YM04_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YM04_YEAST
• UniProt AC: Q04471
• Protein Name: Putative peptidase YMR114C
• Gene Name: YMR114C
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 368
• Protein Sequence: MCGRFALAYDSGDLPQLLRDWNLPVNTPKDASSNSQHPHDEEDTKDQPTVSKDIFKASYNISPTNYSAVYRPDTKAIQFMRWGLVPFWTKDVSQFKTYRTFNARLENLQESKMWMRPCEKKRCAVLMSGYFEWKTVGKKKTPYFISRRDGRLMFVAGMYDYVEKDDLYTFTIITAQGPRELEWLHERMPCVLEPGTESWDAWMDVDKTTWSTEELVKLLKPDYDESKLQFYQVTDDVGKTTNTGERLIKPLLKEDSDMFSVKREKEEALLENDNEQGIDNRGVKGDKSLKGEDVFNQKKSLKRNSYDGLKKNEEQEETTLPEEGSIGDRVKREEANLSPKREGNREKRNIVNMLGNQKDSRGKKKIKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Other	------MCGRFALAY ------CCCCEEEEE	5.57	-
32	Phosphorylation	VNTPKDASSNSQHPH CCCCCCCCCCCCCCC	39.94	27017623
33	Phosphorylation	NTPKDASSNSQHPHD CCCCCCCCCCCCCCC	42.07	30377154
35	Phosphorylation	PKDASSNSQHPHDEE CCCCCCCCCCCCCCC	31.64	19779198
111	Phosphorylation	RLENLQESKMWMRPC HHHHHHHHCCCCCCC	18.17	28889911
141	Phosphorylation	KTVGKKKTPYFISRR EECCCCCCCEEEECC	31.91	30377154
256	Phosphorylation	KPLLKEDSDMFSVKR HHHCCCCCCCCCCCH	31.87	30377154
305	Phosphorylation	KKSLKRNSYDGLKKN HHHHCCCCCCCHHHC	28.74	23749301
306	Phosphorylation	KSLKRNSYDGLKKNE HHHCCCCCCCHHHCH	19.99	25752575
325	Phosphorylation	TTLPEEGSIGDRVKR CCCCCCCCHHHHHHH	27.03	30377154
338	Phosphorylation	KREEANLSPKREGNR HHHHHCCCCCCCCCH	28.34	17287358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YM04_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YM04_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YM04_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GPR1_YEAST	GPR1	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
CSN12_YEAST	YJR084W	genetic	27708008
SIW14_YEAST	SIW14	genetic	27708008
SNF5_YEAST	SNF5	genetic	27708008
THRC_YEAST	THR4	genetic	27708008
RL22A_YEAST	RPL22A	genetic	27708008
MED1_YEAST	MED1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, AND MASSSPECTROMETRY.
PubMed: 18407956

"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, AND MASSSPECTROMETRY.
PubMed: 17287358