| UniProt ID | SNF5_YEAST | |
|---|---|---|
| UniProt AC | P18480 | |
| Protein Name | SWI/SNF chromatin-remodeling complex subunit SNF5 | |
| Gene Name | SNF5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 905 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.. | |
| Protein Sequence | MNNQPQGTNSVPNSIGNIFSNIGTPSFNMAQIPQQLYQSLTPQQLQMIQQRHQQLLRSRLQQQQQQQQQTSPPPQTHQSPPPPPQQSQPIANQSATSTPPPPPAPHNLHPQIGQVPLAPAPINLPPQIAQLPLATQQQVLNKLRQQAIAKNNPQVVNAITVAQQQVQRQIEQQKGQQTAQTQLEQQRQLLVQQQQQQQLRNQIQRQQQQQFRHHVQIQQQQQKQQQQQQQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQGQIPQSQQVPQVRSMSGQPPTNVQPTIGQLPQLPKLNLPKYQTIQYDPPETKLPYPTYWSDKKADTDTLLYEQIIQRDKINKYSLIRETNGYDPFSIYGFSNKEYISRLWHTLKYYQDLKNTRMKSITSTSQKIPSASIWGNGYSGYGNGITNTTTRVIPQVEVGNRKHYLEDKLKVYKQAMNETSEQLVPIRLEFDQDRDRFFLRDTLLWNKNDKLIKIEDFVDDMLRDYRFEDATREQHIDTICQSIQEQIQEFQGNPYIELNQDRLGGDDLRIRIKLDIVVGQNQLIDQFEWDISNSDNCPEEFAESMCQELELPGEFVTAIAHSIREQVHMYHKSLALLGYNFDGSAIEDDDIRSRMLPTITLDDVYRPAAESKIFTPNLLQISAAELERLDKDKDRDTRRKRRQGRSNRRGMLALSGTSASNTSMNGVHNTVAAGNASSLPPGEILLPDIADIPRTFRTPVPSTLMPGGVDVGPSVESYELRNTTTYKSRPDRPKPVSPPCYIIDHIPGHSLLLSIKLPGKVNTKEEFAAAPNDTSSGTNAMLPSPESLKTKLNSNIRAGVTIPSIPNPIANHTVTNSPNPTLQPVIPGGAASKSVPTPSLPIAPPVAPHDSEATLLTNSNNGSSNNNTQNT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 174 | Ubiquitination | QRQIEQQKGQQTAQT HHHHHHHHCHHHHHH | 59.38 | 23749301 | |
| 284 | Phosphorylation | VPQVRSMSGQPPTNV CCCHHHCCCCCCCCC | 35.21 | 28152593 | |
| 308 | Acetylation | LPKLNLPKYQTIQYD CCCCCCCCCCCCCCC | 53.83 | 24489116 | |
| 350 | Acetylation | IQRDKINKYSLIRET HHHHCCCHHHCCCCC | 39.42 | 24489116 | |
| 394 | Phosphorylation | LKNTRMKSITSTSQK HHHCCCCCCCCCCCC | 23.04 | 23749301 | |
| 401 | Acetylation | SITSTSQKIPSASIW CCCCCCCCCCCCEEC | 57.25 | 24489116 | |
| 447 | Ubiquitination | EDKLKVYKQAMNETS HHHHHHHHHHHCCCC | 34.27 | 23749301 | |
| 481 | Acetylation | RDTLLWNKNDKLIKI HCEEEECCCCCEEEH | 55.74 | 24489116 | |
| 818 | Phosphorylation | GTNAMLPSPESLKTK CCCCCCCCHHHHHHH | 37.02 | 25521595 | |
| 821 | Phosphorylation | AMLPSPESLKTKLNS CCCCCHHHHHHHHCC | 38.25 | 25752575 | |
| 838 | Phosphorylation | RAGVTIPSIPNPIAN CCCCCCCCCCCCCCC | 46.99 | 21440633 | |
| 847 | Phosphorylation | PNPIANHTVTNSPNP CCCCCCCCCCCCCCC | 28.91 | 23749301 | |
| 849 | Phosphorylation | PIANHTVTNSPNPTL CCCCCCCCCCCCCCC | 31.00 | 21440633 | |
| 851 | Phosphorylation | ANHTVTNSPNPTLQP CCCCCCCCCCCCCCC | 19.38 | 21440633 | |
| 855 | Phosphorylation | VTNSPNPTLQPVIPG CCCCCCCCCCCCCCC | 44.67 | 24961812 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SNF5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SNF5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SNF5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818; SER-821 ANDSER-851, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818, AND MASSSPECTROMETRY. | |
