI CCCCCCCCCHHHHHH	46.74	20377248
697	Phosphorylation	DFTSSTSSPKQRAIS CCCCCCCCHHHHHHC	35.88	22369663
711	Phosphorylation	SHNKLSPSEPILCAD CCCCCCCCCCCCCCC	53.26	23749301
722	Phosphorylation	LCADEEDSRSNTLKQ CCCCCCCCCHHCHHH	40.67	27017623
724	Phosphorylation	ADEEDSRSNTLKQHA CCCCCCCHHCHHHHC	37.81	28889911
749	Phosphorylation	TSNKRPISTTCSSTG CCCCCCCEEEECCCC	21.98	27017623
753	Phosphorylation	RPISTTCSSTGMVFR CCCEEEECCCCCEEE	28.92	27017623
755	Phosphorylation	ISTTCSSTGMVFRVP CEEEECCCCCEEEEE	17.01	27017623
774	Phosphorylation	KNSKLGLSEQSGRST CCCCCCCCCCCCCCC	31.62	22369663
777	Phosphorylation	KLGLSEQSGRSTRAS CCCCCCCCCCCCCCC	31.93	22369663
780	Phosphorylation	LSEQSGRSTRASSVS CCCCCCCCCCCCCCC	26.27	22369663
781	Phosphorylation	SEQSGRSTRASSVSP CCCCCCCCCCCCCCC	28.97	22369663
784	Phosphorylation	SGRSTRASSVSPPPV CCCCCCCCCCCCCCC	28.16	22369663
785	Phosphorylation	GRSTRASSVSPPPVY CCCCCCCCCCCCCCC	26.15	22369663
787	Phosphorylation	STRASSVSPPPVYKK CCCCCCCCCCCCCCC	33.37	22369663
792	Phosphorylation	SVSPPPVYKKSTNDG CCCCCCCCCCCCCCC	20.62	22369663
802	Phosphorylation	STNDGNDSNCTLSNT CCCCCCCCCCCCCCC	37.49	23749301
807	Phosphorylation	NDSNCTLSNTPLVYR CCCCCCCCCCCCEEE	22.09	30377154
809	Phosphorylation	SNCTLSNTPLVYRRA CCCCCCCCCCEEEEC	18.02	28889911
817	Phosphorylation	PLVYRRASTVGTTTN CCEEEECCCCCCCCC	23.09	22369663
818	Phosphorylation	LVYRRASTVGTTTNS CEEEECCCCCCCCCC	23.21	22369663
821	Phosphorylation	RRASTVGTTTNSSVD EECCCCCCCCCCCCC	26.55	19779198
822	Phosphorylation	RASTVGTTTNSSVDD ECCCCCCCCCCCCCC	20.32	22369663
823	Phosphorylation	ASTVGTTTNSSVDDG CCCCCCCCCCCCCCC	32.70	21440633
825	Phosphorylation	TVGTTTNSSVDDGFS CCCCCCCCCCCCCHH	29.64	22369663
826	Phosphorylation	VGTTTNSSVDDGFSS CCCCCCCCCCCCHHH	31.47	22369663
832	Phosphorylation	SSVDDGFSSIRRASH CCCCCCHHHHHHCCC	30.31	22369663
833	Phosphorylation	SVDDGFSSIRRASHP CCCCCHHHHHHCCCC	20.18	22369663
838	Phosphorylation	FSSIRRASHPLQSYI HHHHHHCCCCCCEEE	24.67	25752575
844	Phosphorylation	ASHPLQSYIIAKSSP CCCCCCEEEEEECCH	5.38	19779198
849	Phosphorylation	QSYIIAKSSPSSISK CEEEEEECCHHHHHC	38.16	23749301
850	Phosphorylation	SYIIAKSSPSSISKA EEEEEECCHHHHHCC	28.26	27717283
852	Phosphorylation	IIAKSSPSSISKASP EEEECCHHHHHCCCH	42.10	23749301
853	Phosphorylation	IAKSSPSSISKASPA EEECCHHHHHCCCHH	33.98	27717283
855	Phosphorylation	KSSPSSISKASPAEK ECCHHHHHCCCHHHH	24.90	27717283
858	Phosphorylation	PSSISKASPAEKAFS HHHHHCCCHHHHHHH	28.51	23749301
869	Phosphorylation	KAFSRRKSSALRFIA HHHHCCHHHHHHHHC	21.02	19684113
870	Phosphorylation	AFSRRKSSALRFIAS HHHCCHHHHHHHHCC	34.07	19684113
877	Phosphorylation	SALRFIASPNQSRQT HHHHHHCCCCCCCCC	21.40	22369663
881	Phosphorylation	FIASPNQSRQTSFAS HHCCCCCCCCCCCCC	32.75	22369663
950	Phosphorylation	PPVPKAPSRRSSSLA CCCCCCCCCCCCCHH	45.22	21440633
953	Phosphorylation	PKAPSRRSSSLAEYV CCCCCCCCCCHHHHH	24.14	28889911
954	Phosphorylation	KAPSRRSSSLAEYVQ CCCCCCCCCHHHHHH	27.79	28889911
955	Phosphorylation	APSRRSSSLAEYVQF CCCCCCCCHHHHHHH	32.61	28889911
966	Phosphorylation	YVQFGRDSPVASRRS HHHHCCCCCCCCCCC	21.66	23749301
989	Phosphorylation	SSDARRISNSSLLRN HHHHHHHCCHHHHHH	28.93	22369663
991	Phosphorylation	DARRISNSSLLRNTL HHHHHCCHHHHHHHH	18.64	22369663
992	Phosphorylation	ARRISNSSLLRNTLD HHHHCCHHHHHHHHC	35.36	22369663
1041	Phosphorylation	NQDYGCISPSNIRPI CCCCCEECHHHCHHC	26.76	28889911
1082	Phosphorylation	NEKSRRLSYISNPES CCCCCCCEECCCHHH	20.71	28889911
1089	Phosphorylation	SYISNPESVESTNSN EECCCHHHHCCCCCC	32.23	27738172
1092	Phosphorylation	SNPESVESTNSNNNA CCHHHHCCCCCCCCE	30.63	21440633
1095	Phosphorylation	ESVESTNSNNNAIIE HHHCCCCCCCCEEEE	40.81	21440633
1277	Phosphorylation	LANRAVPTVFAGGPR HHHCCCCEEECCCCC	22.96	19779198
1286	Phosphorylation	FAGGPRDSHNSIGSI ECCCCCCCCCCCCCE	26.33	17330950
1289	Phosphorylation	GPRDSHNSIGSIAFP CCCCCCCCCCCEECC	23.93	25752575
1292	Phosphorylation	DSHNSIGSIAFPSNS CCCCCCCCEECCCCC	14.74	15665377
1307	Phosphorylation	GVQNIRRSVSLFSPA HHCHHHHHHHHCCCC	13.25	22369663
1309	Phosphorylation	QNIRRSVSLFSPATK CHHHHHHHHCCCCCC	25.58	22369663
1312	Phosphorylation	RRSVSLFSPATKKKS HHHHHHCCCCCCCCC	20.93	22369663
1315	Phosphorylation	VSLFSPATKKKSSLS HHHCCCCCCCCCCCC	46.94	28889911
1354	Phosphorylation	QQNFPRRSSSFTETV CCCCCCCCCCCCCCC	31.45	22369663
1355	Phosphorylation	QNFPRRSSSFTETVP CCCCCCCCCCCCCCC	27.88	22369663
1356	Phosphorylation	NFPRRSSSFTETVPT CCCCCCCCCCCCCCC	37.12	22369663
1358	Phosphorylation	PRRSSSFTETVPTEP CCCCCCCCCCCCCCC	32.47	22369663
1360	Phosphorylation	RSSSFTETVPTEPTR CCCCCCCCCCCCCCC	28.82	22369663
1363	Phosphorylation	SFTETVPTEPTRYNY CCCCCCCCCCCCCCC	50.70	22369663
1366	Phosphorylation	ETVPTEPTRYNYQNL CCCCCCCCCCCCCCC	39.28	22369663
1368	Phosphorylation	VPTEPTRYNYQNLDS CCCCCCCCCCCCCCC	22.24	22369663
1370	Phosphorylation	TEPTRYNYQNLDSSK CCCCCCCCCCCCCCC	6.99	22369663
1375	Phosphorylation	YNYQNLDSSKSNRAS CCCCCCCCCCCCCCC	42.71	22369663
1376	Phosphorylation	NYQNLDSSKSNRASD CCCCCCCCCCCCCCC	39.51	22369663
1378	Phosphorylation	QNLDSSKSNRASDDK CCCCCCCCCCCCCCH	33.23	23749301
1382	Phosphorylation	SSKSNRASDDKEEQN CCCCCCCCCCHHHHH	43.00	19823750
1393	Phosphorylation	EEQNEQATLQDISNF HHHHHHHHHHHHHHH	25.33	19823750
1398	Phosphorylation	QATLQDISNFDKYKV HHHHHHHHHHHHHHH	39.47	19823750
1403	Phosphorylation	DISNFDKYKVETLQK HHHHHHHHHHHHHHH	23.31	19823750
1413	Phosphorylation	ETLQKRNSNDGKDLD HHHHHHCCCCCCCCC	40.09	27214570
1486	Phosphorylation	KKLQEQTSQEFDDSI HHHHHHHHHHCHHCC	27.66	28889911
1501	Phosphorylation	DPLYKIGSSTPGSSR CCHHHCCCCCCCCCC	34.22	24961812
1502	Phosphorylation	PLYKIGSSTPGSSRL CHHHCCCCCCCCCCC	33.15	28889911
1503	Phosphorylation	LYKIGSSTPGSSRLH HHHCCCCCCCCCCCC	33.11	21440633
1506	Phosphorylation	IGSSTPGSSRLHGSF CCCCCCCCCCCCCCC	17.31	21440633
1507	Phosphorylation	GSSTPGSSRLHGSFS CCCCCCCCCCCCCCC	44.79	21440633
1512	Phosphorylation	GSSRLHGSFSKYIRP CCCCCCCCCCCCCCC	18.66	20377248
1514	Phosphorylation	SRLHGSFSKYIRPNS CCCCCCCCCCCCCCC	26.67	28132839
1516	Phosphorylation	LHGSFSKYIRPNSQR CCCCCCCCCCCCCCC	10.85	21440633
1521	Phosphorylation	SKYIRPNSQREDGSE CCCCCCCCCCCCCCC	33.04	25704821
1592	Phosphorylation	KKVLQDISQMDDEMR HHHHHHHHHCCHHHH	27.95	21440633
1601	Phosphorylation	MDDEMRETGKPIFAR CCHHHHHHCCCCCCC	39.89	21440633
1610	Phosphorylation	KPIFARGSSSPTLSR CCCCCCCCCCCCCCC	23.30	21440633
1611	Phosphorylation	PIFARGSSSPTLSRQ CCCCCCCCCCCCCCC	43.06	19684113
1612	Phosphorylation	IFARGSSSPTLSRQH CCCCCCCCCCCCCCC	24.49	20377248
1614	Phosphorylation	ARGSSSPTLSRQHSD CCCCCCCCCCCCCCC	39.04	20377248
1616	Phosphorylation	GSSSPTLSRQHSDVA CCCCCCCCCCCCCCC	32.16	23749301
1620	Phosphorylation	PTLSRQHSDVATPLK CCCCCCCCCCCCCHH	25.99	22369663
1624	Phosphorylation	RQHSDVATPLKQQEN CCCCCCCCCHHHCCC	29.06	22369663
1640	Phosphorylation	RPALKFASSSPISEG CCCHHHHCCCCCCCC	34.19	22369663
1641	Phosphorylation	PALKFASSSPISEGF CCHHHHCCCCCCCCC	36.38	22369663
1642	Phosphorylation	ALKFASSSPISEGFR CHHHHCCCCCCCCCH	24.61	22369663
1645	Phosphorylation	FASSSPISEGFRKSS HHCCCCCCCCCHHHH	34.74	22369663
1651	Phosphorylation	ISEGFRKSSIKFSQA CCCCCHHHHCEECCC	32.79	24961812
1652	Phosphorylation	SEGFRKSSIKFSQAP CCCCHHHHCEECCCC	32.60	21440633
1656	Phosphorylation	RKSSIKFSQAPSTQI HHHHCEECCCCCCCC	22.04	22369663
1660	Phosphorylation	IKFSQAPSTQISPRT CEECCCCCCCCCCCC	35.64	22369663
1661	Phosphorylation	KFSQAPSTQISPRTS EECCCCCCCCCCCCC	28.94	22369663
1664	Phosphorylation	QAPSTQISPRTSVTD CCCCCCCCCCCCCCC	9.86	22369663
1667	Phosphorylation	STQISPRTSVTDFTA CCCCCCCCCCCCCCH	30.82	28889911
1668	Phosphorylation	TQISPRTSVTDFTAS CCCCCCCCCCCCCHH	25.05	17330950
1670	Phosphorylation	ISPRTSVTDFTASQQ CCCCCCCCCCCHHHH	25.76	17563356
1673	Phosphorylation	RTSVTDFTASQQRRQ CCCCCCCCHHHHHHH	28.36	23749301
1675	Phosphorylation	SVTDFTASQQRRQHM CCCCCCHHHHHHHHH	24.64	17563356
1688	Phosphorylation	HMNKRFSTQTTHSTS HHHHHHCCCCCCCCC	27.50	19779198
1690	Phosphorylation	NKRFSTQTTHSTSAL HHHHCCCCCCCCCCH	26.94	19779198
1694	Phosphorylation	STQTTHSTSALFMNP CCCCCCCCCCHHCCC	15.49	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PMD1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMD1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMD1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP71_YEAST	SSA1	physical	19536198
SSB1_YEAST	SSB1	physical	19536198
THRC_YEAST	THR4	genetic	27708008
IPT1_YEAST	IPT1	genetic	27708008
UME6_YEAST	UME6	genetic	27708008
MDS3_YEAST	MDS3	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
YPT7_YEAST	YPT7	genetic	27708008
GIS4_YEAST	GIS4	genetic	27708008
GAL80_YEAST	GAL80	genetic	27708008
MVP1_YEAST	MVP1	genetic	27708008
CSI1_YEAST	CSI1	genetic	27708008
YM04_YEAST	YMR114C	genetic	27708008
RU2A_YEAST	LEA1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-546; SER-697; SER-711;SER-992; SER-1286; SER-1307; SER-1309; SER-1355; SER-1356; SER-1486;SER-1611; SER-1612; SER-1642; SER-1664 AND SER-1668, AND MASSSPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-784; SER-785; SER-787;SER-989; SER-992; SER-1356; THR-1670 AND SER-1675, AND MASSSPECTROMETRY.
PubMed: 17563356

"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1307 AND SER-1356, ANDMASS SPECTROMETRY.
PubMed: 17330950

"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-877; SER-1292; SER-1642AND SER-1664, AND MASS SPECTROMETRY.
PubMed: 15665377