FDC1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FDC1_YEAST
• UniProt AC: Q03034
• Protein Name: Ferulic acid decarboxylase 1 {ECO:0000255|HAMAP-Rule:MF_03196, ECO:0000303|PubMed:20471595}
• Gene Name: FDC1 {ECO:0000255|HAMAP-Rule:MF_03196, ECO:0000303|PubMed:20471595}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 503
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites. [PubMed: 20471595]
• Protein Sequence: MRKLNPALEFRDFIQVLKDEDDLIEITEEIDPNLEVGAIMRKAYESHLPAPLFKNLKGASKDLFSILGCPAGLRSKEKGDHGRIAHHLGLDPKTTIKEIIDYLLECKEKEPLPPITVPVSSAPCKTHILSEEKIHLQSLPTPYLHVSDGGKYLQTYGMWILQTPDKKWTNWSIARGMVVDDKHITGLVIKPQHIRQIADSWAAIGKANEIPFALCFGVPPAAILVSSMPIPEGVSESDYVGAILGESVPVVKCETNDLMVPATSEMVFEGTLSLTDTHLEGPFGEMHGYVFKSQGHPCPLYTVKAMSYRDNAILPVSNPGLCTDETHTLIGSLVATEAKELAIESGLPILDAFMPYEAQALWLILKVDLKGLQALKTTPEEFCKKVGDIYFRTKVGFIVHEIILVADDIDIFNFKEVIWAYVTRHTPVADQMAFDDVTSFPLAPFVSQSSRSKTMKGGKCVTNCIFRQQYERSFDYITCNFEKGYPKGLVDKVNENWKRYGYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Acetylation	HLPAPLFKNLKGASK CCCHHHHCCCCCCCH	69.88	22865919
116	Phosphorylation	KEPLPPITVPVSSAP CCCCCCCEEECCCCC	25.24	27017623
120	Phosphorylation	PPITVPVSSAPCKTH CCCEEECCCCCCCCC	18.08	28889911
121	Phosphorylation	PITVPVSSAPCKTHI CCEEECCCCCCCCCC	36.14	27017623
126	Phosphorylation	VSSAPCKTHILSEEK CCCCCCCCCCCCCCC	22.36	19779198
130	Phosphorylation	PCKTHILSEEKIHLQ CCCCCCCCCCCCCCC	43.01	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FDC1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FDC1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FDC1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BUD31_YEAST	BUD31	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
PEX3_YEAST	PEX3	genetic	27708008
PEX13_YEAST	PEX13	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.