PTR2_YEAST - dbPTM
PTR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTR2_YEAST
UniProt AC P32901
Protein Name Peptide transporter PTR2
Gene Name PTR2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 601
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Uptake of small peptides..
Protein Sequence MLNHPSQGSDDAQDEKQGDFPVIEEEKTQAVTLKDSYVSDDVANSTERYNLSPSPEDEDFEGPTEEEMQTLRHVGGKIPMRCWLIAIVELSERFSYYGLSAPFQNYMEYGPNDSPKGVLSLNSQGATGLSYFFQFWCYVTPVFGGYVADTFWGKYNTICCGTAIYIAGIFILFITSIPSVGNRDSAIGGFIAAIILIGIATGMIKANLSVLIADQLPKRKPSIKVLKSGERVIVDSNITLQNVFMFFYFMINVGSLSLMATTELEYHKGFWAAYLLPFCFFWIAVVTLIFGKKQYIQRPIGDKVIAKSFKVCWILTKNKFDFNAAKPSVHPEKNYPWNDKFVDEIKRALAACKVFIFYPIYWTQYGTMISSFITQASMMELHGIPNDFLQAFDSIALIIFIPIFEKFVYPFIRRYTPLKPITKIFFGFMFGSFAMTWAAVLQSFVYKAGPWYNEPLGHNTPNHVHVCWQIPAYVLISFSEIFASITGLEYAYSKAPASMKSFIMSIFLLTNAFGSAIGCALSPVTVDPKFTWLFTGLAVACFISGCLFWLCFRKYNDTEEEMNAMDYEEEDEFDLNPISAPKANDIEILEPMESLRSTTKY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MLNHPSQGSDDAQ
--CCCCCCCCCCCCC		39.3524909858
9PhosphorylationLNHPSQGSDDAQDEK
CCCCCCCCCCCCCHH		25.3622369663
16UbiquitinationSDDAQDEKQGDFPVI
CCCCCCHHCCCCCEE		68.8023793018
27UbiquitinationFPVIEEEKTQAVTLK
CCEECCCCCCCEEEC		49.5723749301
32PhosphorylationEEKTQAVTLKDSYVS
CCCCCCEEECCCCCC		30.9819779198
34UbiquitinationKTQAVTLKDSYVSDD
CCCCEEECCCCCCHH		34.9523749301
36PhosphorylationQAVTLKDSYVSDDVA
CCEEECCCCCCHHCC		26.3322890988
37PhosphorylationAVTLKDSYVSDDVAN
CEEECCCCCCHHCCC		17.6922369663
39PhosphorylationTLKDSYVSDDVANST
EECCCCCCHHCCCCC		21.6222369663
45PhosphorylationVSDDVANSTERYNLS
CCHHCCCCCCCCCCC		23.1622369663
46PhosphorylationSDDVANSTERYNLSP
CHHCCCCCCCCCCCC		25.0422369663
49PhosphorylationVANSTERYNLSPSPE
CCCCCCCCCCCCCCC		17.7722890988
52PhosphorylationSTERYNLSPSPEDED
CCCCCCCCCCCCCCC		21.5019823750
54PhosphorylationERYNLSPSPEDEDFE
CCCCCCCCCCCCCCC		37.2322890988
64PhosphorylationDEDFEGPTEEEMQTL
CCCCCCCCHHHHHHH		67.8719823750
70PhosphorylationPTEEEMQTLRHVGGK
CCHHHHHHHHHCCCC		25.1719823750
319AcetylationCWILTKNKFDFNAAK
EEEEECCCCCCCCCC		48.1124489116
594PhosphorylationEILEPMESLRSTTKY
HHCCCHHHHHCCCCC		23.8822369663
597PhosphorylationEPMESLRSTTKY---
CCHHHHHCCCCC---		45.8025521595
598PhosphorylationPMESLRSTTKY----
CHHHHHCCCCC----		22.3722369663
599PhosphorylationMESLRSTTKY-----
HHHHHCCCCC-----		29.5922369663
600UbiquitinationESLRSTTKY------
HHHHCCCCC------		49.3923749301
601PhosphorylationSLRSTTKY-------
HHHCCCCC-------		22.9922890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTR2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DAL5_YEASTDAL5genetic
16429164
SEC66_YEASTSEC66genetic
19325107
ADK_YEASTADO1genetic
21623372
SERB_YEASTSER2genetic
21623372
SUR1_YEASTSUR1genetic
21623372
TREA_YEASTNTH1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
ARO8_YEASTARO8genetic
21623372
CBS_YEASTCYS4genetic
21623372
CYS3_YEASTCYS3genetic
21623372
THI22_YEASTTHI22genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
DCAM_YEASTSPE2genetic
21623372
AMDY_YEASTAMD2genetic
21623372
COX5A_YEASTCOX5Agenetic
27708008
MRC1_YEASTMRC1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
RPA14_YEASTRPA14genetic
27708008
FDC1_YEASTFDC1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
CHAC_YEASTGCG1genetic
27708008
ODPA_YEASTPDA1genetic
27708008
PEX2_YEASTPEX2genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
ADY4_YEASTADY4genetic
27708008
ARV1_YEASTARV1genetic
27708008
EFM7_YEASTNNT1genetic
27708008
VBA1_YEASTVBA1genetic
27708008
PHO80_YEASTPHO80genetic
27708008
IZH2_YEASTIZH2genetic
27708008
MDM12_YEASTMDM12genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
SYT1_YEASTSYT1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTR2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-37; SER-39; SER-45 ANDSER-594, AND MASS SPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-45; SER-594 ANDSER-597, AND MASS SPECTROMETRY.

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